Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Valery I. Kapelko"'
Publikováno v:
Kardiologiia. 60:98-102
Aim An attempt to prevent the development of diastolic dysfunction (DD) with the mitochondrial antioxidant plastomitin on a model of doxorubicin-induced cardiomyopathy. DD is a type of chronic heart failure. Due to the increasing number of patients w
Autor:
Irina Studneva, Valery I. Kapelko, A D Ulanova, I M Vikhlyantsev, A. V. Prosvirnin, Vladimir L. Lakomkin, A A Abramov, E. V. Lukoshkova
Publikováno v:
Kardiologiia. 60:4-9
Relevance. Diastolic dysfunction occurring at hypertension, obesity, diabetes, or treatment with doxorubicin tends to prevail in all patterns of chronic heart failure. Lack of effective therapy forces to look more into the metabolic processes in card
Publikováno v:
Kardiologiia. 59:35-41
The aim of the study was to ascertain whether the use of plastomitin, the mitochondrial antioxidant, can affect the development of systolic dysfunction that occurs in rats after 4 weeks of doxorubicin treatment (2 mg/kg weekly). Materials and methods
Autor:
Vladimir L. Lakomkin, O. N. Vyborov, Irina Studneva, Oleg I. Pisarenko, O M Veselova, A. V. Prosvirnin, Valery I. Kapelko, A. A. Abramov, E R Pavlovich, R O Lubimov, V. V. Gramovich
Publikováno v:
Kardiologiia. 17:66-74
AIM To study effects of intravenous infusion of a cardioprotective drug metilin, developed at the "National Medical Research Center of Cardiology" on indices of cardiac function in rabbits in vivo after prolonged administration of doxorubicin. MATERI
Autor:
Mikhail S. Novikov, A A Abramov, Alexander A. Makarov, Vladimir A. Mitkevich, Irina Yu. Petrushanko, Valentina A. Lakunina, Yuri M. Poluektov, Asker Y. Khapchaev, Vladimir P. Shirinsky, Valery I. Kapelko, Vladimir L. Lakomkin, Nidas A. Undrovinas
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Severe hypoxia leads to decline in cardiac contractility and induces arrhythmic events in part due to oxidative damage to cardiomyocyte proteins including ion transporters. This results in compromised handling of Ca2+ ions that trigger heart contract
Autor:
Valery I. Kapelko, V. V. Gramovich, A A Abramov, Oleg I. Pisarenko, Vladimir L Lakomkin, Irina Studneva, Oleg Vyborov
Publikováno v:
Europe PubMed Central
The aim of the study was comparison of contractile function of isolated hearts of rats with doxorubicin-induced myocardial injury which were tentatively divided according to the level of ejection fraction determined by echocardiography in vivo. After
Autor:
Vladimir L. Lakomkin, Elena V Lukoshkova, Valery I. Kapelko, Nidas A. Undrovinas, Vladimir P. Shirinsky, Asker Y. Khapchaev, A A Abramov
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Background. Nitric oxide can successfully compete with oxygen for sites of electron-transport chain in conditions of myocardial hypoxia. These features may prevent excessive oxidative stress occurring in cardiomyocytes during sudden hypoxia-reoxygena
Autor:
V. V. Gramovich, Valery I. Kapelko, V S Abramov, V. V. Ermishkin, Vladimir L. Lakomkin, Zhdanov Vs, O. N. Vyborov, S P Veselova, Shirinskiĭ Vp, E. V. Lukoshkova, S V Lakomkin, N A Undrovinas
Publikováno v:
Kardiologiia. :46-56
Introduction of isoproterenol (an agonist of beta-adrenoreceptors) to rats is one of the widespread experimental models of cardiac failure. It is caused by damage of cardiomyocytes with the subsequent development of substitutive fibrosis. The purpose
Autor:
Konstantin B. Shumaev, Yu N Belenkov, A. K. Tikhaze, Valery I. Kapelko, Galina G. Konovalova, Vadim Z. Lankin, G. S. Shepelkova, O M Panasenko
Publikováno v:
Biochemistry (Moscow). 72:1081-1090
Low-molecular-weight aldehydes (glyoxal, methylglyoxal, 3-deoxyglucosone) generated on autooxidation of glucose under conditions of carbonyl stress react much more actively with amino groups of L-lysine and epsilon-amino groups of lysine residues of
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Prolonged hypotensive effect of oxacom (dinitrosyl iron complexes with ligand glutathione) has been well documented in animals and healthy volunteers, but effect on the heart is not defined. In this work, the blood pressure (BP), and the pressure in