Zobrazeno 1 - 10
of 8 218
pro vyhledávání: '"Van Den Heuvel, P A."'
Autor:
Demi T C de Winter, Sebastian J C M M Neggers, Marry M van den Heuvel-Eibrink, Jenneke E van Atteveld
Publikováno v:
Endocrine Connections, Vol 13, Iss 12, Pp 1-13 (2024)
Childhood cancer survivors are at increased risk of developing (long-term) skeletal adverse effects, such as osteonecrosis, impaired bone mineral density, and fractures. This paper provides an overview of the current understanding of bone health in t
Externí odkaz:
https://doaj.org/article/79d34d256abc46b096131cfe7b2fc232
Autor:
Max A. Laansma, Yuji Zhao, Eva M. van Heese, Joanna K. Bright, Conor Owens-Walton, Sarah Al-Bachari, Tim J. Anderson, Francesca Assogna, Tim D. van Balkom, Henk W. Berendse, Fernando Cendes, John C. Dalrymple-Alford, Ines Debove, Michiel F. Dirkx, Jason Druzgal, Hedley C. A. Emsley, Jean-Paul Fouche, Gaëtan Garraux, Rachel P. Guimarães, Rick C. Helmich, Michele Hu, Odile A. van den Heuvel, Dmitry Isaev, Ho-Bin Kim, Johannes C. Klein, Christine Lochner, Corey T. McMillan, Tracy R. Melzer, Benjamin Newman, Laura M. Parkes, Clelia Pellicano, Fabrizio Piras, Toni L. Pitcher, Kathleen L. Poston, Mario Rango, Leticia F. Ribeiro, Cristiane S. Rocha, Christian Rummel, Lucas S. R. Santos, Reinhold Schmidt, Petra Schwingenschuh, Letizia Squarcina, Dan J. Stein, Daniela Vecchio, Chris Vriend, Jiunjie Wang, Daniel Weintraub, Roland Wiest, Clarissa L. Yasuda, Neda Jahanshad, Paul M. Thompson, Ysbrand D. van der Werf, Boris A. Gutman
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Alterations in subcortical brain regions are linked to motor and non-motor symptoms in Parkinson’s disease (PD). However, associations between clinical expression and regional morphological abnormalities of the basal ganglia, thalamus, amy
Externí odkaz:
https://doaj.org/article/0ad01d15502c49b4bbf825957015ee01
Autor:
Thomas A. Kluiver, Yuyan Lu, Stephanie A. Schubert, Lianne J. Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L. Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W. de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C. van den Heuvel, Vincent E. de Meijer, Ruben H. de Kleine, Jan J. Molenaar, Thanasis Margaritis, Hendrik G. Stunnenberg, Ronald R. de Krijger, József Zsiros, Hans Clevers, Weng Chuan Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we per
Externí odkaz:
https://doaj.org/article/e9c310a9ac5d476ba9c8f3c8d25d32c8
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 1289-1293 (2024)
Introduction: Adagrasib is an upcoming anticancer treatment for KRAS G12C-mutated non-small-cell lung carcinoma, colorectal cancer and potentially other solid tumors harboring this mutation. It is generally well-tolerated and reports of neurological
Externí odkaz:
https://doaj.org/article/cdab845bb1754d2a9f0e38fac4801d65
Autor:
Nicky R. Faber, Xuejiao Xu, Jingheng Chen, Shibo Hou, Jie Du, Bart A. Pannebakker, Bas J. Zwaan, Joost van den Heuvel, Jackson Champer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Gene drive technology has the potential to address major biological challenges. Well-studied homing suppression drives have been shown to be highly efficient in Anopheles mosquitoes, but for other organisms, lower rates of drive conversion p
Externí odkaz:
https://doaj.org/article/2dad480613e447f5bbb25796ff646056
Autor:
