Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Valeryia Mikalayeva"'
Autor:
Rokas Mickus, Vytautas Raškevičius, Ieva Sarapinienė, Valeryia Mikalayeva, Rytis Prekeris, Vytenis Arvydas Skeberdis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116550- (2024)
Physiological and pathological processes such as homeostasis, embryogenesis, development, tumorigenesis, and cell movement depend on the intercellular communication through gap junctions (GJIC). Connexin (Cx)-based GJ channels are formed of two appos
Externí odkaz:
https://doaj.org/article/ae8dfed94c564e46a2098214cbaee73e
Mode of the Interaction of Efflux Inhibitor Phenylalanyl-arginyl-β-naphtylamide with Bacterial Cells
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1324 (2024)
An increased efflux activity is one of the major reasons for bacterial antibiotic resistance. The usage of efflux pump inhibitors could be a promising approach to restoring the activity of inefficient antibiotics. The interaction of the RND family ef
Externí odkaz:
https://doaj.org/article/7d33c7181c3e4be3b2958ea291e19e78
Autor:
Monika Pankevičiūtė-Bukauskienė, Valeryia Mikalayeva, Vaidotas Žvikas, V. Arvydas Skeberdis, Sergio Bordel
Publikováno v:
Molecules, Vol 28, Iss 11, p 4535 (2023)
A pipeline for metabolomics, based on UPLC-ESI-MS, was tested on two malignant breast cancer cell lines of the sub-types ER(+), PR(+), and HER2(3+) (MCF-7 and BCC), and one non-malignant epithelial cancer cell line (MCF-10A). This allowed us to quant
Externí odkaz:
https://doaj.org/article/e994b9d1c46a4e33b7747747b48a6768
Autor:
Rokas Mickus, Gintarė Jančiukė, Vytautas Raškevičius, Valeryia Mikalayeva, Inga Matulytė, Mindaugas Marksa, Kęstutis Maciūnas, Jurga Bernatonienė, Vytenis Arvydas Skeberdis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 135, Iss , Pp 111229- (2021)
Essential oils from plants are a potential source of molecules having anti-inflammatory, anticancer, cardiotropic, and other activities. However, most of these effects lack mechanistic explanations and structure–activity relationship testing. In th
Externí odkaz:
https://doaj.org/article/f687072fb0de49bcbe79af76b6192a7c
Autor:
Ieva Antanavičiūtė, Valeryia Mikalayeva, Ieva Ceslevičienė, Gintarė Milašiūtė, Vytenis Arvydas Skeberdis, Sergio Bordel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract A comparative analysis between cancer cell lines and healthy dividing cells was performed using data (289 microarrays and 50 RNA-seq samples) from 100 different cancer cell lines and 6 types of healthy stem cells. The analysis revealed two l
Externí odkaz:
https://doaj.org/article/b8fa77e54d9e4df0818a3bab0a846c01
Publikováno v:
Molecules, Vol 26, Iss 11, p 3386 (2021)
Bacterial resistance to antibiotics due to increased efficiency of the efflux is a serious problem in clinics of infectious diseases. Knowledge of the factors affecting the activity of efflux pumps would help to find the solution. For this, fast and
Externí odkaz:
https://doaj.org/article/6674bd4d5aae47f78a4ad2be3dfdee4f
Autor:
Aurelija Noreikaitė, Ieva Antanavičiūtė, Valeryia Mikalayeva, Adas Darinskas, Tomas Tamulevičius, Erika Adomavičiūtė, Linas Šimatonis, Dalia Akramienė, Edgaras Stankevičius
Publikováno v:
Medicina, Vol 53, Iss 3, Pp 203-210 (2017)
Objective: The aim of this study was to test polymeric materials (collagen, fibrin, polyimide film, and polylactic acid) for single- and multi-layer scaffold formation. Materials and methods: In our study, we used rabbit bone marrow stem cells (rBMSC
Externí odkaz:
https://doaj.org/article/53216fbf6b6b406abc044c82a8541ee2
Publikováno v:
Medicina, Vol 53, Iss 2, Pp 122-130 (2017)
Background and objective: One of the main causes of bacterial resistance to antimicrobials is multidrug resistance induced by the increased efficiency of the efflux pumps. In this study we analyzed how the conditions of assay affect the efflux of ind
Externí odkaz:
https://doaj.org/article/fb8ce66fe38f477fba2102f5a326adaa
Autor:
Vytautas Raškevičius, Valeryia Mikalayeva, Ieva Antanavičiūtė, Ieva Ceslevičienė, Vytenis Arvydas Skeberdis, Visvaldas Kairys, Sergio Bordel
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190636 (2018)
In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as tools for drug design. By comparing the chemical structures of human metabolites (obtained using their KEGG indexes) and the compounds contained in the DrugBank data
Externí odkaz:
https://doaj.org/article/5f6f2bc6f1eb4c07a8cb594ade95dc71
Autor:
Valeryia Mikalayeva, Ieva Ceslevičienė, Ieva Sarapinienė, Vaidotas Žvikas, Vytenis Arvydas Skeberdis, Valdas Jakštas, Sergio Bordel
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1348 (2019)
Both cytosolic fatty acid synthesis (FAS) and mitochondrial fatty acid oxidation (FAO) have been shown to play a role in the survival and proliferation of cancer cells. This study aimed to confirm experimentally whether FAS and FAO coexist in breast
Externí odkaz:
https://doaj.org/article/24f38e4c427d421792c165460264c99d