SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability.

Autor: Lettieri A; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy.; Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142, Milano, Italy., Oleari R; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy., van den Munkhof MH; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands., van Battum EY; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands., Verhagen MG; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands.; VIB-KU Leuven, Center for Brain & Disease Research, Leuven, Belgium., Tacconi C; Department of Biosciences, University of Milan, Via Celoria 26, 20133, Milan, Italy.; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Spreafico M; Department of Biosciences, University of Milan, Via Celoria 26, 20133, Milan, Italy., Paganoni AJJ; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy., Azzarelli R; Wellcome - Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK., Andre' V; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy., Amoruso F; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy., Palazzolo L; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy., Eberini I; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy., Dunkel L; Centre for Endocrinology William Harvey Research Institute Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Howard SR; Centre for Endocrinology William Harvey Research Institute Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Department of Paediatric Endocrinology, Barts Health NHS Trust, London, E1 1FR, UK., Fantin A; Department of Biosciences, University of Milan, Via Celoria 26, 20133, Milan, Italy. alessandro.fantin@unimi.it., Pasterkamp RJ; Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands. r.j.pasterkamp@umcutrecht.nl., Cariboni A; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy. anna.cariboni@unimi.it.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 07; Vol. 14 (1), pp. 8097. Date of Electronic Publication: 2023 Dec 07.

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.

Autor: Robinson RA; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Griffiths SC; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., van de Haar LL; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Malinauskas T; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., van Battum EY; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Zelina P; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Schwab RA; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Karia D; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Malinauskaite L; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK., Brignani S; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., van den Munkhof MH; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Düdükcü Ö; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., De Ruiter AA; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Van den Heuvel DMA; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Bishop B; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Elegheert J; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK., Aricescu AR; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK., Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands. Electronic address: r.j.pasterkamp@umcutrecht.nl., Siebold C; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address: christian@strubi.ox.ac.uk.

Publikováno v: Cell [Cell] 2021 Apr 15; Vol. 184 (8), pp. 2103-2120.e31. Date of Electronic Publication: 2021 Mar 18.

DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells.

Autor: Harterink M; Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands., da Silva ME; Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Will L; Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Turan J; Department of Neurobiology, Stanford University School of Medicine, Stanford, California, USA., Ibrahim A; Department of Neurobiology, Stanford University School of Medicine, Stanford, California, USA., Lang AE; Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs University of Freiburg, Freiburg, Germany., van Battum EY; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., Kapitein LC; Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Kudryashov D; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA., Barres BA; Department of Neurobiology, Stanford University School of Medicine, Stanford, California, USA., Hoogenraad CC; Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Zuchero JB; Department of Neurobiology, Stanford University School of Medicine, Stanford, California, USA.; Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.

Publikováno v: Nature methods [Nat Methods] 2017 May; Vol. 14 (5), pp. 479-482. Date of Electronic Publication: 2017 Apr 10.

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.

Autor: van Erp S; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands., van den Heuvel DMA; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands., Fujita Y; Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan., Robinson RA; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Hellemons AJCGM; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands., Adolfs Y; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands., Van Battum EY; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands., Blokhuis AM; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands., Kuijpers M; Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, the Netherlands., Demmers JAA; Proteomics Centre and Department of Cell Biology, Erasmus University Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, the Netherlands., Hedman H; Oncology Research Laboratory, Department of Radiation Sciences, Umeå University, 90187 Umeå, Sweden., Hoogenraad CC; Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, the Netherlands., Siebold C; Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Yamashita T; Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan., Pasterkamp RJ; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands. Electronic address: r.j.pasterkamp@umcutrecht.nl.

Publikováno v: Developmental cell [Dev Cell] 2015 Dec 07; Vol. 35 (5), pp. 537-552.

The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections.

Autor: Van Battum EY; 1] Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands [2]., Gunput RA; 1] Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands [2] [3]., Lemstra S; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands., Groen EJ; 1] Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands [2] Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands., Yu KL; Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands., Adolfs Y; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands., Zhou Y; 1] Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands [2]., Hoogenraad CC; Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands., Yoshida Y; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA., Schachner M; Center for Neuroscience, Shantou University Medical College, Shantou, Guangdong 515041, China., Akhmanova A; Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.

Publikováno v: Nature communications [Nat Commun] 2014 Jul 10; Vol. 5, pp. 4317. Date of Electronic Publication: 2014 Jul 10.