Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Valery S. Kochubey"'
Autor:
Ilya I. Afanasyev, Valery S. Kochubey, Natalya I. Vasilevich, Dmitry A. Kovalskiy, Dmitry V. Genis
Publikováno v:
Chemical biologydrug design. 84(5)
The general model of epitope-type MDM2 inhibitor was developed based on the structural information on the complexes between MDM2 and various low molecular weight ligands found in the PDB database. Application of this model to our in-house library has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a8a0512083831500a04e513f0472da
https://pubmed.ncbi.nlm.nih.gov/24797588
https://pubmed.ncbi.nlm.nih.gov/24797588
Autor:
Eugene A. Rastorguev, Valery S. Kochubey, Ilya I. Afanasyev, Natalya I. Vasilevich, Dmitry V. Genis
Publikováno v:
MedChemComm. 4:1597
A new class of alpha-helix mimetics, based on the phenyl-pyrazole-phenyl (6-5-6) system, has been designed and synthesized. The ability of the new compounds to inhibit PPIs was confirmed using an MDM2-p53 binding assay. The library, containing comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b186170ba7205dfb97ab4132fd526c2
https://doi.org/10.1039/c3md00211j
https://doi.org/10.1039/c3md00211j