The coin toss of B cells in rejection and tolerance: Danger versus defense

Autor: Minnie M. Sarwal, Valeriya Zarkhin

Publikováno v: Seminars in Immunology. 24:86-91

Transplantation is the preferred therapy for the end stage organ disease. Since the introduction of organ transplantation into medical practice in 1953 [1], significant progress has been achieved in patient and graft survival rates due to improvement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379b3b648a673bc3969489fe9ba30925
https://doi.org/10.1016/j.smim.2011.09.003

Expression of Soluble HLA-G Identifies Favorable Outcomes in Liver Transplant Recipients

Autor: Valeriya Zarkhin, Sue V. McDiarmid, Li Li, Minnie M. Sarwal, Carlos O. Esquivel, Kenneth L. Cox, Anita Talisetti, Laura J. Wozniak

Publikováno v: Transplantation. 90:1000-1005

Background Human leukocyte antigen (HLA)-G displays immunotolerogenic properties toward the main effector cells involved in graft rejection through inhibition of natural killer cell- and cytotoxic T-lymphocyte-mediated cytolysis, and CD4 T-cell allop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b403fa74fba7ee06817ac5d41ec7692
https://doi.org/10.1097/tp.0b013e3181f546af

A Five-Gene Peripheral Blood Diagnostic Test for Acute Rejection in Renal Transplantation

Autor: Vikas R. Dharnidharka, Amery Chen, Tara K. Sigdel, David B. Kershaw, M. Zhang, Minnie M. Sarwal, Bradley A. Warady, Rong Chen, Robert B. Ettenger, Oscar Salvatierra, Ruth A. McDonald, V. M. Vehaskari, Hong Dai, Tim Q. Tran, Szu-Chuan Hsieh, M. Vitalone, Valeriya Zarkhin, Rasika A. Mathias, Poonam Sansanwal, Wenzhong Xiao, Purvesh Khatri, M. Benfield, Anthony A. Portale, Maarten Naesens, Ronald W. Davis, Lihua Ying, Atul J. Butte, Michael N. Mindrinos, H. J. Baluarte, Li Li, Elaine S. Kamil, William E. Harmon

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 12, iss 10

Monitoring of renal graft status through peripheral blood (PB) rather than invasive biopsy is important as it will lessen the risk of infection and other stresses, while reducing the costs of rejection diagnosis. Blood gene biomarker panels were disc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18563b4fe8feb71550b05902384300a2
https://europepmc.org/articles/PMC4148014/

The yin and yang of B cells in graft rejection and tolerance

Autor: Valeriya Zarkhin, Minnie M. Sarwal, Geetha Chalasani

Publikováno v: Transplantation reviews (Orlando, Fla.). 24(2)

Various lineages of B cells are being increasingly recognized as important players in the etiology and prognosis of both acute and chronic graft rejection. The role of immature, chronically activated B cells, as efficient antigen-presenting cells, su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17d5fe7cc3e5ed705f311be2b1ef3f8
https://pubmed.ncbi.nlm.nih.gov/20149626

A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation

Autor: Neeraja Kambham, Tara K. Sigdel, Lulin Li, Minnie M. Sarwal, Valeriya Zarkhin, Oscar Salvatierra

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 8(12)

We report 1-year outcomes of a randomized study of Rituximab versus standard-of-care immunosuppression (Thymoglobulin and/or pulse steroids) for treatment of biopsy confirmed, acute transplant rejection with B-cell infiltrates, in 20 consecutive reci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c696f7d56e044ae18a8178c4e7fe15e
https://pubmed.ncbi.nlm.nih.gov/19032220