Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Valle Palomo"'
Autor:
Vanesa Nozal, Paula Fernández-Gómez, Alfonso García-Rubia, Loreto Martínez-González, Eva P. Cuevas, Eva Carro, Valle Palomo, Ana Martínez
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116626- (2024)
Multitarget ligands (MTLs) have emerged as an interesting alternative for addressing complex multifactorial pathologies such as neurodegenerative diseases. However, a common challenge associated with these compounds is often their high molecular weig
Externí odkaz:
https://doaj.org/article/3d33e86fd4984177be6742f62749d3db
Autor:
Eva P. Cuevas, Loreto Martinez-Gonzalez, Clara Gordillo, Carlota Tosat-Bitrián, Carmen Pérez de la Lastra, Amets Sáenz, Carmen Gil, Valle Palomo, Ángeles Martin-Requero, Ana Martinez
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106430- (2024)
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease without a cure to reverse its progression. Its main hallmark is the nuclear protein TDP-43, which undergoes different post-translational modifications leading to a loss of function in
Externí odkaz:
https://doaj.org/article/b4e04e092b5c4a59a6337799371bb688
Autor:
Loreto Martinez-Gonzalez, Eva P. Cuevas, Carlota Tosat-Bitrián, Vanesa Nozal, Carmen Gil, Valle Palomo, Ángeles Martín-Requero, Ana Martinez
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionTDP-43 proteinopathy in Alzheimer’s disease (AD) patients is recently emerging as a relevant pathomolecular event that may have been overlooked. Recent results in immortalized lymphocytes from AD patients have shown not only an increase
Externí odkaz:
https://doaj.org/article/e4f7366995854e60ba83492f730a9c84
Autor:
Paula Fernández-Gómez, Carmen Pérez de la Lastra Aranda, Carlota Tosat-Bitrián, Jesús Alejandro Bueso de Barrio, Sebastián Thompson, Begoña Sot, Gorka Salas, Álvaro Somoza, Ana Espinosa, Milagros Castellanos, Valle Palomo
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
The new and unique possibilities that nanomaterials offer have greatly impacted biomedicine, from the treatment and diagnosis of diseases, to the specific and optimized delivery of therapeutic agents. Technological advances in the synthesis, characte
Externí odkaz:
https://doaj.org/article/06c67bbbca6740168ba6f00b0a9e43ac
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/b6408f15c20c4ca986a8a40aad51b630
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/5c8e7ecdb46d4d869160fdde5830b7f6
Autor:
María Ángela Oliva, Carlota Tosat-Bitrián, Lucía Barrado-Gil, Francesca Bonato, Inmaculada Galindo, Urtzi Garaigorta, Beatriz Álvarez-Bernad, Rebeca París-Ogáyar, Daniel Lucena-Agell, Juan Francisco Giménez-Abián, Isabel García-Dorival, Jesús Urquiza, Pablo Gastaminza, José Fernando Díaz, Valle Palomo, Covadonga Alonso
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3448 (2022)
Microtubule targeting agents (MTAs) have been exploited mainly as anti-cancer drugs because of their impact on cellular division and angiogenesis. Additionally, microtubules (MTs) are key structures for intracellular transport, which is frequently hi
Externí odkaz:
https://doaj.org/article/2671d7e2726042098829308ac7b619d1
Autor:
Eva P. Cuevas, Alberto Rodríguez-Fernández, Valle Palomo, Ana Martínez, Ángeles Martín-Requero
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 385 (2022)
Alzheimer’s disease (AD) is a neurodegenerative disorder for which there is currently no effective treatment. Despite advances in the molecular pathology of the characteristic histopathological markers of the disease (tau protein and β-amyloid), t
Externí odkaz:
https://doaj.org/article/2d5d8c9de43440c8a7fcedb4fb09d9e3
Autor:
Alonso Sánchez-Cruz, Beatriz Villarejo-Zori, Miguel Marchena, Josefa Zaldivar-Díez, Valle Palomo, Carmen Gil, Ignacio Lizasoain, Pedro de la Villa, Ana Martínez, Enrique J. de la Rosa, Catalina Hernández-Sánchez
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-10 (2018)
Abstract Background Retinitis pigmentosa (RP) is a group of hereditary retinal neurodegenerative conditions characterized by primary dysfunction and death of photoreceptor cells, resulting in visual loss and, eventually, blindness. To date, no effect
Externí odkaz:
https://doaj.org/article/1f5166918c664d03a5a2b131421fd7fa
Autor:
Anabel Rico, Garazi Guembelzu, Valle Palomo, Ana Martínez, Ana Aiastui, Leire Casas-Fraile, Andrea Valls, Adolfo López de Munain, Amets Sáenz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7367 (2021)
Limb-girdle muscular dystrophy R1 calpain 3-related (LGMDR1) is an autosomal recessive muscular dystrophy produced by mutations in the CAPN3 gene. It is a rare disease and there is no cure or treatment for the disease while the pathophysiological mec
Externí odkaz:
https://doaj.org/article/f620c792fcf24c9dbeb406f528e23112