Bioactive Cembrane Derivatives from the Indian Ocean Soft Coral, Sinularia kavarattiensis

Autor: Katja-Emilia Lillsunde, Carmen Festa, Harshada Adel, Simona De Marino, Valter Lombardi, Supriya Tilvi, Dorota A. Nawrot, Angela Zampella, Lisette D'Souza, Maria Valeria D'Auria, Päivi Tammela

Publikováno v: Marine Drugs, Vol 12, Iss 7, Pp 4045-4068 (2014)

Marine organisms and their metabolites represent a unique source of potential pharmaceutical substances. In this study, we examined marine-derived substances for their bioactive properties in a cell-based Chikungunya virus (CHIKV) replicon model and

Externí odkaz: https://doaj.org/article/5415f3c23c284af78bc25e87baa5fbee

Immunocytochemical Characterization of Alzheimer’s Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine

Autor: Ivan Carrera, Ignacio Etcheverria, Yi Li, Lucia Fernandez-Novoa, Valter Lombardi, Carmen Vigo, Hector H. Palacios, Valery V. Benberin, Ramon Cacabelos, Gjumrakch Aliev

Publikováno v: Central Asian Journal of Global Health, Vol 2, Iss 0 (2014)

Introduction: APP/PS1 double-transgenic mouse models of Alzheimer’s disease (AD), which overexpress mutated forms of the gene for the human amyloid precursor protein (APP) and presenilin 1 (PS1), have provided robust neuropathological hallmarks of

Externí odkaz: https://doaj.org/article/6c6c69decdef4ff79593bb4f208d3bc1

Vaccine Development to Treat Alzheimer’s Disease Neuropathology in APP/PS1 Transgenic Mice

Autor: Iván Carrera, Ignacio Etcheverría, Lucía Fernández-Novoa, Valter Lombardi, Ramón Cacabelos, Carmen Vigo

Publikováno v: International Journal of Alzheimer's Disease, Vol 2012 (2012)

A novel vaccine addressing the major hallmarks of Alzheimer’s disease (AD), senile plaque-like deposits of amyloid beta-protein (Aβ), neurofibrillary tangle-like structures, and glial proinflammatory cytokines, has been developed. The present vacc

Externí odkaz: https://doaj.org/article/95ae08a2834e4009b905bf836a372a81

The Search for Biomarine-derived Compounds with Immunomodulatory Activity

Autor: Lola Corzo, Ramón Cacabelos, Iván Carrera, Valter Lombardi

Publikováno v: Journal of Exploratory Research in Pharmacology. 3:30-41

Many clinical conditions exist in which it is desirable to stimulate or suppress the immune system, and many different drugs are able to do this. It is also well known that nutrition may affect human health and immune responses. Nutritional factors a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a03446bc263d0ea7116a60c5902ae18
https://doi.org/10.14218/jerp.2018.00006

Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea

Autor: Supriya Tilvi, Esra Imamoglu, Johannes Hattara, Gamze Turan, Sofia Montalvão, Prabha Devi, Päivi Tammela, Zeliha Demirel, Meltem Conk Dalay, Merja Perälä, Vesa Hongisto, Valter Lombardi

Publikováno v: Montalvao, S I G H M, Demirel, Z, Devi, P, Lombardi, V, Hongisto, V, Perälä, M, Hattara, J, Imamoglu, E, Tilvi, S S, Turan, G, Dalay, M C & Tammela, P S M 2016, ' Large-scale bioprospecting of cyanobacteria, micro-and macroalgae from the Aegean Sea ', New Biotechnology, vol. 33, no. 3, pp. 399-406 . https://doi.org/10.1016/j.nbt.2016.02.002

Marine organisms constitute approximately one-half of the total global biodiversity, being rich reservoirs of structurally diverse biofunctional components. The potential of cyanobacteria, micro- and macroalgae as sources of antimicrobial, antitumora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6779abcc29084d153ad7475f67d68936
https://cris.vtt.fi/en/publications/b6c8b62e-7e18-4382-ae04-ce120af4e5bf