Preclinical assessment of combined BCL-2 and MCL-1 inhibition in high-risk neuroblastoma

Autor: Lindy Vernooij, Alvin Kamili, Kimberley Ober, Jennemiek van Arkel, Lina Lankhorst, Enya Vermeulen, Hanin Al-Khakany, Gabor Tax, Marlinde L. van den Boogaard, Jamie I. Fletcher, Selma Eising, Jan J. Molenaar, M. Emmy M. Dolman

Publikováno v: EJC Paediatric Oncology, Vol 3, Iss , Pp 100168- (2024)

Background: Neuroblastoma is the most common extracranial pediatric solid malignancy with high-risk patients showing survival rates less than 50 %. These tumors frequently escape apoptosis through upregulation of the anti-apoptotic protein BCL-2. Unf

Externí odkaz: https://doaj.org/article/248810243e214da890e1924fb4d60647

Upfront resection versus no resection of the primary tumor in patients with synchronous metastatic colorectal cancer: the randomized phase III CAIRO4 study conducted by the Dutch Colorectal Cancer Group and the Danish Colorectal Cancer Group

Autor: Vincent, Jeroen, Wegdam, Johannes A., Haberkorn, Brigitte C.M., van der Harst, Erwin, Hendriks, Mathijs P., Schreurs, W.H. Hermien, Cense, Huib A., Rietbroek, Ron C., de Gier, Marie-José, van Breugel, Edwin A., de Vos, Aad I., Brosens, Rebecca P.M., Doornebosch, P.G., de Jongh, Felix E., Vles, Wouter J., den Boer, Marien O., Leijtens, Jeroen W.A., Gelderblom, A.J. Hans, Peeters, Koen C.M.J., Kuenen, Bart C., Pultrum, Bareld B., van Dodewaard-de Jong, Joyce M., Consten, Esther C.J., van de Wouw, A.J. Yes, Konsten, J.L.M., Hoekstra, R., Lutke Holzik, Martijn F., Vos, Allert H., van Hoogstraten, M.J., Schlesinger, Nis H., Creemers, Geert-Jan, de Hingh, Ignace H.J.T., Kjær, Monica L., Petersen, Lone N., Seiersen, Michael, Altaf, Rahim, van Cruijsen, Hester, Hess, Daniël A., van Leeuwen-Snoeks, Lobke L., Pronk, Apollo, Baeten, Coen I.M., van der Deure, Wendy M., Bosscha, Koop, Schut, Heidi, Leclercq, W.K.G., Simkens, L.H.J., Reijnders, Koen, van Arkel, Kees, van Grevenstein, W.M.U. Helma, van de Ven, Anthony W.H., Vuylsteke, Ronald J.C.L.M., Kuijer, Philomeen, Bakker, Sandra D., Goei, Hauwy, Helgason, Helgi H., van Acker, Gijs J.D., Temizkan, Mehmet, van Tilburg, Marc W.A., Gerhards, Michael F., Kerver, E.D., Gootjes, Elske, Nieboer, Peter, Bleeker, Wim A., Bleeker, G.R., van der Kruijssen, D.E.W., Elias, S.G., van de Ven, P.M., van Rooijen, K.L., Lam-Boer, J.’t, Mol, L., Punt, C.J.A., Sommeijer, D.W., Tanis, P.J., Nielsen, J.D., Yilmaz, M.K., van Riel, J.M.G.H., Wasowiz-Kemps, D.K., Loosveld, O.J.L., van der Schelling, G.P., de Groot, J.W.B., van Westreenen, H.L., Jakobsen, H.L., Fromm, A.L., Hamberg, P., Verseveld, M., Jaensch, C., Liposits, G.I., van Duijvendijk, P., Oulad Hadj, J., van der Hoeven, J.A.B., Trajkovic, M., de Wilt, J.H.W., Koopman, M.

Publikováno v: In Annals of Oncology September 2024 35(9):769-779

An Optimization Approach for Creating Application-specific Ultrasound Speckle Tracking Algorithms

Autor: Kuder, Isabelle M., Rock, Mick, Jones, Gareth G., Amis, Andrew A., Cegla, Frederic B., van Arkel, Richard J.

Publikováno v: In Ultrasound in Medicine & Biology August 2024 50(8):1108-1121

Stakeholder perspectives on contributors to delayed and inaccurate diagnosis of cardiovascular disease and their implications for digital health technologies: a UK-based qualitative study

Autor: Faith Matcham, Timothy Chico, Kamilla Abdullayev, Olivia Gorvett, Anna Sochiera, Matthew Manktelow, Oliver Buckley, Joan Condell, Vanessa Diaz, Lynn Laidlaw, Richard Van Arkel

Publikováno v: BMJ Open, Vol 14, Iss 5 (2024)

Objective The aim of this study is to understand stakeholder experiences of diagnosis of cardiovascular disease (CVD) to support the development of technological solutions that meet current needs. Specifically, we aimed to identify challenges in the

Externí odkaz: https://doaj.org/article/fa5db3ab7c464566bb9321e6662cfecf

Load transfer in bone after partial, multi-compartmental, and total knee arthroplasty

Autor: Jennifer C. Stoddart, Amy Garner, Mahmut Tuncer, Andrew A. Amis, Justin Cobb, Richard J. van Arkel

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Introduction: Arthroplasty-associated bone loss remains a clinical problem: stiff metallic implants disrupt load transfer to bone and, hence, its remodeling stimulus. The aim of this research was to analyze how load transfer to bone is affected by di

Externí odkaz: https://doaj.org/article/1e0f79ab52f04ca4be704bf3e50db7fc