High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases.

Autor: Jia X; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Crawford JC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: jeremy.crawford@stjude.org., Gebregzabher D; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Monson EA; Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia., Mettelman RC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wan Y; Shanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai 201508, China., Ren Y; Shanghai Public Health Clinical Centre, Fudan University, Shanghai 201508, China., Chou J; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA., Novak T; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA., McQuilten HA; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Clarke M; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Bachem A; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Foo IJ; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Fritzlar S; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Carrera Montoya J; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Trenerry AM; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Nie S; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3052, Australia., Leeming MG; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3052, Australia., Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Kedzierski L; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Littler DR; Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Kueh A; Walter Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Bundoora, VIC 3086, Australia., Cardamone T; Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC 3010, Australia., Wong CY; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Hensen L; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Cabug A; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Laguna JG; Department of Anatomy and Comparative Pathology and Toxicology, Pathology and Immunology Group, University of Córdoba, International Excellence Agrifood Campus 'CeiA3', 14014 Córdoba, Spain., Agrawal M; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Flerlage T; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Boyd DF; Department of Molecular, Cell & Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Van de Velde LA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Habel JR; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Loh L; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Koay HF; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., van de Sandt CE; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Konstantinov IE; Department of Cardiothoracic Surgery, Royal Children's Hospital, University of Melbourne, Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Parkville, VIC 3052, Australia., Berzins SP; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC 3353, Australia., Flanagan KL; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia; School of Health and Biomedical Science, RMIT University, Bundoora, VIC 3083, Australia; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS 7250, Australia., Wakim LM; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Herold MJ; Walter Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Bundoora, VIC 3086, Australia., Green AM; Center for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Smallwood HS; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Rossjohn J; Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff, UK., Thwaites RS; National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK., Chiu C; Department of Infectious Disease, Imperial College London, London, UK., Scott NE; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Mackenzie JM; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Bedoui S; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Reading PC; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Londrigan SL; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia., Helbig KJ; Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia., Randolph AG; Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA 02115, USA; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA., Thomas PG; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Infectious Diseases Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA., Xu J; Shanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University, Shanghai 201508, China., Wang Z; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, China. Electronic address: wangzhongfang@gird.cn., Chua BY; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Electronic address: bychua@unimelb.edu.au., Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Center for Influenza Disease and Emergence Response (CIDER), Athens, GA, USA. Electronic address: kkedz@unimelb.edu.au.

Publikováno v: Cell [Cell] 2024 Aug 22; Vol. 187 (17), pp. 4586-4604.e20. Date of Electronic Publication: 2024 Aug 12.

Necroptosis blockade prevents lung injury in severe influenza.

Autor: Gautam A; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Boyd DF; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA., Nikhar S; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA., Zhang T; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Siokas I; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA., Van de Velde LA; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Gaevert J; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Meliopoulos V; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Thapa B; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Rodriguez DA; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Cai KQ; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Yin C; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Schnepf D; Institute of Virology Department for Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Beer J; Institute of Virology Department for Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany., DeAntoneo C; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Williams RM; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Shubina M; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Livingston B; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Zhang D; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA., Andrake MD; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA., Lee S; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA., Boda R; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA., Duddupudi AL; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA., Crawford JC; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Vogel P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Loch C; Reaction Biology, Malvern, PA, USA., Schwemmle M; Institute of Virology Department for Medical Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Fritz LC; Vaayu Therapeutics, Rancho Santa Fe, CA, USA., Schultz-Cherry S; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Green DR; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA. gdcuny@central.uh.edu., Thomas PG; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA. paul.thomas@stjude.org.; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA. paul.thomas@stjude.org., Degterev A; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA. alexei.degterev@tufts.edu., Balachandran S; Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA. Siddharth.balachandran@fccc.edu.

Publikováno v: Nature [Nature] 2024 Apr; Vol. 628 (8009), pp. 835-843. Date of Electronic Publication: 2024 Apr 10.

Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma.

Autor: Abu-Zaid A; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA., Fang J; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Jin H; Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Singh S; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Pichavaram P; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Wu Q; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Tillman H; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Janke L; Department of Pathology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Rosikiewicz W; Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Xu B; Center for Applied Bioinformatics, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Van De Velde LA; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Guo Y; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Li Y; Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Shendy NAM; Department of Molecular Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Delahunty IM; Department of Molecular Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Rankovic Z; Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Chen T; Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Chen X; Department of Computational Biology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Freeman KW; Genetics, Genomics & Informatics, The University of Tennessee Health Science Center, Memphis, TN 38103, USA., Hatley ME; Department of Molecular Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Durbin AD; Department of Molecular Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Murray PJ; Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany., Murphy AJ; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA., Thomas PG; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA., Davidoff AM; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38105, USA; St Jude Graduate School of Biomedical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Pathology and Laboratory Medicine, College of Medicine, The University of Tennessee Health Science Center, 930 Madison Avenue, Suite 500, Memphis, TN 38163, USA., Yang J; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105, USA; St Jude Graduate School of Biomedical Sciences, St Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Pathology and Laboratory Medicine, College of Medicine, The University of Tennessee Health Science Center, 930 Madison Avenue, Suite 500, Memphis, TN 38163, USA; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: jun.yang2@stjude.org.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Mar 19; Vol. 5 (3), pp. 101468.

Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models.

Autor: Singh S; Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Quarni W; Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Goralski M; Department of Internal Medicine, Program in Molecular Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. K3.124, Dallas, TX 75390, USA., Wan S; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Jin H; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Van de Velde LA; Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Fang J; Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Wu Q; Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Abu-Zaid A; Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Wang T; Center for Childhood Cancer and Blood Disease, Abigail Wexner Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA., Singh R; Division of Radiation Biophysics, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Craft D; Division of Radiation Biophysics, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Fan Y; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Confer T; Center for In Vivo Imaging and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Johnson M; Center for In Vivo Imaging and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Akers WJ; Center for In Vivo Imaging and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Wang R; Center for Childhood Cancer and Blood Disease, Abigail Wexner Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA., Murray PJ; Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany., Thomas PG; Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Nijhawan D; Department of Internal Medicine, Program in Molecular Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. K3.124, Dallas, TX 75390, USA., Davidoff AM; Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Yang J; Department of Surgery, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

Publikováno v: Science advances [Sci Adv] 2021 Nov 19; Vol. 7 (47), pp. eabj5405. Date of Electronic Publication: 2021 Nov 17.

Absence of β6 Integrin Reduces Influenza Disease Severity in Highly Susceptible Obese Mice.

Autor: Meliopoulos V; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Livingston B; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Van de Velde LA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Honce R; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Microbiology, Immununology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA., Schultz-Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA Stacey.schultz-cherry@stjude.org.

Publikováno v: Journal of virology [J Virol] 2019 Jan 04; Vol. 93 (2). Date of Electronic Publication: 2019 Jan 04 (Print Publication: 2019).