Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96.

Autor: Mahran R; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500 Turku, Finland., Kapp JN; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Valtonen S; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500 Turku, Finland., Champagne A; NCI RAS Initiative, Frederick National Laboratory for Cancer Research, 8560 Progress Drive, Frederick, Maryland 21702, United States., Ning J; KYinno Biotechnology Co., Ltd., Yizhuang Biomedical Park, No. 88 Kechuang Six Street, BDA, Beijing 101111, China., Gillette W; NCI RAS Initiative, Frederick National Laboratory for Cancer Research, 8560 Progress Drive, Frederick, Maryland 21702, United States., Stephen AG; NCI RAS Initiative, Frederick National Laboratory for Cancer Research, 8560 Progress Drive, Frederick, Maryland 21702, United States., Hao F; KYinno Biotechnology Co., Ltd., Yizhuang Biomedical Park, No. 88 Kechuang Six Street, BDA, Beijing 101111, China., Plückthun A; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Härmä H; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500 Turku, Finland., Pantsar T; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonrinne 3, 70210 Kuopio, Finland., Kopra K; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500 Turku, Finland.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2024 Oct 18; Vol. 19 (10), pp. 2152-2164. Date of Electronic Publication: 2024 Sep 16.

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Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence.

Autor: Kopra K; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500, Turku, Finland., Hassan N; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500, Turku, Finland., Vuorinen E; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500, Turku, Finland., Valtonen S; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500, Turku, Finland., Mahran R; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500, Turku, Finland., Habib H; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500, Turku, Finland.; Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland., Jalkanen P; Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland., Susi P; Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland., Hytönen V; Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Hankaniemi M; Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Ylä-Herttuala S; A.I.Virtanen Institute, University of Eastern Finland and Gene Therapy Unit, Kuopio University Hospital, 70210, Kuopio, Finland., Kakkola L; Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland., Peurla M; Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland., Härmä H; Department of Chemistry, University of Turku, Henrikinkatu 2, 20500, Turku, Finland. harri.harma@utu.fi.

Publikováno v: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2022 Jun; Vol. 414 (15), pp. 4509-4518. Date of Electronic Publication: 2022 May 17.

Protease Substrate-Independent Universal Assay for Monitoring Digestion of Native Unmodified Proteins.

Autor: Vuorinen E; Department of Chemistry, Chemistry of Drug Development, University of Turku, Vatselankatu 2, 20500 Turku, Finland., Valtonen S; Department of Chemistry, Chemistry of Drug Development, University of Turku, Vatselankatu 2, 20500 Turku, Finland., Hassan N; Department of Chemistry, Chemistry of Drug Development, University of Turku, Vatselankatu 2, 20500 Turku, Finland., Mahran R; Department of Chemistry, Chemistry of Drug Development, University of Turku, Vatselankatu 2, 20500 Turku, Finland., Habib H; Department of Chemistry, Chemistry of Drug Development, University of Turku, Vatselankatu 2, 20500 Turku, Finland.; Department of Virology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland., Malakoutikhah M; Department of Chemistry, Chemistry of Drug Development, University of Turku, Vatselankatu 2, 20500 Turku, Finland., Kopra K; Department of Chemistry, Chemistry of Drug Development, University of Turku, Vatselankatu 2, 20500 Turku, Finland., Härmä H; Department of Chemistry, Chemistry of Drug Development, University of Turku, Vatselankatu 2, 20500 Turku, Finland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 14; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 14.

Sensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studies.

Autor: Valtonen S; Department of Chemistry, University of Turku, Turku, Finland., Vuorinen E; Department of Chemistry, University of Turku, Turku, Finland., Eskonen V; Department of Chemistry, University of Turku, Turku, Finland., Malakoutikhah M; Department of Chemistry, University of Turku, Turku, Finland., Kopra K; Department of Chemistry, University of Turku, Turku, Finland., Härmä H; Department of Chemistry, University of Turku, Turku, Finland.

Publikováno v: MAbs [MAbs] 2021 Jan-Dec; Vol. 13 (1), pp. 1955810.