Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Van Barnes"'
Autor:
Akshita B. Bhatt, Thomas D. Wright, Van Barnes, Suravi Chakrabarty, Margarite D. Matossian, Erin Lexner, Deniz A. Ucar, Lucio Miele, Patrick T. Flaherty, Matthew E. Burow, Jane E. Cavanaugh
Publikováno v:
Translational Oncology, Vol 14, Iss 6, Pp 101046- (2021)
The epithelial to mesenchymal transition (EMT) is characterized by a loss of cell polarity, a decrease in the epithelial cell marker E-cadherin, and an increase in mesenchymal markers including the zinc-finger E-box binding homeobox (ZEB1). The EMT i
Externí odkaz:
https://doaj.org/article/741a151b8f16497b82667f09411e6156
Autor:
Jane E. Cavanaugh, Patrick T. Flaherty, Lucio Miele, Margarite D. Matossian, Thomas D. Wright, Van Barnes, Matthew E. Burow, Deniz A. Ucar, Suravi Chakrabarty, Akshita B. Bhatt, Erin Lexner
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 6, Pp 101046-(2021)
Translational Oncology, Vol 14, Iss 6, Pp 101046-(2021)
Highlights • ERK1/2 and ERK5 pathway inhibition induces mesenchymal to epithelial transition in breast cancer. • ERK5 is endogenously active and localized in the nucleus of TNBC cells. • Dual ERK5 and ERK1/2 or AKT inhibition is a relevant stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae42aa562776ae0dc9e5bd5217344a1a
https://lirias.kuleuven.be/handle/20.500.12942/707698
https://lirias.kuleuven.be/handle/20.500.12942/707698
Autor:
Thomas D. Wright, Patrick T. Flaherty, Matthew E. Burow, Jane E. Cavanaugh, Akshita B. Bhatt, Van Barnes, Suravi Chakrabarty
Publikováno v:
Cancer Research. 80:5042-5042
Extracellular signal-regulated kinase (ERK) 5, a member of mitogen activated protein kinase (MAPK) family, is an emerging target in cancer therapeutics. Activation of ERK5 via overexpression induces EMT and hormone-independent growth of breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d08cb308d8e5731e308a48e73f611e
https://doi.org/10.1158/1538-7445.am2020-5042
https://doi.org/10.1158/1538-7445.am2020-5042
Autor:
Jane E. Cavanaugh, Akshita B. Bhatt, Van Barnes, Suravi Chakrabarty, Thomas D. Wright, Saloni Patel, Matthew E. Burow, Patrick T. Flaherty
Publikováno v:
Molecular Cancer Therapeutics. 18:B078-B078
Triple negative breast cancer is characterized by the loss of hormone receptors and lack of targeted therapy. Most invasive cancers, including triple negative (TNBC) breast cancer have a mesenchymal phenotype, which is associated with increased chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05b8271b25e898bf523f691519ff945a
https://doi.org/10.1158/1535-7163.targ-19-b078
https://doi.org/10.1158/1535-7163.targ-19-b078
Autor:
Jane E. Cavanaugh, Fahima Munmun, Thomas D. Wright, Kevin M. Middleton, Sarah J. Peacock, Van Barnes, Matthew E. Burow, Paula A. Witt-Enderby
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6de71fce241c17eb0d17ac4bece641
https://doi.org/10.1096/fasebj.2018.32.1_supplement.644.20
https://doi.org/10.1096/fasebj.2018.32.1_supplement.644.20
Autor:
Patrick T. Flaherty, Hope E. Burks, Van Barnes, Lucio Miele, Thomas D. Wright, Deniz A. Ucar-Bilyeu, Jane E. Cavanaugh, Matthew E. Burow, Mohit Gupta, Margarite D. Matossian, Fokhrul Hossain
Publikováno v:
Cancer Research. 78:967-967
Triple negative breast cancer (TNBC) is a molecularly heterogeneous, clinically aggressive disease group that is highly prevalent among African-Americans and younger patients. Standard chemo/radio therapy often produces clinical responses, but recurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::685f186905924cb2a7496a2417e1eac7
https://doi.org/10.1158/1538-7445.am2018-967
https://doi.org/10.1158/1538-7445.am2018-967
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