Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.

Autor: Swan AL; MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, United Kingdom., Schütt C; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Rozman J; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Czech Center for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences,Vestec, Czech Republic., Del Mar Muñiz Moreno M; Université de Strasbourg, CNRS, INSERM, IGBMC, Illkirch, France., Brandmaier S; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Simon M; MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, United Kingdom., Leuchtenberger S; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Griffiths M; Mouse Informatics Group, Wellcome Sanger Institute, Hinxton, United Kingdom., Brommage R; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Keskivali-Bond P; MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, United Kingdom., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Werner T; Internal Medicine Nephrology and Center for Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America., Teperino R; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Becker L; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Miller G; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Moshiri A; University of California-Davis School of Medicine, Sacramento, California, United States of America., Seavitt JR; Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America., Cissell DD; Department of Surgical & Radiological Sciences, University of California, Davis, California, United States of America., Meehan TF; European Molecular Biology Laboratory- European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Acar EF; The Center for Phenogenomics, Toronto, Ontario, Canada.; The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Department of Statistics, University of Manitoba, Winnipeg, Manitoba, Canada., Lelliott CJ; Mouse Pipelines, Wellcome Sanger Institute, Hinxton, United Kingdom., Flenniken AM; The Center for Phenogenomics, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Champy MF; Université de Strasbourg, CNRS, INSERM, IGBMC, PHENOMIN-ICS, Illkirch, France., Sorg T; Université de Strasbourg, CNRS, INSERM, IGBMC, PHENOMIN-ICS, Illkirch, France., Ayadi A; Université de Strasbourg, CNRS, INSERM, IGBMC, PHENOMIN-ICS, Illkirch, France., Braun RE; The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, United States of America., Cater H; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, United Kingdom., Dickinson ME; Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.; Departments of Molecular Physiology & Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston,Texas, United States of America., Flicek P; European Molecular Biology Laboratory- European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Gallegos J; Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, United States of America., Ghirardello EJ; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, London, United Kingdom., Heaney JD; Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, United States of America., Jacquot S; Université de Strasbourg, CNRS, INSERM, IGBMC, PHENOMIN-ICS, Illkirch, France., Lally C; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, United Kingdom., Logan JG; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, London, United Kingdom., Teboul L; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, United Kingdom., Mason J; European Molecular Biology Laboratory- European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Spielmann N; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., McKerlie C; The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Murray SA; The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, United States of America., Nutter LMJ; The Center for Phenogenomics, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Odfalk KF; Advanced Technologies Cores, Baylor College of Medicine, One Baylor Plaza, Houston Texas, United States of America., Parkinson H; European Molecular Biology Laboratory- European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Prochazka J; Czech Center for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences,Vestec, Czech Republic., Reynolds CL; Departments of Molecular Physiology & Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston,Texas, United States of America., Selloum M; Université de Strasbourg, CNRS, INSERM, IGBMC, PHENOMIN-ICS, Illkirch, France., Spoutil F; Czech Center for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences,Vestec, Czech Republic., Svenson KL; The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, United States of America., Vales TS; Advanced Technologies Cores, Baylor College of Medicine, One Baylor Plaza, Houston Texas, United States of America., Wells SE; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, United Kingdom., White JK; The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, United States of America., Sedlacek R; Czech Center for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences,Vestec, Czech Republic., Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; Chair of Developmental Genetics, TUM School of Life Sciences (SoLS), Technische Universität München, Freising, Germany.; Deutsches Institut für Neurodegenerative Erkrankungen (DZNE) Site Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Adolf-Butenandt-Institut, Ludwig-Maximilians-Universität München, Munich, Germany., Lloyd KCK; Department of Surgery, School of Medicine and Mouse Biology Program, University of California Davis., Croucher PI; Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; St Vincent's Clinical School, Faculty of Medicine, Sydney, New South Wales, Australia.; School of Biotechnology and Biomolecular Sciences, UNSW Australia, Sydney, New South Wales, Australia., Fuchs H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Williams GR; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, London, United Kingdom., Bassett JHD; Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, London, United Kingdom., Gailus-Durner V; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Herault Y; Université de Strasbourg, CNRS, INSERM, IGBMC, Illkirch, France.; Université de Strasbourg, CNRS, INSERM, IGBMC, PHENOMIN-ICS, Illkirch, France., Mallon AM; MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, United Kingdom., Brown SDM; MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, United Kingdom., Mayer-Kuckuk P; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany., Hrabe de Angelis M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany.; Chair of Experimental Genetics, TUM School of Life Sciences (SoLS), Technische Universität München, Freising, Germany.

Publikováno v: PLoS genetics [PLoS Genet] 2020 Dec 28; Vol. 16 (12), pp. e1009190. Date of Electronic Publication: 2020 Dec 28 (Print Publication: 2020).