A novel method for recombinant mammalian-expressed S-HBsAg virus-like particle production for assembly status analysis and improved anti-HBs serology.

Autor: Lehky M; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany., Moonian T; Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Michel T; Department of Multiplex Immunoassays, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany., Junker D; Department of Multiplex Immunoassays, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany., Müsken M; Central Facility for Microscopy, Helmholtz Centre for Infection Research, Braunschweig, Germany., Strömpl J; Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Nübling P; Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Neumann F; Laboratory Dr. Krause and Colleagues MVZ GmbH, Kiel, Germany., Krumbholz A; Laboratory Dr. Krause and Colleagues MVZ GmbH, Kiel, Germany.; Institute for Infection Medicine, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany., Krause G; Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; German Centre for Infection Research (DZIF), Braunschweig-Hannover, Germany.; TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture of Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany., Schneiderhan-Marra N; Department of Multiplex Immunoassays, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany., van den Heuvel J; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany., Strengert M; Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture of Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.; Department of Virus-based Technologies, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Biberach an der Riß, Germany.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2025 Jan; Vol. 34 (1), pp. e5251.

Patient-initiated video consultations: A qualitative study on reasons for patient-booking in Danish general practice.

Autor: Van den Heuvel J; Center for General Practice, Aalborg University Department of Clinical Medicine, Aalborg, Region Nordjylland, Denmark., Assing Hvidt E; Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark., Dahl-Larsen R; Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark., Thomsen JL; Center for General Practice, Aalborg University Department of Clinical Medicine, Aalborg, Region Nordjylland, Denmark., Hoffmann Merrild C; Center for General Practice, Aalborg University Department of Clinical Medicine, Aalborg, Region Nordjylland, Denmark.

Publikováno v: Digital health [Digit Health] 2024 Oct 08; Vol. 10, pp. 20552076241288637. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024).

The cytomegalovirus M35 protein directly binds to the interferon-β enhancer and modulates transcription of (Ifnb1) and other IRF3-driven genes

Autor: Schwanke, H., Gonçalves Magalhães, V., Schmelz, S., Wyler, E., Hennig, T., Günther, T., Grundhoff, A., Dölken, L., Landthaler, M., van Ham, M., Jänsch, L., Büssow, K., van den Heuvel, J., Blankenfeldt, W., Friedel, C.C., Erhard, F., Brinkmann, M.M.

Induction of type I interferon (IFN) gene expression is among the first lines of cellular defense a virus encounters during primary infection. We previously identified the tegument protein M35 of murine cytomegalovirus (MCMV) as an essential antagoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::b91c8dfc14c0b0d3112640cc037ffb25
http://edoc.mdc-berlin.de/23521/1/23521oa.pdf

Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".

Autor: Sun S, Fushimi M, Rossetti T, Kaur N, Ferreira J, Miller M, Quast J, van den Heuvel J, Steegborn C, Levin LR, Buck J, Myers RW, Kargman S, Liverton N, Meinke PT, Huggins DJ

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2024 Feb 12; Vol. 64 (3), pp. 1106. Date of Electronic Publication: 2024 Jan 23.

A life-history allele of large effect shortens developmental time in a wild insect population.

Autor: Cheng S; Institute of Biology, Leiden University, Leiden, the Netherlands., Jacobs CGC; Institute of Biology, Leiden University, Leiden, the Netherlands., Mogollón Pérez EA; Institute of Biology, Leiden University, Leiden, the Netherlands.; Faculty of Biology, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany., Chen D; Mathematical Institute, Leiden University, Leiden, the Netherlands., van de Sanden JT; Institute of Biology, Leiden University, Leiden, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands., Bretscher KM; Institute of Biology, Leiden University, Leiden, the Netherlands., Verweij F; Institute of Biology, Leiden University, Leiden, the Netherlands., Bosman JS; Institute of Biology, Leiden University, Leiden, the Netherlands., Hackmann A; Institute of Biology, Leiden University, Leiden, the Netherlands., Merks RMH; Institute of Biology, Leiden University, Leiden, the Netherlands.; Mathematical Institute, Leiden University, Leiden, the Netherlands., van den Heuvel J; Laboratory of Genetics, Wageningen University and Research, Wageningen, the Netherlands., van der Zee M; Institute of Biology, Leiden University, Leiden, the Netherlands. m.van.der.zee@biology.leidenuniv.nl.

Publikováno v: Nature ecology & evolution [Nat Ecol Evol] 2024 Jan; Vol. 8 (1), pp. 70-82. Date of Electronic Publication: 2023 Nov 13.