Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Valery Sudakin"'
Autor:
Valery Sudakin, Tim J. Yen
Publikováno v:
BioDrugs. 21:225-233
Basic research that has focused on achieving a mechanistic understanding of mitosis has provided unprecedented molecular and biochemical insights into this highly complex phase of the cell cycle. The discovery process has uncovered an ever-expanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0a3d3c8f851ecece0541a236c35139
https://doi.org/10.2165/00063030-200721040-00003
https://doi.org/10.2165/00063030-200721040-00003
Autor:
A Hershko, Joan V. Ruderman, L H Cohen, Dvorah Ganoth, Esther Eytan, F. C. Luca, Aviva Dahan, Valery Sudakin
Publikováno v:
Journal of Biological Chemistry. 269:4940-4946
Cyclin B, a positive regulatory subunit of the cdc2 protein kinase complex, is synthesized across the cell cycle and then rapidly degraded at the end of mitosis. Degradation of cyclin B is triggered by increased levels of active cdc2 and is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8abe9ea7e44ac27a822b303344c3b636
https://doi.org/10.1016/s0021-9258(17)37636-6
https://doi.org/10.1016/s0021-9258(17)37636-6
Autor:
William H. Miller, Stuart Paul Romeril, Jesus R. Medina, Valery Sudakin, Sridhar K. Rabindran, Dirk A. Heerding, Mark A. Bobko, Jeffrey M. Axten, Celine Duquenne, Antony Chadderton, Melissa Dumble, Seth A. Gilbert, Charles W. Blackledge, Arthur Shu, Daryl A. Scherzer, Nino Campobasso, Christopher Becker, Hong Xiang, William Hoi Hong Li, Pat Brady, Qi Liu, Paris Ward, Christine M. Gardiner, Seth W. Grant, Yanhong Feng
Publikováno v:
Journal of medicinal chemistry. 54(6)
Phosphoinositide-dependent protein kinase-1(PDK1) is a master regulator of the AGC family of kinases and an integral component of the PI3K/AKT/mTOR pathway. As this pathway is among the most commonly deregulated across all cancers, a selective inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93d15e6b5f7bd8cebc8e5bc463c5405
https://pubmed.ncbi.nlm.nih.gov/21341675
https://pubmed.ncbi.nlm.nih.gov/21341675
Autor:
Jeffrey R. Jackson, Latesh Lad, Ruth Lehr, Kurt R. Auger, Huizhen Zhao, Amita M. Chaudhari, Sharon Sweitzer, Jeffery D Carson, Neysa Nevins, Lusong Luo, Pearl S. Huang, Kenneth W. Wood, Valery Sudakin, Antony N. Shaw, Dashyant Dhanak, Dean E. McNulty, Cynthia A. Parrish, Roland S. Annan, Robert A. Copeland, Roman Sakowicz
Publikováno v:
Nature chemical biology. 3(11)
The mitotic kinesin KSP (kinesin spindle protein, or Eg5) has an essential role in centrosome separation and formation of the bipolar mitotic spindle. Its exclusive involvement in the mitotic spindle of proliferating cells presents an opportunity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86c4a6be9add1bd52eaa0b7b31b4256
https://pubmed.ncbi.nlm.nih.gov/17922005
https://pubmed.ncbi.nlm.nih.gov/17922005
Autor:
Valery Sudakin, Tim J. Yen
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase-promoting complex/cyclosome (APC/C) from targeting key proteins for ubiquitin-mediated proteolysis. Great efforts have been m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a8a03c827afcd07b9f10a742d152317
https://doi.org/10.1385/1-59259-811-0:199
https://doi.org/10.1385/1-59259-811-0:199
Autor:
Priya, Chaturvedi, Valery, Sudakin, Matthew L, Bobiak, Paul W, Fisher, Michael R, Mattern, Sandra A, Jablonski, Mark R, Hurle, Yuan, Zhu, Tim J, Yen, Bin-Bing S, Zhou
Publikováno v:
Cancer research. 62(6)
Resistance to chemotherapy targeting microtubules could be partially because of the delay in chromosome condensation and segregation during mitosis. The Chfr pathway has been defined recently, and its activation causes a delay in chromosome condensat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5a0cea20e3a6a6017f5e380549ccd33
https://pubmed.ncbi.nlm.nih.gov/11912157
https://pubmed.ncbi.nlm.nih.gov/11912157
Publikováno v:
The Journal of Cell Biology
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase-promoting complex/cyclosome (APC/C) from targeting key proteins for ubiquitin-mediated proteolysis. We have examined the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd22f5356904b3552bc9c7c5669402ae
https://pubmed.ncbi.nlm.nih.gov/11535614
https://pubmed.ncbi.nlm.nih.gov/11535614
Publikováno v:
The Journal of Cell Biology
Human cells express two kinases that are related to the yeast mitotic checkpoint kinase BUB1. hBUB1 and hBUBR1 bind to kinetochores where they are postulated to be components of the mitotic checkpoint that monitors kinetochore activities to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a72f0a348a530e6fc1d0979673f016c
https://pubmed.ncbi.nlm.nih.gov/10477750
https://pubmed.ncbi.nlm.nih.gov/10477750
Publisher Summary This chapter discusses the preparation of clam oocyte extracts for cell cycle studies. It was in clam oocytes that cyclins were first identified, cloned, and sequenced, the biological activity of cyclins was first demonstrated, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80bc01214c682552cea3ff0f8bfaca74
https://doi.org/10.1016/s0076-6879(97)83048-0
https://doi.org/10.1016/s0076-6879(97)83048-0
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(20)
Cyclin B/cdc2 is responsible both for driving cells into mitosis and for activating the ubiquitin-dependent degradation of mitotic cyclins near the end of mitosis, an event required for the completion of mitosis and entry into interphase of the next
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd13984cad376d922bfebc44008fbb4d
https://pubmed.ncbi.nlm.nih.gov/7568122
https://pubmed.ncbi.nlm.nih.gov/7568122