Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

Autor: Tran, Thuy-Anh, Shin, Young-Jun, Kramer, Bryan, Choi, Juyi, Zou, Ning, Vallar, Pureza, Martens, Peter, Douglas Boatman, P., Adams, John W., Ramirez, Juan, Shi, Yunqing, Morgan, Michael, Unett, David J., Chang, Steve, Shu, Hsin-Hui, Tung, Shiu-Feng, Semple, Graeme

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 March 2015 25(5):1030-1035

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.

Autor: Thuy-Anh Tran, Kramer, Bryan, Young-Jun Shin, Vallar, Pureza, Boatman, P. Douglas, Ning Zou, Sage, Carleton R., Gharbaoui, Tawfik, Krishnan, Ashwin, Pal, Biman, Shakya, Sagar R., Montalban, Antonio Garrido, Adams, John W., Ramirez, Juan, Behan, Dominic P., Shifrina, Anna, Blackburn, Anthony, Leakakos, Tina, Yunqing Shi, Morgan, Michael

Publikováno v: Journal of Medicinal Chemistry; Feb2017, Vol. 60 Issue 3, p913-927, 15p

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.

Autor: Tran TA; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Kramer B; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shin YJ; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Vallar P; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Boatman PD; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Zou N; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Sage CR; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Gharbaoui T; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Krishnan A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Pal B; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shakya SR; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Garrido Montalban A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Adams JW; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Ramirez J; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Behan DP; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shifrina A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Blackburn A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Leakakos T; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shi Y; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Morgan M; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Sadeque A; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Chen W; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Unett DJ; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Gaidarov I; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Chen X; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Chang S; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Shu HH; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Tung SF; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States., Semple G; Arena Pharmaceuticals , 6154 Nancy Ridge Drive, San Diego, California 92121, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Feb 09; Vol. 60 (3), pp. 913-927. Date of Electronic Publication: 2017 Jan 19.