Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Valery M. Gordon"'
Publikováno v:
Clinical and Translational Science. 10:130-132
For nearly 50 years, the Common Rule has required Institutional Review Board (IRB) oversight of federally-funded research to protect the rights and welfare of human research participants. Over time, research has changed and research studies often inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a327ced95c302496c608fd8af07ce94f
https://doi.org/10.1111/cts.12447
https://doi.org/10.1111/cts.12447
Autor:
Stephen H. Leppla, George F. Vande Woude, Terry D. Copeland, M Oskarsson, Kenji Fukasawa, Nicholas S. Duesbery, Kurt Klimpel, Valery M. Gordon, Craig P. Webb, Natalie G. Ahn, Ken D. Paull
Publikováno v:
Science. 280:734-737
Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of death in animals infected with anthrax. One component of this toxin, lethal factor (LF), is suspected to be a metalloprotease, but no physiological substrates h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9692bd4d99c2732083177cc0e64c713d
https://doi.org/10.1126/science.280.5364.734
https://doi.org/10.1126/science.280.5364.734
Publikováno v:
Infection and Immunity. 65:4130-4134
Clostridium septicum alpha-toxin is secreted as an inactive 46,450-Da protoxin. The protoxin is activated by proteolytic cleavage near the C terminus, which eventually causes the release of a 45-amino-acid fragment. Proteoytic activation and loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadd1e4a678d66c75a34b5497f32453e
https://doi.org/10.1128/iai.65.10.4130-4134.1997
https://doi.org/10.1128/iai.65.10.4130-4134.1997
Publikováno v:
The Journal of Clinical Ethics. 7:349-354
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12cb8c02b4c581d42d0e3c87912f675c
https://doi.org/10.1086/jce199607411
https://doi.org/10.1086/jce199607411
Publikováno v:
Infection and Immunity. 63:82-87
Before intoxication can occur, anthrax toxin protective antigen (PA), Pseudomonas exotoxin A (PE), and diphtheria toxin (DT) must be activated by proteolytic cleavage at specific amino acid sequences. Previously, it was shown that PA and DT can be ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770aa75b43914189e0780b595b1226f9
https://doi.org/10.1128/iai.63.1.82-87.1995
https://doi.org/10.1128/iai.63.1.82-87.1995
Publikováno v:
IRB. 20(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f30386ca4ea927185c8ca27ac34584c
https://pubmed.ncbi.nlm.nih.gov/11655324
https://pubmed.ncbi.nlm.nih.gov/11655324
Autor:
Stephen H. Leppla, Kim L. Nelson, Patrick C. Elwood, J. Thomas Buckley, Rodney K. Tweten, Victoria L. Stevens, Valery M. Gordon
Publikováno v:
The Journal of biological chemistry. 274(38)
The alpha toxin produced by Clostridium septicum is a channel-forming protein that is an important contributor to the virulence of the organism. Chinese hamster ovary (CHO) cells are sensitive to low concentrations of the toxin, indicating that they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e38a18d67b12dd3b47d377d9de12840
https://pubmed.ncbi.nlm.nih.gov/10480947
https://pubmed.ncbi.nlm.nih.gov/10480947
Publikováno v:
Infection and immunity. 65(8)
Several bacterial protein toxins require activation by eukaryotic proteases. Previous studies have shown that anthrax toxin protective antigen (PA), Pseudomonas exotoxin A (PE), and diphtheria toxin (DT) are cleaved by furin C-terminal to the sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ddc591153a87cb1dabb11ead21379c
https://pubmed.ncbi.nlm.nih.gov/9234799
https://pubmed.ncbi.nlm.nih.gov/9234799
Publikováno v:
Infection and immunity. 64(2)
Pseudomonas exotoxin A (PE) binds and enters mammalian cells via the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP). The toxin then requires proteolytic cleavage to generate an enzymatically active fragment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972ae18084f89581be96a3bbc712687e
https://pubmed.ncbi.nlm.nih.gov/8550202
https://pubmed.ncbi.nlm.nih.gov/8550202
Autor:
Stephen H. Leppla, Valery M. Gordon
Publikováno v:
Infection and immunity. 62(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97218df173ffb5f87e60d77d93caeb1
https://pubmed.ncbi.nlm.nih.gov/8300195
https://pubmed.ncbi.nlm.nih.gov/8300195