Cyclooxygenases as Potential PET Imaging Biomarkers to Explore Neuroinflammation in Dementia

Autor: Kenou, Bruny V., Manly, Lester S., Rubovits, Sara B., Umeozulu, Somachukwu A., Van Buskirk, Maia G., Zhang, Andrea S., Pike, Victor W., Zanotti-Fregonara, Paolo, Henter, Ioline D., Innis, Robert B.

Publikováno v: J Nucl Med

The most frequently studied target of neuroinflammation using PET is 18-kDa translocator protein, but its limitations have spurred the molecular imaging community to find more promising targets. This article reviews the development of PET radioligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646e92f9485ca1ee9646a347bf2612e3
https://doi.org/10.2967/jnumed.121.263199

In vivo evaluation of a novel ¹⁸F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain.

Autor: Yan, Xuefeng, Siméon, Fabrice G., Liow, Jeih-San, Morse, Cheryl L., Montero Santamaria, Jose A., Jenkins, Madeline, Manly, Lester S., Van Buskirk, Maia, Zoghbi, Sami S., Pike, Victor W., Innis, Robert B., Zanotti-Fregonara, Paolo

Publikováno v: European Journal of Nuclear Medicine & Molecular Imaging; Aug2023, Vol. 50 Issue 10, p2962-2970, 9p, 1 Color Photograph, 1 Diagram, 1 Chart, 4 Graphs

First-in-Human Evaluation of ¹⁸F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B.

Autor: Yuichi Wakabayashi, Stenkrona, Per, Arakawa, Ryosuke, Xuefeng Yan, Van Buskirk, Maia G., Jenkins, Madeline D., Santamaria, Jose A. Montero, Maresca, Kevin P., Akihiro Takano, Liow, Jeih-San, Chappie, Thomas A., Varrone, Andrea, Nag, Sangram, Lei Zhang, Hughes, Zoë A., Schmidt, Christopher J., Doran, Shawn D., Mannes, Andrew, Zanotti-Fregonara, Paolo, Ooms, Maarten

Publikováno v: Journal of Nuclear Medicine; Dec2022, Vol. 63 Issue 12, p1919-1924, 6p

175. A Novel 18F-Labeled Pet Radioligand Accurately Quantifies Translocator Protein 18kDa (TSPO) in Monkey Brain

Autor: Jenkins, Madeline, Yan, Xuefeng, Siméon, Fabrice, Liow, Jeih-San, Morse, Cheryl, Santamaria, Jose Montero, Manly, Lester, Van Buskirk, Maia, Zoghbi, Sami, Pike, Victor, Innis, Robert, Zanotti-Fregonara, Paolo

Publikováno v: In Biological Psychiatry 1 May 2023 93(9) Supplement:S165-S165

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