Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Van Den Boomen, Dick JH"'
Autor:
Stefanovic-Barrett, Sandra, Dickson, Anna S, Burr, Stephen P, Williamson, James C, Lobb, Ian T, Van Den Boomen, Dick Jh, Lehner, Paul J, Nathan, James A
Misfolded or damaged proteins are typically targeted for destruction by proteasome-mediated degradation, but the mammalian ubiquitin machinery involved is incompletely understood. Here, using forward genetic screens in human cells, we find that the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72735d88d08f1ccdb03a5bfbc46d92d3
https://www.repository.cam.ac.uk/handle/1810/275453
https://www.repository.cam.ac.uk/handle/1810/275453
Autor:
Stefanovic‐Barrett, Sandra, Dickson, Anna S, Burr, Stephen P, Williamson, James C, Lobb, Ian T, van den Boomen, Dick JH, Lehner, Paul J, Nathan, James A
Publikováno v:
EMBO Reports
Misfolded or damaged proteins are typically targeted for destruction by proteasome‐mediated degradation, but the mammalian ubiquitin machinery involved is incompletely understood. Here, using forward genetic screens in human cells, we find that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22277d8d62e2475689aeb9f286c6ed47
http://europepmc.org/articles/PMC5934766
http://europepmc.org/articles/PMC5934766
Autor:
Menzies, Sam A, Volkmar, Norbert, Van Den Boomen, Dick Jh, Timms, Richard T, Dickson, Anna S, Nathan, James A, Lehner, Paul J
UNLABELLED: Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22582d2d75a206dc4bb38dd8c9453b46
Autor:
Van Den Boomen, Dick JH, Sienkiewicz, Agata, Berlin, Ilana, Jongsma, Marlieke LM, Van Elsland, Daphne M, Luzio, J Paul, Neefjes, Jacques JC, Lehner, Paul J
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab721c9c24e51f0abbba25368cf87e0
Autor:
Ilana Berlin, Agata Sienkiewicz, Paul J. Lehner, Dick J. H. van den Boomen, Marlieke L.M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques Neefjes
Publikováno v:
Nature Communications
Nature Communications, 11(1). NATURE RESEARCH
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 11(1). NATURE RESEARCH
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2d8cd870120ef7d7703dbb0df2c6f0