Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Valter D, Longo"'
Autor:
Sebastian Brandhorst, Morgan E. Levine, Min Wei, Mahshid Shelehchi, Todd E. Morgan, Krishna S. Nayak, Tanya Dorff, Kurt Hong, Eileen M. Crimmins, Pinchas Cohen, Valter D. Longo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we perform
Externí odkaz:
https://doaj.org/article/07535cae9755447cbf16d32138fdada8
Autor:
Sebastian Brandhorst, Valter D. Longo
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
In recent decades, the study of biological aging has evolved from simplistic theories like the free radical theory to more complex and nuanced perspectives. In particular, the identification of evolutionary conserved genes and signaling pathways that
Externí odkaz:
https://doaj.org/article/494143a2576d48be872de62861075a5a
Autor:
Zoltan Kender, Ekaterina von Rauchhaupt, Daniel Schwarz, Dimitrios Tsilingiris, Lukas Schimpfle, Hannelore Bartl, Valter D. Longo, Martin Bendszus, Stefan Kopf, Stephan Herzig, Sabine Heiland, Julia Szendroedi, Alba Sulaj
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Background and aimCurrent strategies for preventing diabetic sensorimotor polyneuropathy (DSPN) are limited mainly to glucose control but rapid decrease of glycemia can lead to acute onset or worsening of DSPN. The aim of this study was to examine th
Externí odkaz:
https://doaj.org/article/0767b283a2a54e8689fa7efb9a6f8334
Autor:
Alberto Diaz-Ruiz, Tyler Rhinesmith, Laura C. D. Pomatto-Watson, Nathan L. Price, Farzin Eshaghi, Margaux R. Ehrlich, Jacqueline M. Moats, Melissa Carpenter, Annamaria Rudderow, Sebastian Brandhorst, Julie A. Mattison, Miguel A. Aon, Michel Bernier, Valter D. Longo, Rafael de Cabo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Understanding the contribution of diet composition, calories and length of fasting in health maintenance is still challenging. Here the authors compare the effects of cycles of intermittent very low calorie intake achieved with a plant-based fasting
Externí odkaz:
https://doaj.org/article/1dc4b15f57244a44ad6c5f3abdb932b9
Autor:
Laura C. D. Pomatto-Watson, Monica Bodogai, Oye Bosompra, Jonathan Kato, Sarah Wong, Melissa Carpenter, Eleonora Duregon, Dolly Chowdhury, Priya Krishna, Sandy Ng, Emeline Ragonnaud, Roberto Salgado, Paula Gonzalez Ericsson, Alberto Diaz-Ruiz, Michel Bernier, Nathan L. Price, Arya Biragyn, Valter D. Longo, Rafael de Cabo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Caloric restriction (CR) has been shown as an effective intervention to reduce tumorigenesis, but alternative less stringent dietary interventions have also been considered. Here, the authors show that in a murine model of breast cancer CR has a larg
Externí odkaz:
https://doaj.org/article/23bdba50f5d9416ba338e8343d216d8e
Autor:
Stefanie de Groot, Rieneke T. Lugtenberg, Danielle Cohen, Marij J. P. Welters, Ilina Ehsan, Maaike P. G. Vreeswijk, Vincent T. H. B. M. Smit, Hiltje de Graaf, Joan B. Heijns, Johanneke E. A. Portielje, Agnes J. van de Wouw, Alex L. T. Imholz, Lonneke W. Kessels, Suzan Vrijaldenhoven, Arnold Baars, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Hein Putter, Jacobus J. M. van der Hoeven, Johan W. R. Nortier, Valter D. Longo, Hanno Pijl, Judith R. Kroep, Dutch Breast Cancer Research Group (BOOG)
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Preclinical evidence suggests that a fasting mimicking diet (FMD) can make cancer cells more vulnerable to chemotherapy, while protecting normal cells. In this randomized phase II clinical trial of 131 patients with HER2 negative early stage breast c
Externí odkaz:
https://doaj.org/article/ece7e746301b495eb80ac3a814697099
Autor:
Elske L. van den Burg, Marjolein P. Schoonakker, Petra G. van Peet, M. Elske. van den Akker-van Marle, Ko Willems van Dijk, Valter D. Longo, Hildo J. Lamb, Mattijs E. Numans, Hanno Pijl
Publikováno v:
BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Caloric restriction is an effective way to treat Type 2 diabetes (T2D). However, chronic and severe restriction of food intake is difficult to sustain and is known to promote slower metabolism. Intermittent and frequent fasting ca
Externí odkaz:
https://doaj.org/article/c72b72812cfe4abe817ff623f3de6f5a
Autor:
Maira Di Tano, Franca Raucci, Claudio Vernieri, Irene Caffa, Roberta Buono, Maura Fanti, Sebastian Brandhorst, Giuseppe Curigliano, Alessio Nencioni, Filippo de Braud, Valter D. Longo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Fasting diets are emerging as an approach to delay tumor progression and improve cancer therapies. Here, the authors show that the combination of fasting-mimicking diet with vitamin C decreases tumor development and increases chemotherapy efficacy in
Externí odkaz:
https://doaj.org/article/92142cabaa704417840b9b0bfd484ff0
Autor:
Mario G. Mirisola, Valter D. Longo
Publikováno v:
Cells, Vol 11, Iss 10, p 1714 (2022)
S. cerevisiae plays a pivotal role as a model system in understanding the biochemistry and molecular biology of mammals including humans. A considerable portion of our knowledge on the genes and pathways involved in cellular growth, resistance to tox
Externí odkaz:
https://doaj.org/article/ba495f2d6d374f04b9070cd9d51f58a9
Publikováno v:
Trends in Cancer. 9:212-222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0161a72d3647a0ee85695ca59d97c87
https://doi.org/10.1016/j.trecan.2022.12.006
https://doi.org/10.1016/j.trecan.2022.12.006