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Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.

Autor: Monn JA; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. monn@lilly.com, Valli MJ, Massey SM, Hao J, Reinhard MR, Bures MG, Heinz BA, Wang X, Carter JH, Getman BG, Stephenson GA, Herin M, Catlow JT, Swanson S, Johnson BG, McKinzie DL, Henry SS

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2013 Jun 13; Vol. 56 (11), pp. 4442-55. Date of Electronic Publication: 2013 Jun 03.

Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors.

Autor: Monn JA; Neuroscience Research Division, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. monn@lilly.com, Massey SM, Valli MJ, Henry SS, Stephenson GA, Bures M, Hérin M, Catlow J, Giera D, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2007 Jan 25; Vol. 50 (2), pp. 233-40.

Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.

Autor: Monn JA; Discovery Chemistry, Process Research and Development, Neuroscience, and Toxicology Research Divisions, Eli Lilly and Company, Indianapolis, Indiana 46285, USA., Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, Harkness AR, Grutsch JL Jr, Wright RA, Johnson BG, Andis SL, Kingston A, Tomlinson R, Lewis R, Griffey KR, Tizzano JP, Schoepp DD

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1999 Mar 25; Vol. 42 (6), pp. 1027-40.

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties.

Autor: Monn JA; Central Nervous System Division, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. Monn@Lilly.com, Valli MJ, Massey SM, Wright RA, Salhoff CR, Johnson BG, Howe T, Alt CA, Rhodes GA, Robey RL, Griffey KR, Tizzano JP, Kallman MJ, Helton DR, Schoepp DD

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1997 Feb 14; Vol. 40 (4), pp. 528-37.