Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation

Autor: Hellyer, Thomas P, McAuley, Daniel F, Walsh, Timothy S, Anderson, Niall, Conway Morris, Andrew, Singh, Suveer, Dark, Paul, Roy, Alistair I, Perkins, Gavin D, McMullan, Ronan, Emerson, Lydia M, Blackwood, Bronagh, Wright, Stephen E, Kefala, Kallirroi, O'Kane, Cecilia M, Baudouin, Simon V, Paterson, Ross L, Rostron, Anthony J, Agus, Ashley, Bannard-Smith, Jonathan, Robin, Nicole M, Welters, Ingeborg D, Bassford, Christopher, Yates, Bryan, Spencer, Craig, Laha, Shondipon K, Hulme, Jonathan, Bonner, Stephen, Linnett, Vanessa, Sonksen, Julian, Van Den Broeck, Tina, Boschman, Gert, Keenan, DW James, Scott, Jonathan, Allen, A Joy, Phair, Glenn, Parker, Jennie, Bowett, Susan A, Simpson, A John ^*

Publikováno v: In The Lancet Respiratory Medicine February 2020 8(2):182-191

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Randomised controlled trial and process evaluation of biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia

Autor: Hellyer, Thomas, McAuley, Daniel F, Walsh, Timothy S, Anderson, Niall, Conway Morris, Andrew, Singh, Suveer, Dark, Paul, Roy, Alistair I, Perkins, Gavin D, McMullan, Ronan, Emerson, Lydia M, Blackwood, Bronagh, Wright, Stephen E, Kefala, Kallirroi, O’Kane, Cecilia M, Baudouin, Simon V, Paterson, Ross L, Rostron, Anthony J, Agus, Ashley, Bannard-Smith, Jonathan, Robin, Nicole M, Welters, Ingeborg D, Bassford, Christopher, Yates, Bryan, Spencer, Craig, Laha, Shondipon K, Hulme, Jonathan, Bonner, Stephen, Linnett, Vanessa, Sonksen, Julian, Van Den Broeck, Tina, Boschman, Gert, Keenan, James, Scott, Jonathan, Allen, A Joy, Phair, Glenn, Parker, Jennie, Bowett, Susan A, Simpson, A John

BACKGROUND. Ventilator-associated pneumonia (VAP) is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1 and IL-8 in bronchoalveolar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139a6861401f19bed267e73375549d57

Effectiveness of a biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use: protocol for a randomised controlled trial (VAPrapid-2):Study protocol for a randomised controlled trial

Autor: Hellyer, Thomas P., Anderson, Niall H., Parker, Jennie, Dark, Paul, van den Broeck, Tina, Singh, Suveer, McMullan, Ronan, Agus, Ashley, Emerson, Lydia M., Blackwood, Bronagh, Gossain, Savita, Walsh, Tim, Perkins, Gavin, Conway Morris, Andre, McAuley, Daniel F., Simpson, A. John

Publikováno v: Hellyer, T P, Anderson, N H, Parker, J, Dark, P, van den Broeck, T, Singh, S, McMullan, R, Agus, A, Emerson, L M, Blackwood, B, Gossain, S, Walsh, T, Perkins, G, Conway Morris, A, McAuley, D F & Simpson, A J 2016, ' Effectiveness of a biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use: protocol for a randomised controlled trial (VAPrapid-2) : Study protocol for a randomised controlled trial ', Trials, vol. 17, no. 1, 318 . https://doi.org/10.1186/s13063-016-1442-x

Background Ventilator-acquired pneumonia (VAP) is a common reason for antimicrobial therapy in the intensive care unit (ICU). Biomarker-based diagnostics could improve antimicrobial stewardship through rapid exclusion of VAP. Bronchoalveloar lavage (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2607::ead5480b463606eca0e734a65aaf3ca7
https://pure.qub.ac.uk/en/publications/effectiveness-of-a-biomarkerbased-exclusion-of-ventilatoracquired-pneumonia-to-reduce-antibiotic-use-protocol-for-a-randomised-controlled-trial-vaprapid2(494f6710-a00d-4549-811c-549a675f2c9d).html

Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2): study protocol for a randomised controlled trial.

Autor: Hellyer, Thomas P., Anderson, Niall H., Parker, Jennie, Dark, Paul, Van Den Broeck, Tina, Singh, Suveer, McMullan, Ronan, Agus, Ashley M., Emerson, Lydia M., Blackwood, Bronagh, Gossain, Savita, Walsh, Tim S., Perkins, Gavin D., Morris, Andrew Conway, McAuley, Daniel F., Simpson, A. John, Conway Morris, Andrew

Publikováno v: Trials; 7/16/2016, Vol. 17, p318-325, 8p, 1 Diagram, 1 Chart, 1 Graph