Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Vamsi K. Gali"'
Publikováno v:
Cell Reports, Vol 16, Iss 3, Pp 684-695 (2016)
Loss of the genome maintenance factor Elg1 causes serious genome instability that leads to cancer, but the underlying mechanism is unknown. Elg1 forms the major subunit of a replication factor C-like complex, Elg1-RLC, which unloads the ring-shaped p
Externí odkaz:
https://doaj.org/article/314a0108832b4806ad4dcc04ec7580a6
Autor:
Orsolya Frittmann, Vamsi K Gali, Miklos Halmai, Robert Toth, Zsuzsanna Gyorfy, Eva Balint, Ildiko Unk
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)
AbstractDNA damages that hinder the movement of the replication complex can ultimately lead to cell death. To avoid that, cells possess several DNA damage bypass mechanisms. The Rad18 ubiquitin ligase controls error-free and mutagenic pathways that h
Externí odkaz:
https://doaj.org/article/74a6ff618a8e42b593dc342d806f0dce
Autor:
Vamsi K Gali, David Dickerson, Yuki Katou, Katsunori Fujiki, Katsuhiko Shirahige, Tom Owen-Hughes, Takashi Kubota, Anne D Donaldson
Publikováno v:
PLoS Genetics, Vol 14, Iss 11, p e1007783 (2018)
Elg1, the major subunit of a Replication Factor C-like complex, is critical to ensure genomic stability during DNA replication, and is implicated in controlling chromatin structure. We investigated the consequences of Elg1 loss for the dynamics of ch
Externí odkaz:
https://doaj.org/article/805b6ff4d47843c1a24934e1d0a45485
Autor:
Miklos Halmai, Orsolya Frittmann, Zoltan Szabo, Andreea Daraba, Vamsi K Gali, Eva Balint, Ildiko Unk
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161307 (2016)
Proliferating cell nuclear antigen (PCNA) plays a key role in many cellular processes and due to that it interacts with a plethora of proteins. The main interacting surfaces of Saccharomyces cerevisiae PCNA have been mapped to the interdomain connect
Externí odkaz:
https://doaj.org/article/38b945b6a0b74c078930662eaf0c279d
Publikováno v:
PLoS Biology, Vol 12, Iss 1, p e1001771 (2014)
DNA damages hinder the advance of replication forks because of the inability of the replicative polymerases to synthesize across most DNA lesions. Because stalled replication forks are prone to undergo DNA breakage and recombination that can lead to
Externí odkaz:
https://doaj.org/article/d641bd02ec82485cb7d6de746fce31c2
Autor:
Robert Toth, Miklos Halmai, Ildiko Unk, Eva Balint, Zsuzsanna Gyorfy, Orsolya Frittmann, Vamsi K Gali
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
DNA damages that hinder the movement of the replication complex can ultimately lead to cell death. To avoid that, cells possess several DNA damage bypass mechanisms. The Rad18 ubiquitin ligase controls error-free and mutagenic pathways that help the
Publikováno v:
Cell Reports
Cell Reports, Vol 16, Iss 3, Pp 684-695 (2016)
Cell Reports, Vol 16, Iss 3, Pp 684-695 (2016)
Summary Loss of the genome maintenance factor Elg1 causes serious genome instability that leads to cancer, but the underlying mechanism is unknown. Elg1 forms the major subunit of a replication factor C-like complex, Elg1-RLC, which unloads the ring-
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Polymerase eta (Polη) is a low fidelity translesion synthesis DNA polymerase that rescues damage-stalled replication by inserting deoxy-ribonucleotides opposite DNA damage sites resulting in error-free or mutagenic damage bypass. In this study we id
Publikováno v:
PLoS Biology, Vol 12, Iss 1, p e1001771 (2014)
PLoS Biology
PLoS Biology
After DNA damage, Def1 triggers degradation of the catalytic subunit of the replicative DNA polymerase at stalled replication forks, allowing special polymerases to take over DNA synthesis.
DNA damages hinder the advance of replication forks bec
DNA damages hinder the advance of replication forks bec
Autor:
Andrea Daraba, Ildiko Unk, Miklós Halmai, Orsolya Frittmann, Vamsi K. Gali, Eva Balint, Zoltán Szabó
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0161307 (2016)
PLoS ONE, Vol 11, Iss 8, p e0161307 (2016)
Proliferating cell nuclear antigen (PCNA) plays a key role in many cellular processes and due to that it interacts with a plethora of proteins. The main interacting surfaces of Saccharomyces cerevisiae PCNA have been mapped to the interdomain connect