Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Valmik Desai"'
Autor:
Ruifeng Liu, Mohamed Diwan M. AbdulHameed, Zhen Xu, Benjamin Clancy, Valmik Desai, Anders Wallqvist
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Toxidromes constitute patterns of symptoms and signs caused by specific toxic effects that guide emergency treatments. Computational identification of chemicals that cause different toxidromes allows us to rapidly screen novel compounds and compound
Externí odkaz:
https://doaj.org/article/20aae584bc9546268294df996332f71a
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Gene-set analysis is commonly used to identify trends in gene expression when cells, tissues, organs, or organisms are subjected to conditions that differ from those within the normal physiological range. However, tools for gene-set analysis to asses
Externí odkaz:
https://doaj.org/article/89cb6543229c49a1b4a0a59c3a21c772
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
In drug development, early assessments of pharmacokinetic and toxic properties are important stepping stones to avoid costly and unnecessary failures. Considerable progress has recently been made in the development of computer-based (in silico) model
Externí odkaz:
https://doaj.org/article/6e4b8bcc776543b88b6dacc592001628
Autor:
Sidhartha Chaudhury, Gregory D Gromowski, Daniel R Ripoll, Ilja V Khavrutskii, Valmik Desai, Anders Wallqvist
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005395 (2017)
BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a centra
Externí odkaz:
https://doaj.org/article/fa9414519755456db726302c20606355
Autor:
Jun Hang, Nela Zavaljevski, Yu Yang, Valmik Desai, Richard C Ruck, Louis R Macareo, Richard G Jarman, Jaques Reifman, Robert A Kuschner, Paul B Keiser
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188461 (2017)
Certain occupational and geographical exposures have been associated with an increased risk of lung disease. As a baseline for future studies, we sought to characterize the upper respiratory microbiomes of healthy military personnel in a garrison env
Externí odkaz:
https://doaj.org/article/1a700327af164e8b8837c43c980e2bb8
Autor:
Kamal Kumar, Valmik Desai, Li Cheng, Maxim Khitrov, Deepak Grover, Ravi Vijaya Satya, Chenggang Yu, Nela Zavaljevski, Jaques Reifman
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17469 (2011)
BACKGROUND: The annotation of genomes from next-generation sequencing platforms needs to be rapid, high-throughput, and fully integrated and automated. Although a few Web-based annotation services have recently become available, they may not be the b
Externí odkaz:
https://doaj.org/article/56972f0851a341dca351736956e50d08
Autor:
Michael S Lee, Rajkumar Bondugula, Valmik Desai, Nela Zavaljevski, In-Chul Yeh, Anders Wallqvist, Jaques Reifman
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6254 (2009)
BACKGROUND:Protein structures are critical for understanding the mechanisms of biological systems and, subsequently, for drug and vaccine design. Unfortunately, protein sequence data exceed structural data by a factor of more than 200 to 1. This gap
Externí odkaz:
https://doaj.org/article/14ce1c20b9514daea174d01cf84ee929
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Gene-set analysis is commonly used to identify trends in gene expression when cells, tissues, organs, or organisms are subjected to conditions that differ from those within the normal physiological range. However, tools for gene-set analysis to asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396fc4b9695b7cfc88ad008d4305712c
http://europepmc.org/articles/PMC7900624
http://europepmc.org/articles/PMC7900624
Autor:
Zhen Xu, Patric Schyman, Ruifeng Liu, Anders Wallqvist, Valmik Desai, Mohamed Diwan M. AbdulHameed, Daniel Sachs
Publikováno v:
Computational Toxicology. 18:100162
Identifying the ability of a chemical to interact with toxicity targets, such as proteins in an adverse outcome pathway, is an essential step in drug discovery and risk assessment. Computational approaches to screen for chemical-toxicity target inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a17931cfc50ac276e8abf432cde5407
https://doi.org/10.1016/j.comtox.2021.100162
https://doi.org/10.1016/j.comtox.2021.100162
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 8 (2017)
Frontiers in Pharmacology, Vol 8 (2017)
In drug development, early assessments of pharmacokinetic and toxic properties are important stepping stones to avoid costly and unnecessary failures. Considerable progress has recently been made in the development of computer-based (in silico) model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faee1cbbfc361e18fe0353bd55553665
https://pubmed.ncbi.nlm.nih.gov/29255418
https://pubmed.ncbi.nlm.nih.gov/29255418