Aberrant innate immune profile associated with COVID-19 mortality in Pretoria, South Africa.

Autor: van der Mescht MA; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., de Beer Z; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; Tshwane District Hospital, Pretoria, South Africa., Steel HC; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Anderson R; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Masenge A; Department of Statistics, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa., Moore PL; MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Bastard P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France; Paris Cité University, Imagine Institute, Paris, France; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistante Publique-Hôpitaux de Paris (AP-HP), Paris, France., Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France; Paris Cité University, Imagine Institute, Paris, France; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistante Publique-Hôpitaux de Paris (AP-HP), Paris, France; Howard Hughes Medical Institute, New York, NY, USA., Abdullah F; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa; Office of AIDS and TB Research, South African Medical Research Council, Pretoria, South Africa; Department of Public Health Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Ueckermann V; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Rossouw TM; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. Electronic address: theresa.rossouw@up.ac.za.

Publikováno v: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2024 Sep; Vol. 266, pp. 110323. Date of Electronic Publication: 2024 Jul 17.

Comparison of platelet-and endothelial-associated biomarkers of disease activity in people hospitalized with Covid-19 with and without HIV co-infection.

Autor: van der Mescht MA; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Steel HC; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., de Beer Z; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Family Medicine, Tshwane District Hospital, Pretoria, South Africa., Abdullah F; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa.; Office of AIDS and TB Research, South African Medical Research Council, Pretoria, South Africa., Ueckermann V; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Anderson R; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Rossouw TM; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Family Medicine, Tshwane District Hospital, Pretoria, South Africa.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Aug 14; Vol. 14, pp. 1235914. Date of Electronic Publication: 2023 Aug 14 (Print Publication: 2023).

Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant.

Autor: Richardson SI; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Kgagudi P; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Manamela NP; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Kaldine H; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Venter EM; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Pillay T; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Lambson BE; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., van der Mescht MA; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Hermanus T; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Balla SR; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., de Beer Z; Tshwane District Hospital, Pretoria, South Africa., de Villiers TR; Tshwane District Hospital, Pretoria, South Africa., Bodenstein A; Tshwane District Hospital, Pretoria, South Africa., van den Berg G; Tshwane District Hospital, Pretoria, South Africa., du Pisanie M; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Burgers WA; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Division of Medical Virology, Department of Pathology; University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa., Ntusi NAB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Abdullah F; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Ueckermann V; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Rossouw TM; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Boswell MT; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Moore PL; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa; South African Medical Research Council Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa. Electronic address: pennym@nicd.ac.za.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Jan 17; Vol. 4 (1), pp. 100910. Date of Electronic Publication: 2022 Dec 22.

Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants.

Autor: Moyo-Gwete T; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Madzivhandila M; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mkhize NN; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Kgagudi P; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Ayres F; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Lambson BE; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Manamela NP; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Richardson SI; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Makhado Z; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., van der Mescht MA; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., de Beer Z; Tshwane District Hospital, Pretoria, South Africa., de Villiers TR; Tshwane District Hospital, Pretoria, South Africa., Burgers WA; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Towngrid.7836.a, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Towngrid.7836.a, Cape Town, South Africa., Ntusi NAB; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Towngrid.7836.a, Cape Town, South Africa.; Division of Cardiology, Department of Medicine, University of Cape Towngrid.7836.a and Groote Schuur Hospital, Cape Town, South Africa.; Cape Heart Institute, Faculty of Health Sciences, University of Cape Towngrid.7836.a, Cape Town, South Africa., Rossouw T; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Ueckermann V; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Boswell MT; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Moore PL; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Towngrid.7836.a, Cape Town, South Africa.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.

Publikováno v: Journal of virology [J Virol] 2022 Aug 10; Vol. 96 (15), pp. e0055822. Date of Electronic Publication: 2022 Jul 13.

Author Correction: T cell responses to SARS-CoV-2 spike cross-recognize Omicron.

Autor: Keeton R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Tincho MB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Ngomti A; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Baguma R; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Benede N; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Suzuki A; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa., Khan K; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Cele S; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Bernstein M; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Karim F; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Madzorera SV; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Moyo-Gwete T; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Mennen M; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Skelem S; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Adriaanse M; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Mutithu D; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Aremu O; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Stek C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., du Bruyn E; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa., Van Der Mescht MA; Department of Immunology, University of Pretoria, Pretoria, South Africa., de Beer Z; Tshwane District Hospital, Tshwane, South Africa., de Villiers TR; Tshwane District Hospital, Tshwane, South Africa., Bodenstein A; Tshwane District Hospital, Tshwane, South Africa., van den Berg G; Tshwane District Hospital, Tshwane, South Africa., Mendes A; Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa., Strydom A; Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa., Venter M; Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria, South Africa., Giandhari J; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Naidoo Y; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Pillay S; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa., Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA., Wilkinson RJ; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Infectious Diseases, Imperial College London, London, UK.; The Francis Crick Institute, London, UK., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban, South Africa.; Centre for Epidemic Response and Innovation, Stellenbosch University, Stellenbosch, South Africa., Bekker LG; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa.; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Gray G; South African Medical Research Council, Cape Town, South Africa., Ueckermann V; Department of Internal Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa., Rossouw T; Department of Immunology, University of Pretoria, Pretoria, South Africa., Boswell MT; Department of Internal Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa., Bhiman JN; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Moore PL; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Sigal A; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany., Ntusi NAB; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa.; Department of Medicine, University of Cape Town and Groote Schuur Hospital; Observatory, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, South Africa.; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town; Observatory, Cape Town, South Africa., Burgers WA; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa. wendy.burgers@uct.ac.za.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa. wendy.burgers@uct.ac.za.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, South Africa. wendy.burgers@uct.ac.za., Riou C; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa. cr.riou@uct.ac.za.; Division of Medical Virology, Department of Pathology, University of Cape Town; Observatory, Cape Town, South Africa. cr.riou@uct.ac.za.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, Cape Town, South Africa. cr.riou@uct.ac.za.

Publikováno v: Nature [Nature] 2022 Apr; Vol. 604 (7907), pp. E25.