Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Valery Barillaro"'
Autor:
Georges Dive, Pascal Bertholet, Valery Barillaro, Eric Ziemons, Luc Delattre, Géraldine Piel, Brigitte Evrard
Publikováno v:
International Journal of Pharmaceutics. 350:155-165
The geometry, frequency and intensity of the vibrational bands of miconazole were derived from the density functional theory (DFT) calculations with the hybrid functional B3LYP and the 6-31G(d) basis set. Starting from the fully AM1 optimized geometr
Autor:
Luc Delattre, Ziemons Eric, Georges Dive, Géraldine Piel, Brigitte Evrard, Pascal Bertholet, Valery Barillaro
Publikováno v:
International Journal of Pharmaceutics. 342:152-160
The inclusion of miconazole into cyclodextrin cavity has been demonstrated by different authors. Preliminary studies have shown which fragment of the molecule is involved in the inclusion. In the present study, AM1 approximate molecular orbital calcu
Autor:
Géraldine Piel, Brigitte Evrard, Luc Delattre, Marie Piette, Valery Barillaro, Delphine Castagne
Publikováno v:
International Journal of Pharmaceutics. 338:35-42
It is well known that cyclodextrins are able to extract lipids constituting membranes, increasing their fluidity and permeability. This behaviour towards biological membranes is directly linked to the toxicological effects of methylated cyclodextrins
Autor:
Eric Ziemons, Luc Angenot, N. Wandji Mbakop, Valery Barillaro, Ph. Hubert, Léopold Thunus, E. Rozet, Robert Lejeune
Publikováno v:
Talanta. 71:911-917
Supercritical fluid extraction (SFE) with carbon dioxide as extraction medium was on-line coupled to a FT-IR spectrometer equipped with a Mercury Cadmium Telluride (MCT) detector using a tailor-made high-pressure fibre optic flow cell. This method wa
Autor:
Michel Frederich, Philippe Hubert, Luc Angenot, Georges Dive, Luc Delattre, Benjamin Debrus, Eric Ziemons, Valery Barillaro, Léopold Thunus, Robert Lejeune
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 43:910-919
The inclusion complexes of tagitinin C with beta-, 2,6-di-O-methyl-beta- and gamma-cyclodextrin (CyD) was investigated in aqueous medium. The stoichiometric ratios and stability constants (K(f)) which describe the extent of formation of the complexes
Publikováno v:
The AAPS Journal. 7:E149-E155
The objective of this study was to determine the pharmacokinetic parameters of miconazole after oral administration of a miconazole/hydroxypropyl-gamma-cyclodextrin(HPgammaCD)/L-tartaric acid inclusion complex produced by supercritical carbon dioxide
Autor:
S. Henry de Hassonville, Valery Barillaro, Georges Dive, Géraldine Piel, Brigitte Evrard, Pascal Bertholet, Luc Delattre
Publikováno v:
Journal of Drug Delivery Science and Technology. 14:357-362
The ability of cyclodextrins (CDs) to increase the solubility of cyproterone acetate (CPA) was previously shown by phase-solubility and NMR studies [1]. In the present work, the influence of various CDs on the stability of CPA was studied in pH 6 and
Autor:
Bruno Perly, Stephane Moutard, Brigitte Evrard, Pascal Bertholet, Luc Delattre, Valery Barillaro, Géraldine Piel, Marie Piette, S. Henry de Hassonville
Publikováno v:
Journal of Drug Delivery Science and Technology. 14:87-91
Two methods usually used in the literature to determine stability constant values (Kc) of cyclodextrin complexes were compared: the phase solubility diagram and NMR spectroscopy. Two model drugs were used to determine limitations of both techniques:
Autor:
Sandrine Henry de Hassonville, Brigitte Evrard, Géraldine Piel, Luc Delattre, Valery Barillaro, Thierry Van Hees, Pascal Bertholet
Publikováno v:
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 44:271-274
Inclusion complexes of drugs into cyclodextrins (CDs) can be obtained at the solid state by means of supercritical dioxide (SCCO2). A successful inclusion with a yield >98.5% has been achieved with piroxicam and β-CD. The temperature and the time of
Autor:
Delphine Castagne, Géraldine Piel, Marie Piette, Brigitte Evrard, Luc Delattre, Valery Barillaro
Publikováno v:
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 57:309-311
We wanted to compare and understand the effect of the most currently used cyclodextrins on a model membrane. We studied the influence of most currently used cyclodextrins on the release of a fluorescent marker encapsulated in the inner cavity of SUV