Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia

Autor: Crabbé, Melissa, Van der Perren, Anke, Weerasekera, Akila, Himmelreich, Uwe, Baekelandt, Veerle, Van Laere, Koen, Casteels, Cindy

Publikováno v: In Neurobiology of Aging January 2018 61:82-92

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors

Autor: Van der Perren, Anke, Toelen, Jaan, Casteels, Cindy, Macchi, Francesca, Van Rompuy, Anne-Sophie, Sarre, Sophie, Casadei, Nicolas, Nuber, Silke, Himmelreich, Uwe, Osorio Garcia, Maria Isabel, Michotte, Yvette, D'Hooge, Rudi, Bormans, Guy, Van Laere, Koen, Gijsbers, Rik, Van den Haute, Chris, Debyser, Zeger, Baekelandt, Veerle

Publikováno v: In Neurobiology of Aging March 2015 36(3):1543-1558

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Identification of the allosteric P2X receptor antagonist [C]SMW139 as a PET tracer of microglial activation

Autor: Janssen, Bieneke, Vugts, Danielle J, Wilkinson, Shane M, Ory, Dieter, Chalon, Sylvie, Hoozemans, Jeroen J M, Schuit, Robert C, Beaino, Wissam, Kooijman, Esther J M, van den Hoek, Johan, Chishty, Mansoor, Doméné, Aurélie, Van der Perren, Anke, Villa, Alessandro, Maggi, Adriana, Molenaar, Ger T, Funke, Uta, Shevchenko, Rostislav V, Baekelandt, Veerle, Bormans, Guy, Lammertsma, Adriaan A, Kassiou, Michael, Windhorst, Albert D

Publikováno v: Scientific Reports, 8(1). Nature Publishing Group
Janssen, B, Vugts, D J, Wilkinson, S M, Ory, D, Chalon, S, Hoozemans, J J M, Schuit, R C, Beaino, W, Kooijman, E J M, van den Hoek, J, Chishty, M, Doméné, A, Van der Perren, A, Villa, A, Maggi, A, Molenaar, G T, Funke, U, Shevchenko, R V, Baekelandt, V, Bormans, G, Lammertsma, A A, Kassiou, M & Windhorst, A D 2018, ' Identification of the allosteric P2X receptor antagonist [C]SMW139 as a PET tracer of microglial activation ', Scientific Reports, vol. 8, no. 1, pp. 6580 . https://doi.org/10.1038/s41598-018-24814-0

The P2X7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X7 receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ab56863bea8216f62f0bf8497ba3931e
https://research.vumc.nl/en/publications/f9bf094c-fe1b-4355-a75b-5dd0a7abe98e