Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

Autor: Jennifer H. Mahaffey, Maria A. Cavasin, T. Brett Reece, Ying H. Lin, Henk Granzier, Charles A. Dinarello, Mark Y. Jeong, Chandrasekhar Saripalli, Kimberly M. Demos-Davies, Sara A. Wennersten, Valmen Monzani, Paolo Mascagni, Timothy A. McKinsey, Amrut V. Ambardekar

Publikováno v: Science Translational Medicine, 10, 427
Science Translational Medicine, 10

There are no approved drugs for the treatment of heart failure with preserved ejection fraction (HFpEF), which is characterized by left ventricular (LV) diastolic dysfunction. We demonstrate that ITF2357 (givinostat), a clinical-stage inhibitor of hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a7d2e635f91c8c6743f8e0bfe00f0c
https://pubmed.ncbi.nlm.nih.gov/29437146

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

Autor: Nicolai Juul Birkbak, Morten Lundh, Christopher T. Workman, Steven Paraskevas, Susanne Mandrup, Søren Fisker Schmidt, Reid Aikin, Lykke Blaabjerg, Lars Groth Grunnet, Daniel Noesgaard, Dan Ploug Christensen, Paolo Mascagni, Gianluca Fossati, Conny Gysemans, Chantal Mathieu, Thomas Mandrup-Poulsen, Nils Billestrup, Mattias S. Dahllöf, Valmen Monzani, Lorenzo Piemonti, Charles A. Dinarello

Publikováno v: Christensen, D P, Gysemans, C, Lundh, M, Dahllöf, M S, Noesgaard, D, Schmidt, S F, Mandrup, S, Birkbak, N, Workman, C, Piemonti, L, Blaabjerg, L, Monzani, V, Fossati, G, Mascagni, P, Paraskevas, S, Aikin, R A, Billestrup, N, Grunnet, L G, Dinarello, C A, Mathieu, C & Mandrup-Poulsen, T 2014, ' Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection ', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 3, pp. 1055-9 . https://doi.org/10.1073/pnas.1320850111
Proceedings of the National Academy of Sciences USA, 111, 1055-9
Proceedings of the National Academy of Sciences USA, 111, 3, pp. 1055-9

Type 1 diabetes is due to destruction of pancreatic β-cells. Lysine deacetylase inhibitors (KDACi) protect β-cells from inflammatory destruction in vitro and are promising immunomodulators. Here we demonstrate that the clinically well-tolerated KDA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e178acbef1a94c9140cc523ffbad3fd
https://hdl.handle.net/20.500.14017/46c8e1ed-c60c-4e1d-9bc2-1e66acc3ab5e

Solvation enthalpies as descriptors of structure--in vitro percutaneous permeation relationship of benzoxazinones regioisomers

Autor: Francesco Cilurzo, Giorgio Bertolini, Andrea Zaliani, Antonella Casiraghi, Luisa Montanari, M. Valmen Monzani, Paola Minghetti

Publikováno v: Farmaco (Societa chimica italiana : 1989). 55(8)

The aim of this work was to correlate the in vitro human skin permeability, expressed as the permeability coefficient ( K p ), and some physicochemical parameters of a new series of benzoxazinones. The in vitro human skin permeability of 14 substance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4595a799d6aefd1d4412c9c6fd5c41e3
https://pubmed.ncbi.nlm.nih.gov/11132734

T.P.2 Givinostat improves histological and functional parameters in mdx mice dose and concentration dependently

Autor: Paolo Mascagni, Silvia Consalvi, Valmen Monzani, F. Del Bene, Pier Lorenzo Puri, Massimiliano Germani, Paolo Bettica, Valentina Saccone, Chiara Mozzetta

Publikováno v: Neuromuscular Disorders. 22:847

Inhibition of Histone Deacetylases (HDAC) has beneficial effects in mouse models of muscular dystrophies indicating that HDACs are a potential pharmacological target for Duchenne Muscular Dystrophy (DMD). We have studied the effects of Givinostat, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1443e02e73a6061622f90c95a8e7ee58
https://doi.org/10.1016/j.nmd.2012.06.148

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.