Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Valery Krizhanovsky"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
One of the underlying causes of aging is the accumulation of senescent cells, but their turnover rates and dynamics during ageing are unknown. Here the authors measure and model senescent cell production and removal and explore implications for morta
Externí odkaz:
https://doaj.org/article/c8d1148874e54b7f9c4cf46bb629afe1
Autor:
Yossi Ovadya, Tomer Landsberger, Hanna Leins, Ezra Vadai, Hilah Gal, Anat Biran, Reut Yosef, Adi Sagiv, Amit Agrawal, Alon Shapira, Joseph Windheim, Michael Tsoory, Reinhold Schirmbeck, Ido Amit, Hartmut Geiger, Valery Krizhanovsky
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Senescent cells accumulate with aging contributing to age-related disease and the role of the immune system in removing senescent cells is not completely understood. Here, the authors show that perforin deficient mice accumulate more senescent cells
Externí odkaz:
https://doaj.org/article/a1ec80e65b354c269b44d215e404c1cc
Autor:
Adi Sagiv, Amir Bar-Shai, Naama Levi, Miki Hatzav, Lior Zada, Yossi Ovadya, Lior Roitman, Gal Manella, Ofer Regev, Julia Majewska, Ezra Vadai, Raya Eilam, Sara W. Feigelson, Michael Tsoory, Michel Tauc, Ronen Alon, Valery Krizhanovsky
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3468-3479 (2018)
Summary: The tumor suppressor p53 limits tumorigenesis by inducing apoptosis, cell cycle arrest, and senescence. Although p53 is known to limit inflammation during tumor development, its role in regulating chronic lung inflammation is less well under
Externí odkaz:
https://doaj.org/article/3f1c19548e7f4fcf87e7ad6139d3663b
Autor:
Maicol Mancini, Hilah Gal, Nadège Gaborit, Luigi Mazzeo, Donatella Romaniello, Tomer Meir Salame, Moshit Lindzen, Georg Mahlknecht, Yehoshua Enuka, Dominick GA Burton, Lee Roth, Ashish Noronha, Ilaria Marrocco, Dan Adreka, Raya Eilam Altstadter, Emilie Bousquet, Julian Downward, Antonio Maraver, Valery Krizhanovsky, Yosef Yarden
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 294-308 (2017)
Abstract Epidermal growth factor receptor (EGFR) mutations identify patients with lung cancer who derive benefit from kinase inhibitors. However, most patients eventually develop resistance, primarily due to the T790M second‐site mutation. Irrevers
Externí odkaz:
https://doaj.org/article/29209c6b4c714c0b85c5ff5816ce736b
Autor:
Reut Yosef, Noam Pilpel, Ronit Tokarsky-Amiel, Anat Biran, Yossi Ovadya, Snir Cohen, Ezra Vadai, Liat Dassa, Elisheva Shahar, Reba Condiotti, Ittai Ben-Porath, Valery Krizhanovsky
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The accumulation of senescent cells within tissues plays a role in numerous age-related pathologies. Yosef and Pilpel et al. demonstrate that the resistance of these cells to apoptosis is driven by upregulation of survival proteins, whose pharmacolog
Externí odkaz:
https://doaj.org/article/560479e5b34747fb9d70b2a5aea7e0c2
Autor:
Lina Abu-Tair, Jonathan H Axelrod, Sarit Doron, Yossi Ovadya, Valery Krizhanovsky, Eithan Galun, Johnny Amer, Rifaat Safadi
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82571 (2013)
The toll-like receptor-9 (TLR9) agonist cytosine phosphate guanine (CpG), activates hepatic stellate cells (HSCs) and mediates fibrosis. We investigated the TLR9 effects on lymphocyte/HSCs interactions. Liver fibrosis was induced in wild-type (WT) mi
Externí odkaz:
https://doaj.org/article/dc94c8140179432990dd5cf30249f0e3
Autor:
Julia Majewska, Amit Agrawal, Avi Mayo, Lior Roitman, Rishita Chatterjee, Jarmila Kralova, Tomer Landsberger, Yonatan Katzenelenbogen, Tomer Meir-Salame, Efrat Hagai, Nemanja Stanojevic, Ido Amit, Uri Alon, Valery Krizhanovsky
The accumulation of senescent cells promotes aging, but a molecular mechanism that senescent cells use to evade immune clearance and accumulate remains to be elucidated. Here, we report that p16-positive senescent cells upregulate the immune checkpoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4e2f7227e83507ed7a204748568db2
https://doi.org/10.1101/2023.01.30.524522
https://doi.org/10.1101/2023.01.30.524522
Publikováno v:
Nat Rev Mol Cell Biol
Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology
Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions. Eminently characterized by a permanent proliferation arrest, cellular senescence occurs in res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a93654b9a7960c20bfd34dc1d98899
https://doi.org/10.1038/s41580-020-00314-w
https://doi.org/10.1038/s41580-020-00314-w
Publikováno v:
The FEBS Journal
The extracellular matrix (ECM) is a key noncellular component in all organs and tissues. It is composed of a large number of proteins including collagens, glycoproteins (GP), and ECM-associated proteins, which show diversity of biochemical and biophy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b020630b9c6b82199f4f2cfd493ddb0
https://doi.org/10.1111/febs.15282
https://doi.org/10.1111/febs.15282
Autor:
Nurit Papismadov, Valery Krizhanovsky
Publikováno v:
Nature Neuroscience. 24:2-4
One of the mechanisms driving aging and neurodegenerative diseases is the accumulation of senescent cells, while their elimination mitigates age-related decline. A new report details how, with aging, changes in the dentate gyrus microenvironment lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7510b81b79034bbdc01df06a6751099b
https://doi.org/10.1038/s41593-020-00749-6
https://doi.org/10.1038/s41593-020-00749-6