Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Valery Yu Alakhov"'
Autor:
Alexandre Semov, Ludmila Iourtchenco, Xiaoxue Su, Liu Lin Fang, Li Shengmin, Valery Yu Alakhov, Ekaterina Muyjnek, Yan Xu, Vsevolod Kiselev
Publikováno v:
Biochemical and Biophysical Research Communications. 424:45-51
Epidemiologic studies repeatedly have shown chemopreventive effects of cruciferous vegetables. Indole-3-carbinol (I3C) and its metabolite diindolylmethane (DIM) were identified in these plants as active ingredients and theirs anti-tumor activities we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e29a45e153efd4c6e016c25374a70b
https://doi.org/10.1016/j.bbrc.2012.06.062
https://doi.org/10.1016/j.bbrc.2012.06.062
Autor:
Elena V. Batrakova, Anna M. Brynskikh, Amit Sharma, Yili Li, Alexander V. Kabanov, Michael D. Boska, Valery Yu Alakhov, Howard E. Gendelman, R. Lee Mosley, Shu Li, Nan Gong
Publikováno v:
Journal of Controlled Release. 143:290-301
Cancer chemotherapy is believed to be impeded by multidrug resistance (MDR). Pluronic (triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), PEO-b-PPO-b-PEO) were previously shown to sensitize MDR tumors to antineoplastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8617ee44f25303132aabdcfb5e0abf12
https://doi.org/10.1016/j.jconrel.2010.01.004
https://doi.org/10.1016/j.jconrel.2010.01.004
Publikováno v:
Biomaterials. 30:1232-1245
DNA vaccines can be greatly improved by polymer agents that simultaneously increase transgene expression and activate immunity. We describe here Pluronic P85 (P85), a triblock copolymer of ethylene oxide (EO) and propylene oxide (PO) EO(26)-PO(40)-EO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ae195e9806b12479fd3dcf147ea7e3
https://doi.org/10.1016/j.biomaterials.2008.10.064
https://doi.org/10.1016/j.biomaterials.2008.10.064
Autor:
Shu Li, Alexander V. Kabanov, Amit K. Sharma, Li Zhang, David Lee Kelly, Elena V. Batrakova, Valery Yu Alakhov
Publikováno v:
Journal of Controlled Release. 131:220-227
Doxorubicin (Dox) incorporated in nanosized polymeric micelles, SP1049C, has shown promise as monotherapy in patients with advanced esophageal carcinoma. The formulation contains amphiphilic block copolymers, Pluronics, that exhibit the unique abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e10bdec1695bc5b399fd48fef446d3
https://doi.org/10.1016/j.jconrel.2008.07.031
https://doi.org/10.1016/j.jconrel.2008.07.031
Publikováno v:
Current Opinion in Colloid & Interface Science. 11:217-223
The major premise of gene therapy is that the delivery of nucleic acids into human cells can cure cancer and viral infections. Synthetic vectors based on cationic polymers that bond with the nucleic acids via electrostatic interactions to form polypl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25cd3240b5a62efa09d52bf3e282ff83
https://doi.org/10.1016/j.cocis.2006.07.001
https://doi.org/10.1016/j.cocis.2006.07.001
Autor:
Alexander V. Kabanov, Srikanth Sriadibhatla, Zhihui Yang, Valery Yu Alakhov, Catherine L. Gebhart
Publikováno v:
Molecular Therapy. 13(4):804-813
Amphiphilic block copolymers of poly(ethylene oxide) and poly(propylene oxide) (Pluronics) enhance gene expression, but the mechanism remains unclear. We examined the effects of Pluronics on gene expression in murine cell models (NIH3T3 fibroblasts,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66eacf48d2243f0bf689fc2231aaff1
Autor:
Hanns Lochmüller, Marita Pohlschmidt, Matthieu D. Lavigne, Geoffrey Goldspink, Hitoshi Sakuraba, Bernard Higgins, K D MacDermot, Javier F. Novo, Valery Yu Alakhov, Dariusz C. Górecki
Publikováno v:
Molecular Therapy. 12(5):985-990
Top of pageAbstract Anderson-Fabry disease is an X-linked lysosomal storage disorder (LSD) caused by |[alpha]|-galactosidase A (AGA) deficiency. There is evidence that LSDs could be corrected by gene transfer, expression and enzyme secretion from a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4daf891a5411cf7bfd2ed897909008b6
Autor:
Valery Yu Alakhov, Zhihui Yang, Srikanth Sriadibhatla, Catherine L. Gebhart, Alexander V. Kabanov, Jian Zhu
Publikováno v:
Journal of Controlled Release. 108:496-512
Amphiphilic triblock copolymers of ethylene oxide and propylene oxide (Pluronic) significantly enhanced expression of plasmid DNA in the skeletal muscle. In the presence of Pluronic P85 (P85) high levels of expression of a reporter gene (luciferase)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43569e322c04eb843b660b021b456443
https://doi.org/10.1016/j.jconrel.2005.08.015
https://doi.org/10.1016/j.jconrel.2005.08.015
Autor:
Shu Li, Alexander V. Kabanov, Elena V. Batrakova, Tamara Minko, Refika I. Pakunlu, Yili Li, Valery Yu Alakhov
Publikováno v:
Journal of Controlled Release. 105:269-278
Pluronic block copolymer P85 (P85) sensitizes multidrug resistant (MDR) cancer cells resulting in the increase of cytotoxic activity of antineoplastic agents. This effect is attributed to the inhibition of the most clinically relevant drug efflux tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705d2fff7afba539275c75f0635b927e
https://doi.org/10.1016/j.jconrel.2005.03.019
https://doi.org/10.1016/j.jconrel.2005.03.019
Publikováno v:
Langmuir. 21:1590-1598
Spherical particles of 50-100 mum size composed of poly(acrylic acid) networks covalently bonded to Pluronic polyether copolymers were tested for swelling in aqueous media. The microgels were cross-linked either by permanent ethylene glycol dimethacr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac266c6183cfe2ef06d3b2dfa09f653f
https://doi.org/10.1021/la047893j
https://doi.org/10.1021/la047893j