Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

Autor: Van Der Klaauw, AA, Croizier, S, De Oliveira, E, Stadler, LKJ, Park, S, Kong, Y, Banton, MC, Tandon, P, Hendricks, AE, Keogh, JM, Riley, SE, Papadia, S, Henning, E, Bounds, R, Bochukova, EG, Mistry, V, O'Rahilly, S, Simerly, RB, Interval, Consortium, Uk10K, Minchin, JEN, Barroso, I, Jones, EY, Bouret, SG, Farooqi, IS

Publikováno v: Cell
Cell, 2019, 176 (4), pp.729-742.e18. ⟨10.1016/j.cell.2018.12.009⟩
Van Der Klaauw, A A, Croizier, S, Mendes De Oliveira, E, Stadler, L K J, Park, S, Kong, Y, Banton, M C, Tandon, P, Hendricks, A E, Keogh, J M, Riley, S E, Papadia, S, Henning, E, Bounds, R, Bochukova, E G, Mistry, V, O’rahilly, S, Simerly, R B, Minchin, J E N, Barroso, I & Jones, E Y & Bouret, S G & Farooqi, I S 2019, ' Human semaphorin 3 variants link melanocortin circuit development and energy balance ', Cell, vol. 176, no. 4, pp. 729-742 . https://doi.org/10.1016/j.cell.2018.12.009
Cell, Elsevier, 2019, 176 (4), pp.729-742.e18. ⟨10.1016/j.cell.2018.12.009⟩
Cell, vol. 176, no. 4, pp. 729-742.e18

Summary Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants in SEMA3A-G a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eb92bc3fd4ba670283a473e22557d3
https://hal.science/hal-02375383/file/S0092867418316234.pdf

KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation

Autor: Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ, UK10K consortium, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS, Pearce LR, Atanassova N, Banton MC, Bottomley B, van der Klaauw AA, Revelli JP, Hendricks A, Keogh JM, Henning E, Doree D, Jeter-Jones S, Garg S, Bochukova EG, Bounds R, Ashford S, Gayton E, Hindmarsh PC, Shield JP, Crowne E, Barford D, Wareham NJ, UK10K consortium, O'Rahilly S, Murphy MP, Powell DR, Barroso I, Farooqi IS

Publikováno v: Cell.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::998f8007468bd6170371df0405ca8f25

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Persistence of immune responses after heterologous and homologous third COVID-19 vaccine dose schedules in the UK: eight-month analyses of the COV-BOOST trial.

Autor: Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. Electronic address: xinxue.liu@paediatrics.ox.ac.uk., Munro APS; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Wright A; Imperial Clinical Trials Unit, Imperial College London, London, UK., Feng S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Janani L; Imperial Clinical Trials Unit, Imperial College London, London, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Babbage G; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Baker J; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Baxter D; Stockport NHS Foundation Trust, Stockport, UK., Bawa T; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK., Bula M; NIHR Liverpool Clinical Research Facility, Liverpool, UK., Cathie K; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Chatterjee K; NIHR Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Dodd K; NIHR Liverpool Clinical Research Facility, Liverpool, UK., Enever Y; PHARMExcel, Welwyn Garden City, Hertfordshire, UK., Fox L; Portsmouth Hospitals University NHS Trust, Portsmouth, UK., Qureshi E; NIHR/Wellcome Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Goodman AL; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK; MRC Clinical Trials Unit, University College London, London, UK., Green CA; NIHR/Wellcome Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Haughney J; Queen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, UK., Hicks A; Portsmouth Hospitals University NHS Trust, Portsmouth, UK., Jones CE; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Kanji N; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., van der Klaauw AA; Wellcome-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK., Libri V; NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK., Llewelyn MJ; University Hospitals Sussex NHS Foundation Trust, Brighton, UK., Mansfield R; Dorset Research Hub, Bournemouth, UK., Maallah M; Department of Infectious Diseases and Tropical Medicine, London Northwest University Healthcare, London, UK., McGregor AC; Department of Infectious Diseases and Tropical Medicine, London Northwest University Healthcare, London, UK., Minassian AM; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Moore P; The Adam Practice, Poole, UK., Mughal M; Stockport NHS Foundation Trust, Stockport, UK., Mujadidi YF; NIHR Oxford Biomedical Research Centre, Oxford, UK., Belhadef HT; NIHR Oxford Biomedical Research Centre, Oxford, UK., Holliday K; NIHR Leeds Clinical Research Facility, Leeds Teaching Hospitals Trust and University of Leeds, Leeds, UK., Osanlou O; Public Health Wales, Betsi Cadwaladr University Health Board, Bangor University, Bangor, UK., Osanlou R; University of Liverpool, Liverpool, UK., Owens DR; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Pacurar M; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Palfreeman A; University Hospitals of Leicester NHS Trust, University of Leicester, Leicester, UK., Pan D; University Hospitals of Leicester NHS Trust, University of Leicester, Leicester, UK; Department of Respiratory Sciences, University of Leicester, Leicester, UK., Rampling T; NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK., Regan K; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Saich S; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Saralaya D; Bradford Institute for Health Research and Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK., Sharma S; University Hospitals Sussex NHS Foundation Trust, Brighton, UK., Sheridan R; Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK., Stokes M; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Thomson EC; Queen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, UK; MRC University of Glasgow Centre for Virus Research, Glasgow, UK., Todd S; Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK., Twelves C; NIHR Leeds Clinical Research Facility, Leeds Teaching Hospitals Trust and University of Leeds, Leeds, UK., Read RC; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Charlton S; UK Health Security Agency, Porton Down, UK., Hallis B; UK Health Security Agency, Porton Down, UK., Ramsay M; UK Health Security Agency, Colindale, London, UK., Andrews N; UK Health Security Agency, Colindale, London, UK., Lambe T; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Nguyen-Van-Tam JS; Lifespan and Population Health Unit, University of Nottingham School of Medicine, UK., Cornelius V; Imperial Clinical Trials Unit, Imperial College London, London, UK., Snape MD; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: s.faust@soton.ac.uk.

Publikováno v: The Journal of infection [J Infect] 2023 Jul; Vol. 87 (1), pp. 18-26. Date of Electronic Publication: 2023 Apr 20.