Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Van Bergen en Henegouwen, P."'
Autor:
Valérie L. B. I. Jansen, Dagmar J. M. van Mourik, Mark Davids, Kika van Bergen en Henegouwen, Tessa Noordermeer, Johannes H. M. Levels, Maarten Limper, Michiel Coppens, Max Nieuwdorp, Rolf T. Urbanus, Saskia Middeldorp, Thijs E. van Mens
Publikováno v:
TH Open, Vol 08, Iss 03, Pp e308-e316 (2024)
Background The origin of autoantibodies in patients with antiphospholipid syndrome (APS) is unknown. The gut microbiome contributes to autoimmunity and contains peptide homologues to the main APS autoantigen, which affect disease activity in animal m
Externí odkaz:
https://doaj.org/article/6f08506fc2544e6586f13a52920f26bd
Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies
Autor:
Jord C. Stam, Steven de Maat, Dorien de Jong, Mathia Arens, Fenna van Lint, Lavina Gharu, Mark H. van Roosmalen, Rob C. Roovers, Nika M. Strokappe, Ralf Wagner, Alexander Kliche, Hans J. de Haard, Paul M. van Bergen en Henegouwen, Monique Nijhuis, C. Theo Verrips
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract While vaccination against HIV-1 has been so far unsuccessful, recently broadly neutralizing antibodies (bNAbs) against HIV-1 envelope glycoprotein were shown to induce long-term suppression in the absence of antiretroviral therapy in patient
Externí odkaz:
https://doaj.org/article/ffdba455ddae44ce8e6074f6be3806a7
Akademický článek
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Autor:
Matthieu R. Zeronian, Sofia Doulkeridou, Paul M. P. van Bergen en Henegouwen, Bert J. C. Janssen
Publikováno v:
BMC Molecular and Cell Biology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background The epidermal growth factor receptor (EGFR) is involved in various developmental processes, and alterations of its extracellular segment are associated with several types of cancers, in particular glioblastoma multiforme (GBM). Th
Externí odkaz:
https://doaj.org/article/97e603dd6d3c4ad188f414b157bf599d
Autor:
Beltrán Hernández Irati, Grinwis Guillaume C.M., Di Maggio Alessia, van Bergen en Henegouwen Paul M.P., Hennink Wim E., Teske Erik, Hesselink Jan W., van Nimwegen Sebastiaan A., Mol Jan A., Oliveira Sabrina
Publikováno v:
Nanophotonics, Vol 10, Iss 12, Pp 3075-3087 (2021)
Nanobody-targeted photodynamic therapy (NB-PDT) has been developed as a potent and tumor-selective treatment, using nanobodies (NBs) to deliver a photosensitizer (PS) specifically to cancer cells. Upon local light application, reactive oxygen species
Externí odkaz:
https://doaj.org/article/f58c8c98f65a4529b69db80246a8c501
Autor:
Jansen, Valérie L. B. I., van Mourik, Dagmar J. M., Davids, Mark, van Bergen en Henegouwen, Kika, Noordermeer, Tessa, Levels, Johannes H. M., Limper, Maarten, Coppens, Michiel, Nieuwdorp, Max, Urbanus, Rolf T., Middeldorp, Saskia, van Mens, Thijs E.
Publikováno v:
TH Open; July 2024, Vol. 8 Issue: 3 pe308-e316, 9p
Autor:
Marta Compte, Seandean L. Harwood, Jorge Martínez-Torrecuadrada, Gema Perez-Chacon, Patricia González-García, Antonio Tapia-Galisteo, Paul M. P. Van Bergen en Henegouwen, Aránzazu Sánchez, Isabel Fabregat, Laura Sanz, Juan M. Zapata, Luis Alvarez-Vallina
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Agonistic monoclonal antibodies (mAbs) targeting the co-stimulatory receptor 4-1BB are among the most effective immunotherapeutic agents across pre-clinical cancer models. However, clinical development of full-length 4-1BB agonistic mAbs, has been ha
Externí odkaz:
https://doaj.org/article/73fed565702c4bd49e60af922d155683
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Autor:
Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the in
Externí odkaz:
https://doaj.org/article/d8f1227aa2394ee08a80e9812006d6b2
Autor:
Sebas D. Pronk, Erik Schooten, Jurgen Heinen, Esra Helfrich, Sabrina Oliveira, Paul M. P. van Bergen en Henegouwen
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 927 (2021)
Antibody-drug conjugates (ADCs) are currently used for the targeted delivery of drugs to diseased cells, but intracellular drug delivery and therefore efficacy may be suboptimal because of the large size, slow internalization and ineffective intracel
Externí odkaz:
https://doaj.org/article/95ef8bcfe44545c58131513ea26908a0
Autor:
Eugene A. Katrukha, Marina Mikhaylova, Hugo X. van Brakel, Paul M. van Bergen en Henegouwen, Anna Akhmanova, Casper C. Hoogenraad, Lukas C. Kapitein
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Methods to probe transport dynamics within cells can shed insight into the nature of the cytoplasm. Here the authors develop a method to functionalize and deliver quantum dots intracellularly to show how the cytoskeleton influences non-equilibrium in
Externí odkaz:
https://doaj.org/article/a471b41a01894b80a775b59d0e03eae6