High-rate pacing suppresses Torsade de Pointes arrhythmias and reduces spatial dispersion of repolarization in the chronic AV-block dog model.

Autor: Loen V; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Van Weperen VYH; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Beekman HDM; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Van Bavel JJA; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Meijborg VMF; Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, Netherlands., Van der Waal JG; Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, Netherlands., Coronel R; Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, Netherlands., van der Heyden MAG; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Vos MA; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands.

Publikováno v: Frontiers in physiology [Front Physiol] 2023 Dec 20; Vol. 14, pp. 1330230. Date of Electronic Publication: 2023 Dec 20 (Print Publication: 2023).

Remodeling in the AV block dog is essential for tolerating moderate treadmill activity.

Autor: van Bavel JJA; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands., Beekman HDM; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands., Schot A; Department of Clinical Sciences, Division of Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University, the Netherlands., Wouters PC; Department of Cardiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., van Emst MG; Department of Clinical Sciences, Division of Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University, the Netherlands., Takken T; Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands., van der Heyden MAG; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands., Vos MA; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, the Netherlands.

Publikováno v: International journal of cardiology. Heart & vasculature [Int J Cardiol Heart Vasc] 2023 Jan 03; Vol. 44, pp. 101169. Date of Electronic Publication: 2023 Jan 03 (Print Publication: 2023).

PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model.

Autor: van Bavel JJA; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Pham C; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Beekman HDM; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Houtman MJC; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Bossu A; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Sparidans RW; Division Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands., van der Heyden MAG; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Vos MA; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Aug 03; Vol. 9, pp. 956538. Date of Electronic Publication: 2022 Aug 03 (Print Publication: 2022).

Flotillins in the intercalated disc are potential modulators of cardiac excitability.

Autor: Kessler EL; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: e.l.kessler@umcutrecht.nl., van Stuijvenberg L; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., van Bavel JJA; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., van Bennekom J; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Zwartsen A; Dutch Poisons Information Center (DPIC), University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Rivaud MR; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Vink A; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Efimov IR; Department of Biomedical Engineering, George Washington University, Washington, DC, USA., Postma AV; Department of Clinical Genetics, Amsterdam University Medical Center, Location AMC, the Netherlands., van Tintelen JP; Department of Clinical Genetics, Amsterdam University Medical Center, Location AMC, the Netherlands; Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands., Remme CA; Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands., Vos MA; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Banning A; Institute of Biochemistry, Medical Faculty, University of Giessen, Germany., de Boer TP; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Tikkanen R; Institute of Biochemistry, Medical Faculty, University of Giessen, Germany., van Veen TAB; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2019 Jan; Vol. 126, pp. 86-95. Date of Electronic Publication: 2018 Nov 17.

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.

Autor: Cerrone M; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Montnach J; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Lin X; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Zhao YT; Center for Arrhythmia Research, Division of Cardiology, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA., Zhang M; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Agullo-Pascual E; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Leo-Macias A; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Alvarado FJ; Department of Molecular and Integrative Physiology, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA., Dolgalev I; Genome Technology Center, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Karathanos TV; Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, 3400N Charles St., Baltimore, MD, 21218, USA., Malkani K; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Van Opbergen CJM; Department of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht, Yalelaan 50, 3584CM, Utrecht, The Netherlands., van Bavel JJA; Department of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht, Yalelaan 50, 3584CM, Utrecht, The Netherlands., Yang HQ; Department of Pediatrics, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Vasquez C; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Tester D; Departments of Cardiovascular Diseases/Division of Heart Rhythm Services, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Department of Pediatric and Adolescent Medicine/Division of Pediatric Cardiology, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Fowler S; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Liang F; Department of Cell Biology and Microscopy Core, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Rothenberg E; Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Heguy A; Genome Technology Center, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Morley GE; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Coetzee WA; Departments of Pediatrics, Physiology & Neuroscience and Biochemistry and Molecular Pharmacology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA., Trayanova NA; Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, 3400N Charles St., Baltimore, MD, 21218, USA., Ackerman MJ; Departments of Cardiovascular Diseases/Division of Heart Rhythm Services, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Department of Pediatric and Adolescent Medicine/Division of Pediatric Cardiology, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., van Veen TAB; Department of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht, Yalelaan 50, 3584CM, Utrecht, The Netherlands., Valdivia HH; Center for Arrhythmia Research, Division of Cardiology, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA., Delmar M; Leon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA. Mario.delmar@nyumc.org.

Publikováno v: Nature communications [Nat Commun] 2017 Jul 24; Vol. 8 (1), pp. 106. Date of Electronic Publication: 2017 Jul 24.