I M A A van Roessel, J E Gorter, B Bakker, M M van den Heuvel-Eibrink, M H Lequin, J van der Lugt, L Meijer, A Y N Schouten-van Meeteren, H M van Santen
Publikováno v:
Endocrine Connections, Vol 13, Iss 10, Pp 1-9 (2024)
Objective: Children with a supratentorial midline low-grade glioma (LGG) may be at risk for impaired bone health due to hypothalamic-pituitary dysfunction, obesity, exposure to multiple treatment modalities, and/or decreased mobility. The presence of
Externí odkaz:
https://doaj.org/article/7ed742e2aa934db7a99ef62ed41a9caf
Autor:
Puck J. A. M. Mulders, Edwin R. van den Heuvel, M. J. G. (René) van de Molengraft, W. P. M. H. (Maurice) Heemels, Pytrik Reidsma
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-9 (2024)
Abstract Extreme weather events cause damage to crops. Quantifying their impact on crop yields in farmers’ fields however remains difficult, as empirical data generally lacks detail, preventing to unravel causal effects from soil and management pra
Externí odkaz:
https://doaj.org/article/d8ff12eae02c4ef798d3c9edfdfddc4a
Autor:
Aimée S. R. Westerveld, Pien Roesthuis, Helena J. H. van der Pal, Dorine Bresters, Marc Bierings, Jacqueline Loonen, Andrica C. H. de Vries, Marloes Louwerens, Maria M. W. Koopman, Marry M. van den Heuvel-Eibrink, Margriet van der Heiden-van der Loo, Peter Hoogerbrugge, Geert O. Janssens, Ronald R. de Krijger, Cecile M. Ronckers, Rob Pieters, Leontien C. M. Kremer, Jop C. Teepen
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Acute lymphoblastic leukemia (ALL) survivors are at risk for developing subsequent neoplasms, but there is limited information on long-term risks and risk factors for both subsequent malignant neoplasms (SMNs) and subsequent non-malignant ne
Externí odkaz:
https://doaj.org/article/dd1578a6e4ab4a39aa7be9fb7ad260a1
Autor:
Renata Vieira de Sá, Emma Sudria-Lopez, Marta Cañizares Luna, Oliver Harschnitz, Dianne M. A. van den Heuvel, Sandra Kling, Danielle Vonk, Henk-Jan Westeneng, Henk Karst, Lauri Bloemenkamp, Suzy Varderidou-Minasian, Domino K. Schlegel, Mayte Mars, Mark H. Broekhoven, Nicky C. H. van Kronenburg, Youri Adolfs, Vamshidhar R. Vangoor, Rianne de Jongh, Tijana Ljubikj, Lianne Peeters, Sabine Seeler, Enric Mocholi, Onur Basak, David Gordon, Fabrizio Giuliani, Tessa Verhoeff, Giel Korsten, Teresa Calafat Pla, Morten T. Venø, Jørgen Kjems, Kevin Talbot, Michael A. van Es, Jan H. Veldink, Leonard H. van den Berg, Pavol Zelina, R. Jeroen Pasterkamp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Intermediate-length repeat expansions in ATAXIN-2 (ATXN2) are the strongest genetic risk factor for amyotrophic lateral sclerosis (ALS). At the molecular level, ATXN2 intermediate expansions enhance TDP-43 toxicity and pathology. However, wh
Externí odkaz:
https://doaj.org/article/f542924285bc411ab2ef82b8bba3d188
Autor:
Manon Meerman, Marit Buijser, Lettie van den Berg, Anne-Marthe van den Heuvel, Gerard Hoohenkerk, Vincent van Driel, Luuk Munsterman, Roel de Vroege, Michael Bailey, Rinaldo Bellomo, Jeroen Ludikhuize
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Postoperative atrial fibrillation (POAF) is a common and potentially serious complication post cardiac surgery. Hypomagnesaemia is common after cardiac surgery and recent evidence indicates that supplementation of magnesium may pr
Externí odkaz:
https://doaj.org/article/720e76059ea14884ad608ebd2912ca28