Non-enzymatic properties of Proteus mirabilis urease subunits

Autor: Augusto F. Uberti, Leonardo L. Fruttero, Valquiria Broll, Fernanda Cortez Lopes, Matheus V. Coste Grahl, Célia R. Carlini, Rodrigo Ligabue-Braun, Natalia R. Moyetta, Anne H.S. Martinelli, Diogo Ribeiro Demartini, Ana Paula A. Perin

Publikováno v: Process Biochemistry. 110:263-274

Ureases are moonlighting proteins displaying non-catalytic properties, including platelet activation, antifungal and entomotoxic effects. The structure-activity mapping of these properties is poorly developed. Proteus mirabilis urease (PMU) consists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aab714cc783435e63761b315bc44506b
https://doi.org/10.1016/j.procbio.2021.08.023

Proteus mirabilis Urease: Unsuspected Non-Enzymatic Properties Relevant to Pathogenicity

Autor: Augusto F. Uberti, Matheus V. Coste Grahl, Paula Bacaicoa-Caruso, Evelin F Meirelles, Célia R. Carlini, Valquiria Broll

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 7205, p 7205 (2021)

Infection by Proteus mirabilis causes urinary stones and catheter incrustation due to ammonia formed by urease (PMU), one of its virulence factors. Non-enzymatic properties, such as pro-inflammatory and neurotoxic activities, were previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cda9cb608337c793e694bb8384c4c0
http://europepmc.org/articles/PMC8268090

List of contributors

Autor: Liliana Aguilar-Marcelino, Mushtaq Ahmed, Laith Khalil Tawfeeq Al-Ani, Anshu Alok, S. Aravindan, Mathew S. Baite, Raina Bajpai, Despoina Beris, Hareram Birla, Didier Bogusz, Valquiria Broll, Lorena Carro, Antony Champion, Wenfeng Chen, Wenxin Chen, Juliana Oliveira de Carvalho, Filippe Elias de Freitas Soares, Nasser Delangiz, Nathalie Diagne, Hagera Dilnashin, Pape Ibrahima Djighaly, Éverton Kort Kamp Fernandes, Claudine Franche, Edson Luiz Furtado, null Geetika, Mansour Ghorbanpour, Patrícia Silva Gôlo, Olga Gómez-Rodríguez, Oscar González-López, A.B.M. Gulzar, Chen Guo, Vipin Hallan, Trinh Xuan Hoat, Valérie Hocher, null Ikbal, Siva Satya Mohan Jampala, P. Jeyakumar, Yogeshvari K. Jhala, Gurdeep Kaur, Jaspreet Kaur, Solmaz Kazemalilou, U. Keerthana, Chetan Keswani, Ekta Khare, Surender Kumar, Indu Kumari, Nidhi Kumari, Reenu Kumari, Behnam Asgari Lajayer, Erik Limpens, Fernanda Cortez Lopes, María Eugenia López-Arellano, Rita Mahapatra, Anudeep B. Malannavar, Anne Helene Souza Martinelli, P.B. Mazumder, Pedro Mendoza-de-Gives, Esther Menéndez, Aeshah Mhana Mohammed, Ewa B. Moliszewska, Małgorzata Nabrdalik, Mariama Ngom, Deepak G. Panpatte, Nishat Passricha, Jai Singh Patel, Zalak M. Patel, Kishor Sureshbhai Patil, Shanshan Peng, Céline Pesce, S.R. Prabhukarthikeyan, S. Raghu, Md. Mahtab Rashid, P.C. Rath, Waseem Raza, David Emmanuel Reyes-Guerrero, David Ruano-Rosa, Davood Saghafi, Shabnam K. Saifi, Richa Salwan, Yimin Shang, Anu Sharma, Shikha Sharma, Vivek Sharma, Qirong Shen, Virendra K Sikka, H.B. Singh, S.P. Singh, Bijoya Singha, S. Srividhya, R. Surendranath, Sergio Svistoonoff, Basavaraj Teli, Louis S. Tisa, Siddharth Tiwari, Narendra Tuteja, Swati Tyagi, Jelle van Creij, Udaya Kumar Vandana, Mohammad Behrouzi Varjovi, Nikon Vassilakos, Edgar Villar-Luna, Rajababu V. Vyas, Peng Wang, Manoj K. Yadav, Sudheer Kumar Yadav, Junjie Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ce808de03a3cbf8cc36139565f78427
https://doi.org/10.1016/b978-0-12-818469-1.00038-9

Structural analysis of the interaction between Jaburetox, an intrinsically disordered protein, and membrane models

Autor: Fernanda Cortez Lopes, Edoardo Salladini, Leonardo L. Fruttero, Anne H.S. Martinelli, Barbara Zambelli, Olena Dobrovolska, Stefano Ciurli, Valquiria Broll, Célia R. Carlini

Publikováno v: Colloids and Surfaces B: Biointerfaces. 159:849-860

Jack bean urease is entomotoxic to insects with cathepsin-like digestive enzymes, and its toxicity is mainly caused by a polypeptide called Jaburetox (Jbtx), released by cathepsin-dependent hydrolysis of the enzyme. Jbtx is intrinsically disordered i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c8bba0b6fdbda22fd3e230524abc9a
https://doi.org/10.1016/j.colsurfb.2017.08.053

Jaburetox affects gene expression and enzyme activities in Rhodnius prolixus, a Chagas’ disease vector

Autor: Monique Siebra Krug, Valquiria Broll, Leonardo L. Fruttero, Rafael Real-Guerra, Natalia R. Moyetta, Matheus V. Coste Grahl, Célia R. Carlini, Fernanda Stanisçuaski

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Jaburetox, a recombinant peptide of ∼11 kDa derived from one of the Canavalia ensiformis (Jack Bean) urease isoforms, is toxic and lethal to insects belonging to different orders when administered orally or via injection. Previous findings indicate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3661df03bc2377a775b3cd0853f1d553
https://doi.org/10.1016/j.actatropica.2017.01.009