Zobrazeno 1 - 10
of 530
pro vyhledávání: '"Van Boom JH"'
Publikováno v:
Journal of Medicinal Chemistry. 38:1538-1546
High-affinity ligands for the asialoglycoprotein receptor, which is uniquely localized on the parenchymal liver cell and recognizes oligoantennary galactosides, might be utilized as homing device to specifically target drugs or genes to parenchymal l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd66f5e92e05d77587600530317fad9
https://doi.org/10.1021/jm00009a014
https://doi.org/10.1021/jm00009a014
Publikováno v:
Organic Letters. 3:731-733
The cyclooctenol derivative 1 can be transformed into the nine-membered ring lactone 3, as well as the amino-containing carbocycles 4 and 5. The corresponding ketone 2 gives access to the conformationally locked azasugar 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::993786d42e121668966f9c5e851ebf3c
https://doi.org/10.1021/ol007047+
https://doi.org/10.1021/ol007047+
Publikováno v:
Bioconjugate chemistry. 11(6)
This work describes the first automated solid-phase synthesis of metal derivatives of peptide nucleic acid (PNA) oligomers and their interaction with DNA and PNA. PNA constitutes a relatively young and very promising class of DNA analogues with excel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cad89c13f1bd35718c2f4566ce79b6
https://pubmed.ncbi.nlm.nih.gov/11087319
https://pubmed.ncbi.nlm.nih.gov/11087319
Publikováno v:
Angewandte Chemie (International ed. in English). 39(17)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1e4f2f329a3906776e5fa2c3e242926
https://pubmed.ncbi.nlm.nih.gov/11028044
https://pubmed.ncbi.nlm.nih.gov/11028044
Autor:
van Boom Jh, Michiel A. Leeuwenburgh, Remy E. J. N. Litjens, van der Marel Ga, Herman S. Overkleeft, Jeroen D. C. Codée
Publikováno v:
Organic letters. 2(9)
[formula: see text] Tributyltin radical mediated cyclization of carbohydrate-derived beta-(alkynyloxy)acrylates leading to highly functionalized cis- and trans-fused bicyclic ethers of various ring sizes is described. The efficacy of the radical cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187f27d335a847dd3b1fbfc7507770f1
https://pubmed.ncbi.nlm.nih.gov/10810726
https://pubmed.ncbi.nlm.nih.gov/10810726
Publikováno v:
Angewandte Chemie (International ed. in English). 39(2)
Cross-linking ability is possible with the oligonucleotide-tethered, monofunctional trans-Pt(II) complex shown. It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2)Pt(II) buil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7813ddd790ae5f18c6b77f5679be9ccd
https://pubmed.ncbi.nlm.nih.gov/10649415
https://pubmed.ncbi.nlm.nih.gov/10649415
Publikováno v:
Angewandte Chemie (International ed. in English). 39(2)
The introduction of a urea bond linking a protected diethylenetriamine (DETA) unit and the terminal amino group of a resin-bound peptide nucleic acid (PNA) decamer gave access to a PNA - DETA adduct (shown here), which hydrolyzed the target 25-mer RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6813f899178467ca7645b94cea0c0e52
https://pubmed.ncbi.nlm.nih.gov/10649413
https://pubmed.ncbi.nlm.nih.gov/10649413
Autor:
van den Elst Ha, van der Marel Ga, van Boom Jh, van de Wetering Ki, Stuivenberg Hr, van der Kaaden Jc, Nico J. Meeuwenoord, Geri F. Moolenaar, R. Visse, Monaco, Nora Goosen, Esther E.A. Verhoeven
Publikováno v:
Nucleosidesnucleotides. 18(6-7)
Three new cholesterol-containing phosphoramidites where synthesized and used in automated synthesis of modified DNA fragments. These cholesterol lesions are good substrates for the E. coli UvrABC endonuclease. In vitro they are incised from damaged D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863c78de11f6afd7edec7464d2606227
https://pubmed.ncbi.nlm.nih.gov/10474222
https://pubmed.ncbi.nlm.nih.gov/10474222
Autor:
van der Marel Ga, van Boom Jh, Guido V. Bloemberg, van Leeuwen S, Lagas Rm, Ben J. J. Lugtenberg, Herman P. Spaink
Publikováno v:
Biochemistry. 34(39)
All lipo-chitin oligosaccharides identified from Rhizobium leguminosarum carry an O-acetyl moiety on C6 of the nonreducing terminal N-acetylglucosamine residue. Previously, we have shown that purified NodL protein, using acetyl-CoA as acetyl donor, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc85841aa21c5744adcd0050d899ff9
https://pubmed.ncbi.nlm.nih.gov/7548024
https://pubmed.ncbi.nlm.nih.gov/7548024
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