Výsledky vyhledávání - "Valnice J Peres"

Akademický článek

Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum

Autor: María B Cassera, Emilio F Merino, Valnice J Peres, Emilia A Kimura, Gerhard Wunderlich, Alejandro M Katzin

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 102, Iss 3, Pp 377-384 (2007)

In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway. Fosmidomycin is a specific inhibitor

Externí odkaz: https://doaj.org/article/b7f069bcfde046a0946a99f0f209621b

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Metabolic oligosaccharide engineering of Plasmodium falciparum intraerythrocytic stages allows direct glycolipid analysis by mass spectrometry

Autor: Tamara Piñero, Valnice J. Peres, Alicia S. Couto, Alejandro M. Katzin

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

A recent addition to the arsenal of tools for glycome analysis is the use of metabolic labels that allow covalent tagging of glycans with imaging probes. In this work we show that N-azidoglucosamine was successfully incorporated into glycolipidic str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c6c8ccf3cc3f0599203d4c8e59a789
https://doi.org/10.1016/j.molbiopara.2011.12.008

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Plasmodium falciparum biosynthesizes sulfoglycosphingolipids

Autor: Alicia S. Couto, Vilma G. Duschak, Alejandro M. Katzin, Rosa Erra-Balsells, Valnice J. Peres, Hiroshi Nonami, Malena Landoni

Publikováno v: Molecular and Biochemical Parasitology. 154:22-29

Sulfated glycosphingolipids are present on the surface of a variety of cells. They are active participants in adhesion processes in many systems and appear to be involved in the regulation of cell proliferation, differentiation and other developmenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afdd5caa64b376c530ca505f442527b
https://doi.org/10.1016/j.molbiopara.2007.03.014

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Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum

Autor: Emilio F. Merino, Maria B. Cassera, Emilia A. Kimura, Gerhard Wunderlich, Alejandro M. Katzin, Valnice J. Peres

Publikováno v: Memórias do Instituto Oswaldo Cruz, Volume: 102, Issue: 3, Pages: 377-384, Published: JUN 2007
Memórias do Instituto Oswaldo Cruz., Vol 102, Iss 3, Pp 377-384 (2007)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf8fc56ba32b962603c3e2af38bef65
https://doi.org/10.1590/s0074-02762007000300019

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In vitro antimalarial activity of different inhibitors of the plasmodial isoprenoid synthesis pathway

Autor: Marcia F. da Silva, Alexandre Y. Saito, Alejandro M. Katzin, Antonio Carlos Oliveira, Valnice J. Peres

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Previous studies have shown that fosmidomycin, risedronate, and nerolidol exert antimalarial activity in vitro . We included squalestatin, an inhibitor of the isoprenoid metabolism in Erwinia uredovora , and found that combinations of compounds which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4172ca1f713e1a2735be91fb6a60f1ae

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Protein dolichylation inPlasmodium falciparum

Autor: Emilia A. Kimura, Alejandro M. Katzin, Valnice J. Peres, Fabio Luiz D’Alexandri

Publikováno v: FEBS Letters. 580:6343-6348

We performed reverse-phase thin-layer chromatography and reverse-phase high-performance liquid chromatography (RP-HPLC) analysis of polyisoprenoids released by sulfonium-salt cleavage with methyl iodide from Plasmodium falciparum proteins labeled wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25018d8af8c2caf8e32e452fa8f2e34
https://doi.org/10.1016/j.febslet.2006.10.042

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Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum

Autor: Fabio C. Gozzo, Fernando A. Genta, Marcos N. Eberlin, Valnice J. Peres, Alejandro M. Katzin, Emilia A. Kimura, Fabio Luiz D’Alexandri, Renata Tonhosolo, Gerhard Wunderlich

Publikováno v: Biochemical Journal. 392:117-126

Isoprenoids play important roles in all living organisms as components of structural cholesterol, steroid hormones in mammals, carotenoids in plants, and ubiquinones. Significant differences occur in the length of the isoprenic side chains of ubiquin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dface21e45f8454ba71388f019ce6c7
https://doi.org/10.1042/bj20050441

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The Methylerythritol Phosphate Pathway Is Functionally Active in All Intraerythrocytic Stages of Plasmodium falciparum

Autor: Alejandro M. Katzin, Jochen Wiesner, Emilio F. Merino, Marcos N. Eberlin, Fabio C. Gozzo, Igor C. Almeida, Hassan Jomaa, Fabio Luiz D’Alexandri, Gerhard Wunderlich, Emilia A. Kimura, Maria B. Cassera, Valnice J. Peres, Hernando A. del Portillo

Publikováno v: Journal of Biological Chemistry. 279:51749-51759

Two genes encoding the enzymes 1-deoxy-D-xylulose-5-phosphate synthase and 1-deoxy-D-xylulose-5-phosphate reductoisomerase have been recently identified, suggesting that isoprenoid biosynthesis in Plasmodium falciparum depends on the methylerythritol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ca6bf8d3af6a445fed268088b02272
https://doi.org/10.1074/jbc.m408360200

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Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: presence of dolichols of 11 and 12 isoprene units

Autor: Alejandro M. Katzin, María Laura Uhrig, Alicia S. Couto, Emilia A. Kimura, Valnice J. Peres

Publikováno v: Biochemical Journal. 341:629-637

N-glycosylation of proteins is required for the intra-erythrocytic schizogony of Plasmodium falciparum. In eukaryotic cells, this process involves the transfer of oligosaccharides from a dolichyl pyrophosphate derivative to asparagine residues. We ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dac22bbd7fa4e20ecdf81ba6b132c6a6
https://doi.org/10.1042/bj3410629

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Linked Glycoproteins Are Related to Schizogony of the Intraerythrocytic Stage in

Autor: Alicia S. Couto, Olga L. Casal, Emilia A. Kimura, Alejandro M. Katzin, Valnice J. Peres

Publikováno v: Journal of Biological Chemistry. 271:14452-14461

Although the existence of O-linked oligosaccharide residues in glycoproteins of Plasmodium falciparum has been shown, the existence of N-linked glycoproteins is still a matter of controversy and skepticism. This report demonstrates the unequivocal pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b60a6d5d25229a419a8fb8abb0b17dd
https://doi.org/10.1074/jbc.271.24.14452

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