Výsledky vyhledávání

A systems model of phosphorylation for inflammatory signaling events

Autor: Sadreev I., Chen M., Welsh G., Umezawa Y., Kotov N., Valeyev N.

Publikováno v: SCOPUS-2014-9-10-SID84908192071

© 2014 Sadreev et al. Phosphorylation is a fundamental biochemical reaction that modulates protein activity in cells. While a single phosphorylation event is relatively easy to understand, multisite phosphorylation requires systems approaches for de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3132c239d61d052570345b99e57663b1
https://openrepository.ru/article?id=718369

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Systems biology of cell behavior

Autor: Valeyev N., Bates D., Umezawa Y., Gizatullina A., Kotov N.

Publikováno v: SCOPUS10643745-2010-662-SID84934440870

Systems Biology approaches to drug discovery largely focus on the increasing understanding of intracellular and cellular circuits, by computational representation of a molecular system followed by parameter validation against experimental data. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::08087ee5f86bf755b5c1290d875b18d1
https://openrepository.ru/article?id=48915

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A systems model for immune cell interactions unravels the mechanism of inflammation in human skin

Autor: Valeyev N., Hundhausen C., Umezawa Y., Kotov N., Williams G., Clop A., Ainali C., Ouzounis C., Tsoka S., Nestle F.

Publikováno v: SCOPUS1553734X-2010-6-12-SID78651250747

Inflammation is characterized by altered cytokine levels produced by cell populations in a highly interdependent manner. To elucidate the mechanism of an inflammatory reaction, we have developed a mathematical model for immune cell interactions via t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1d070cb0a8012cdd0b8a5bddfca7233f
https://openrepository.ru/article?id=675759

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Computational modelling suggests dynamic interactions between Ca 2+, IP3 and G protein-coupled modules are key to robust Dictyostelium aggregation

Autor: Valeyev N., Kim J., Heslop-Harrison J., Postlethwaite I., Kotov N., Bates D.

Publikováno v: SCOPUS1742206X-2009-5-6-SID65949100168

Under conditions of starvation, Dictyostelium cells begin a programme of development during which they aggregate to form a multicellular structure by chemotaxis, guided by propagating waves of cyclic AMP that are relayed robustly from cell to cell. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6b7ecc815bf236c325b52b699344dd49
https://dspace.kpfu.ru/xmlui/handle/net/139562

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Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels

Autor: Valeyev N., Heslop-Harrison P., Postlethwaite I., Gizatullina A., Kotov N., Bates D.

Publikováno v: SCOPUS1742206X-2009-5-1-SID57449100654

Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::041c278f44f17299c45d4ce6bd731650
https://openrepository.ru/article?id=671665

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Electrostatic and functional analysis of the seven-bladed WD beta-propellers

Autor: Valeyev, N, Downing, A, Sondek, J, Deane, C

Publikováno v: Evolutionary bioinformatics online. 4(4)

beta-propeller domains composed of WD repeats are highly ubiquitous and typically used as multi-site docking platforms to coordinate and integrate the activities of groups of proteins. Here, we have used extensive homology modelling of the WD40-repea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c0c8afd83f969e5db8abc6b62d302584
http://ora.ox.ac.uk/objects/uuid:e42d5ec4-7da1-4fe2-a279-dcd07b254bdd

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Multiple calcium binding sites make calmodulin multifunctional

Autor: Valeyev N., Heslop-Harrison P., Postlethwaite I., Kotov N., Bates D.

Publikováno v: SCOPUS1742206X-2007-4-1-SID37149050957

Protein-protein or protein-ion interactions with multisite proteins are essential to the regulation of intracellular and extracellular events. There is, however, limited understanding of how ligand-multisite protein interactions selectively regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2226062ef8bdf40e43fa49bd8646f5e8
https://openrepository.ru/article?id=671664

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A calcium dependent de-adhesion mechanism regulates the direction and rate of cell migration: A mathematical model

Autor: Valeyev, N. V., Downing, A. K., Skorinkin, A. I., Campbell, I. D., Nikolay Kotov

Publikováno v: SCOPUS13866338-2006-6-6-SID34250686188
Scopus-Elsevier

Cell migration has long been studied by a variety of techniques and many proteins have been implicated in its regulation. Integrins, key proteins that link the cell to the extracellular matrix, are central to adhesion complexes whose turnover defines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c102f314994ae898bb8414db71c9dce4
https://openrepository.ru/article?id=49165

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