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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.

Autor: Bonagas N; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Gustafsson NMS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Henriksson M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Marttila P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Gustafsson R; Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden., Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Borhade S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Green AC; Weston Park Cancer Centre, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK., Vallin KSA; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Sarno A; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Svensson R; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy, Uppsala University, Uppsala, Sweden., Göktürk C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Pham T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Loseva O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Cookson V; Weston Park Cancer Centre, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK., Kiweler N; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg., Sandberg L; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Rasti A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Unterlass JE; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Haraldsson M; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden., Andersson Y; Drug Discovery and Development Platform, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Solna, Sweden., Scaletti ER; Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Bengtsson C; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Paulin CBJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Sanjiv K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Abdurakhmanov E; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Pudelko L; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Kunz B; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Desroses M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Iliev P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Färnegårdh K; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Krämer A; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany., Garg N; Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Michel M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Häggblad S; Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Jarvius M; Department of Medical Sciences, Division of Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden., Kalderén C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Jensen AB; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Almlöf I; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Karsten S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Zhang SM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Häggblad M; Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Eriksson A; Karolinska High Throughput Centre, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Liu J; Karolinska High Throughput Centre, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Glinghammar B; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden., Nekhotiaeva N; Karolinska High Throughput Centre, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Klingegård F; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden., Koolmeister T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Martens U; Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden., Llona-Minguez S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Moulson R; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Nordström H; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Parrow V; Department of Medical Sciences, Division of Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden., Dahllund L; Drug Discovery and Development Platform, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Solna, Sweden., Sjöberg B; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden., Vargas IL; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Vo DD; Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Wannberg J; Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany., Krokan HE; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Arvidsson PI; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden., Scobie M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Meiser J; Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg., Stenmark P; Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Berglund UW; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Homan EJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. thomas.helleday@scilifelab.se.; Weston Park Cancer Centre, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK. thomas.helleday@scilifelab.se.

Publikováno v: Nature cancer [Nat Cancer] 2022 Feb; Vol. 3 (2), pp. 156-172. Date of Electronic Publication: 2022 Feb 28.

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.

Autor: Carter M; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden., Jemth AS; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 21 Stockholm, Sweden., Carreras-Puigvert J; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 21 Stockholm, Sweden., Herr P; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 21 Stockholm, Sweden., Martínez Carranza M; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden., Vallin KSA; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 21 Stockholm, Sweden., Throup A; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 21 Stockholm, Sweden., Helleday T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 21 Stockholm, Sweden. Electronic address: thomas.helleday@scilifelab.se., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden. Electronic address: stenmark@dbb.su.se.

Publikováno v: Structure (London, England : 1993) [Structure] 2018 Feb 06; Vol. 26 (2), pp. 295-303.e6.