Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Valeriy G. Ostapchenko"'
Autor:
Rachel E. Lackie, Jose Marques-Lopes, Valeriy G. Ostapchenko, Sarah Good, Wing-Yiu Choy, Patricija van Oosten-Hawle, Stephen H. Pasternak, Vania F. Prado, Marco A. M. Prado
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Molecular chaperones and co-chaperones, which are part of the protein quality control machinery, have been shown to regulate distinct aspects of Alzheimer’s Disease (AD) pathology in multiple ways. Notably, the co-chaperone STI1, which pre
Externí odkaz:
https://doaj.org/article/9ee481f80095427e8c20de5968f11484
Autor:
Rachel E. Lackie, Andrzej Maciejewski, Valeriy G. Ostapchenko, Jose Marques-Lopes, Wing-Yiu Choy, Martin L. Duennwald, Vania F. Prado, Marco A. M. Prado
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
The accumulation of misfolded proteins in the human brain is one of the critical features of many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta-amyloid (Aβ) peptide—either soluble (oligomers) or insoluble (plaqu
Externí odkaz:
https://doaj.org/article/f10efba2407246aaabc056b22a623b95
Autor:
Valeriy G. Ostapchenko, Sara Matovic, Wei-Yang Lu, William Binning, Marco A. M. Prado, Mohammed A. Al-Onaizi, Diana Yae Sakae, Vania F. Prado, Matthew J.E. Maksoud, Aja E. Hogan-Cann, Wataru Inoue
Publikováno v:
Brain, Behavior, and Immunity. 88:791-801
Microglia express muscarinic G protein-coupled receptors (GPCRs) that sense cholinergic activity and are activated by acetylcholine to potentially regulate microglial functions. Knowledge about how distinct types of muscarinic GPCR signaling regulate
Autor:
P. J. Nicholls, Thomas F. Pack, Nikhil M. Urs, Sunil Kumar, Yang Zhou, Gabriel Ichim, Joshua D. Ginzel, Gabor Turu, Evan Calabrese, Wendy L. Roberts, Ping Fan, Valeriy G. Ostapchenko, Monica S. Guzman Lenis, Flavio Beraldo, Jiri Hatina, Vania F. Prado, Marco A. M. Prado, Ivan Spasojevic, Joshua C. Snyder, Kafui Dzirasa, G. Allan Johnson, Marc G. Caron
Publikováno v:
eNeuro
eNeuro, 2022, 9 (5), pp.ENEURO.0147-21.2022. ⟨10.1523/ENEURO.0147-21.2022⟩
eNeuro, 2022, 9 (5), pp.ENEURO.0147-21.2022. ⟨10.1523/ENEURO.0147-21.2022⟩
The protease caspase-3 is a key mediator of apoptotic programmed cell death. But weak or transient caspase activity can contribute to neuronal differentiation, axonal pathfinding, and synaptic long-term depression. Despite the importance of sublethal
Publikováno v:
Medical Biophysics Publications
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Introduction: Non-invasively distinguishing aggressive from non-aggressive brain tumors is an important clinical challenge. Intracellular pH (pHi) regulation is essential for nor
Autor:
Wing-Yiu Choy, Jose Marques-Lopes, Marco A. M. Prado, Stephen H. Pasternak, Vania F. Prado, Rachel E. Lackie, Sarah C. Good, Patricija van Oosten-Hawle, Valeriy G. Ostapchenko
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Molecular chaperones and co-chaperones, which are part of the protein quality control machinery, have been shown to regulate distinct aspects of Alzheimer’s Disease (AD) pathology in multiple ways. Notably, the co-chaperone STI1, which presents inc
Autor:
Flavio H. Beraldo, Valeriy G. Ostapchenko, Gianni M. Di Guglielmo, Marc G. Caron, Marco A. M. Prado, Jue Fan, Jason Z. Xu, Vania F. Prado, Peter J. Nicholls
Publikováno v:
J Neurochem
Anatomy and Cell Biology Publications
Anatomy and Cell Biology Publications
Stress-inducible phosphoprotein 1 (STI1) acts as a neuroprotective factor in the ischemic brain and its levels are increased following ischemia. Previous work has suggested that some of these STI1 actions in a stroke model depend on the recruitment o
Autor:
Jue Fan, Valeriy G. Ostapchenko, Robert Bartha, Blaine A. Chronik, Michael J. Kovacs, Robert H. E. Hudson, Stephen H. Pasternak, Vania F. Prado, M. Rebecca Cobb, Jonatan A. Snir, Mojmir Suchy, Marco A. M. Prado
Publikováno v:
Medical Biophysics Publications
Anatomy and Cell Biology Publications
Contrast Media & Molecular Imaging, Vol 2019 (2019)
Anatomy and Cell Biology Publications
Contrast Media & Molecular Imaging, Vol 2019 (2019)
Apoptosis is a feature of stroke and Alzheimer’s disease (AD), yet there is no accepted method to detect or follow apoptosis in the brain in vivo. We developed a bifunctional tracer [68Ga]Ga-TC3-OGDOTA containing a cell-penetrating peptide separate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f5648739cc0848378cdee9a1af6f3e
https://ir.lib.uwo.ca/biophysicspub/409
https://ir.lib.uwo.ca/biophysicspub/409
Autor:
Vilma R. Martins, Lisa Bertram, Neil R. Cashman, David Westaway, Katiane de Oliveira Pinto Coelho Nogueira, Flavio H. Beraldo, Valeriy G. Ostapchenko, Fabiana A. Caetano, Vania F. Prado, Marco A. M. Prado, Jerson L. Silva, Andre Luiz Sena Guimaraes, Nathalie Daude, Giulia D. S. Ferretti
Publikováno v:
Anatomy and Cell Biology Publications
The prion protein (PrPC) has been suggested to operate as a scaffold/receptor protein in neurons, participating in both physiological and pathological associated events. PrPC, laminin, and metabotropic glutamate receptor 5 (mGluR5) form a protein com
Autor:
Valeriy G, Ostapchenko, Jonatan, Snir, Mojmir, Suchy, Jue, Fan, M Rebecca, Cobb, Blaine A, Chronik, Michael, Kovacs, Vania F, Prado, Robert H E, Hudson, Stephen H, Pasternak, Marco A M, Prado, Robert, Bartha
Publikováno v:
Contrast Media & Molecular Imaging
Apoptosis is a feature of stroke and Alzheimer's disease (AD), yet there is no accepted method to detect or follow apoptosis in the brain in vivo. We developed a bifunctional tracer [68Ga]Ga-TC3-OGDOTA containing a cell-penetrating peptide separated