Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Valeriu, Damian"'
Autor:
Kylie A. Beattie, Meghna Verma, Richard J. Brennan, Diana Clausznitzer, Valeriu Damian, Derek Leishman, Mary E. Spilker, Britton Boras, Zhenhong Li, Elias Oziolor, Theodore R. Rieger, Anna Sher
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 12, Pp 2036-2051 (2024)
Abstract Quantitative systems toxicology (QST) models are increasingly being applied for predicting and understanding toxicity liabilities in pharmaceutical research and development. A European Federation of Pharmaceutical Industries and Associations
Externí odkaz:
https://doaj.org/article/a17a1566d5fd4e59a017f20987c31d4f
Autor:
Loveleena Bansal, Eva-Maria Nichols, Daniel P. Howsmon, Jessica Neisen, Christina M. Bessant, Fraser Cunningham, Sebastien Petit-Frere, Steve Ludbrook, Valeriu Damian
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Motivation: The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases. Nevertheless, very few
Externí odkaz:
https://doaj.org/article/af21613b5ce7409b84db7d116ea2d036
Autor:
Jason R. Chan, Richard Allen, Britton Boras, Antonio Cabal, Valeriu Damian, Francis D. Gibbons, Abhishek Gulati, Iraj Hosseini, Jeffrey D. Kearns, Ryuta Saito, Lourdes Cucurull-Sanchez, Jangir Selimkhanov, Andrew M. Stein, Kenichi Umehara, Guanyu Wang, Weirong Wang, Susana Neves-Zaph
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics.
Quantitative Systems Pharmacology (QSP) modeling is increasingly applied in the pharmaceutical industry to influence decision making across a wide range of stages from early discovery to clinical development to post-marketing activities. Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980e84f1c99e14567b1bde531244a584
https://pubmed.ncbi.nlm.nih.gov/35953664
https://pubmed.ncbi.nlm.nih.gov/35953664
Autor:
Brian J. Schmidt, Rajanikanth Madabushi, Piet H. van der Graaf, Kapil Gadkar, Cynthia J. Musante, Jane P. F. Bai, Mark Rogge, Kunal Naik, Justin C. Earp, Valeriu Damian, Christina Friedrich, Hao Zhu
Publikováno v:
The AAPS Journal. 23
The pharmaceutical industry is actively applying quantitative systems pharmacology (QSP) to make internal decisions and guide drug development. To facilitate the eventual development of a common framework for assessing the credibility of QSP models f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea692f642e7d6b7a150f8d9968884ae
https://doi.org/10.1208/s12248-021-00585-x
https://doi.org/10.1208/s12248-021-00585-x
Autor:
Jafar Sadik Shaik, Valeriu Damian, Katarzyna J. Macura, Susan L. Ford, Paul Galette, Kalpana Bakshi, Craig W. Hendrix, Michael A. Jacobs, Meiyappan Solaiyappan, Robert L. Janiczek, Sarah Lee, Manish Gupta, William Spreen, Beat M. Jucker, Edward J. Fuchs, Kelong Han, Ethel D. Weld, Parul Patel, Ronald D'Amico, David A. Margolis
Publikováno v:
British journal of clinical pharmacology. 88(4)
Aim Cabotegravir long-acting (LA) intramuscular (IM) injection is being investigated for HIV preexposure prophylaxis due to its potent antiretroviral activity and infrequent dosing requirement. A subset of healthy adult volunteers participating in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365905f764b24bf4cc0ca8430b97f6df
https://pubmed.ncbi.nlm.nih.gov/35350084
https://pubmed.ncbi.nlm.nih.gov/35350084
Autor:
Jane P F, Bai, Brian J, Schmidt, Kapil G, Gadkar, Valeriu, Damian, Justin C, Earp, Christina, Friedrich, Piet H, van der Graaf, Rajanikanth, Madabushi, Cynthia J, Musante, Kunal, Naik, Mark, Rogge, Hao, Zhu
Publikováno v:
The AAPS journal. 23(3)
The pharmaceutical industry is actively applying quantitative systems pharmacology (QSP) to make internal decisions and guide drug development. To facilitate the eventual development of a common framework for assessing the credibility of QSP models f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22fab0dfd22e794576cfee50b12fc8f9
https://pubmed.ncbi.nlm.nih.gov/33931790
https://pubmed.ncbi.nlm.nih.gov/33931790
Autor:
Majid Vakilynejad, Arijit Chakravarty, Tonika Bohnert, Anu Shilpa Krishnatry, Jerome T. Mettetal, Tristan S. Maurer, Christopher R. Gibson, Daniel R. Mudra, Edgar Schuck, Yaming Su, Marjoleen J.M.A Nijsen, Tycho Heimbach, Shining Wang, Virna J A Schuck, Cheng-Pang Hsu, Harvey Wong, Patrick Trapa, Joseph Raybon, Patricia Schroeder, Satyendra Suryawanshi, Jing Lin, Bianca M. Liederer, Valeriu Damian-Iordache, Alice Tsai
Publikováno v:
The AAPS Journal. 17:462-473
The application of modeling and simulation techniques is increasingly common in preclinical stages of the drug discovery and development process. A survey focusing on preclinical pharmacokinetic/pharmacodynamics (PK/PD) analysis was conducted across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987c55984d67b4b816af57121c982893
https://doi.org/10.1208/s12248-014-9716-2
https://doi.org/10.1208/s12248-014-9716-2
Autor:
Bao Hoang, Stephen C. Lenhard, Valeriu Damian, Hasan Alsaid, M. Reid Groseclose, Stephen Castellino, Beat M. Jucker, Gary D. Bowers, Mary V. Rambo, Manish Gupta, Fang Xie
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 268
Long-Acting Parenterals (LAPs) have been used in the clinic to provide sustained therapeutic drug levels at a target site, and thereby reducing the frequency of dosing required. In an effort to understand the factors associated with long-acting cabot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58d1430f17a0ba785ba00bc8e7649e0
https://pubmed.ncbi.nlm.nih.gov/29042321
https://pubmed.ncbi.nlm.nih.gov/29042321
Autor:
Ayşe, Ufuk, Frauke, Assmus, Laura, Francis, Jonathan, Plumb, Valeriu, Damian, Michael, Gertz, J Brian, Houston, Aleksandra, Galetin
Publikováno v:
Molecular pharmaceutics. 14(4)
Accumulation of respiratory drugs in human alveolar macrophages (AMs) has not been extensively studied in vitro and in silico despite its potential impact on therapeutic efficacy and/or occurrence of phospholipidosis. The current study aims to charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2e885c35cf62f600441d2c1caa64c97
https://pubmed.ncbi.nlm.nih.gov/28252969
https://pubmed.ncbi.nlm.nih.gov/28252969
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S88
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b175aa81a4828472b4e2e80f94e3202b
https://doi.org/10.1016/j.dmpk.2020.04.218
https://doi.org/10.1016/j.dmpk.2020.04.218