Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Valerio Mammoli"'
Autor:
Cecilia Baldassarri, Gianfabio Giorgioni, Alessandro Piergentili, Wilma Quaglia, Stefano Fontana, Valerio Mammoli, Gabriele Minazzato, Elisa Marangoni, Massimiliano Gasparrini, Leonardo Sorci, Nadia Raffaelli, Loredana Cappellacci, Riccardo Petrelli, Fabio Del Bello
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 189 (2023)
The prevention of nicotinamide adenine dinucleotide (NAD) biosynthesis is considered an attractive therapeutic approach against cancer, considering that tumor cells are characterized by an increased need for NAD to fuel their reprogrammed metabolism.
Externí odkaz:
https://doaj.org/article/23800b1cafb64571a44463c8a8295339
Autor:
Consuelo Amantini, Gianfabio Giorgioni, Alessandro Piergentili, Maria Beatrice Morelli, Valerio Mammoli, Bernhard Wünsch, Stefano Fontana, Carlo Santini, Wilma Quaglia, Alessandro Bonifazi, Massimo Nabissi, Dirk Schepmann, Mario Giannella, Fabio Del Bello, Cristina Cimarelli, Maura Pellei, Giorgio Santoni
[Image: see text] The potent N-methyl-d-aspartate (NMDA) receptor antagonists 1–3 have been demonstrated to show antiproliferative and cytotoxic effects in MCF-7 and SKBR3 breast cancer cell lines. To improve the knowledge about the role played by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af32d64a5581e0a31f2dd812d0cab477
https://europepmc.org/articles/PMC6466546/
https://europepmc.org/articles/PMC6466546/
Autor:
Alan L. Hudson, Alessandro Piergentili, Laura Mattioli, Corinne Dalila Paoletti, Maria Vittoria Micioni Di Bonaventura, Mario Giannella, Valerio Mammoli, Eleonora Diamanti, Maria Elena Giusepponi, Carlo Cifani, Fabio Del Bello, Wilma Quaglia, Maria Pigini
Publikováno v:
ACS Medicinal Chemistry Letters. 7:956-961
Tolerance and dependence associated with chronic opioid exposure result from molecular, cellular, and neural network adaptations. Such adaptations concern opioid and nonopioid systems, including α2-adrenoceptors (α2-ARs) and I1- and I2-imidazoline
Autor:
Alessandro Piergentili, Alessandro Bonifazi, Diego Dal Ben, Ajiroghene Thomas, Sergi Ferré, Maria Pigini, Gianfabio Giorgioni, Mario Giannella, Fabio Del Bello, Wilma Quaglia, Thomas M. Keck, Valerio Mammoli, Marta Sánchez-Soto, Amy Hauck Newman
Publikováno v:
ChemMedChem. 11:1819-1828
Over the year, the 2-substituted imidazoline nucleus has been demonstrated to be a bioversatile structural motif. In this study, novel imidazoline derivatives, bearing a 3- and/or 4-hydroxy- or methoxy-substituted phenyl ring linked by an ethylene br
Autor:
Fabio, Del Bello, Alessandro, Bonifazi, Gianfabio, Giorgioni, Carlo, Cifani, Maria Vittoria, Micioni Di Bonaventura, Riccardo, Petrelli, Alessandro, Piergentili, Stefano, Fontana, Valerio, Mammoli, Hideaki, Yano, Rosanna, Matucci, Giulio, Vistoli, Wilma, Quaglia
Publikováno v:
Journal of medicinal chemistry. 61(8)
In the present article, the M
Autor:
Fabio Del Bello, Maria Vittoria Micioni Di Bonaventura, Alessandro Piergentili, Valerio Mammoli, Alessandro Bonifazi, Giulio Vistoli, Hideaki Yano, Carlo Cifani, Rosanna Matucci, Stefano Fontana, Riccardo Petrelli, Wilma Quaglia, Gianfabio Giorgioni
In the present article, the M1 mAChR bitopic agonist 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1, 1) has been demonstrated to show unexpected D4R selectivity over D2R and D3R and to behave as a D4R antagonist. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a12bc5f2cf12852b92c6e3eaac2f0c
http://hdl.handle.net/11581/408263
http://hdl.handle.net/11581/408263
Autor:
Massimo Nabissi, Maura Pellei, Wilma Quaglia, Cristina Cimarelli, Alessandro Bonifazi, Dirk Schepmann, Riccardo Petrelli, Alessandro Piergentili, Consuelo Amantini, Valerio Mammoli, Giulio Vistoli, Fabio Del Bello, Bernhard Wünsch, Elisabetta Barocelli, Giorgio Santoni, Lisa Flammini, Simona Bertoni
Publikováno v:
Journal of Medicinal Chemistry. 58:8601-8615
Two series of 1,4-dioxanes (4-11 and 12-19) were rationally designed and prepared to interact either with the phencyclidine (PCP) binding site of the N-methyl-d-aspartate (NMDA) receptor or with σ1 receptors, respectively. The biological profiles of
Autor:
Fabio, Del Bello, Antonio, Cilia, Antonio, Carrieri, Domenico Claudio, Fasano, Carla, Ghelardini, Lorenzo, Di Cesare Mannelli, Laura, Micheli, Carlo, Santini, Eleonora, Diamanti, Mario, Giannella, Gianfabio, Giorgioni, Valerio, Mammoli, Corinne Dalila, Paoletti, Riccardo, Petrelli, Alessandro, Piergentili, Wilma, Quaglia, Maria, Pigini
Publikováno v:
ChemMedChem. 11(20)
The involvement of the serotonin 5-HT
Autor:
Antonio Cilia, Wilma Quaglia, Corinne Dalila Paoletti, Maria Pigini, Domenico Claudio Fasano, Eleonora Diamanti, Gianfabio Giorgioni, Lorenzo Di Cesare Mannelli, Carlo Santini, Alessandro Piergentili, Mario Giannella, Antonio Carrieri, Laura Micheli, Fabio Del Bello, Valerio Mammoli, Riccardo Petrelli, Carla Ghelardini
The involvement of the serotonin 5-HT1A receptor (5-HT1A-R) in the antidepressant effect of allyphenyline and its analogues indicates that ligands bearing the 2-substituted imidazoline nucleus as a structural motif interact with 5-HT1A-R. Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4d91e2f2169006bb8d22d927c2dcc9
http://hdl.handle.net/2158/1060679
http://hdl.handle.net/2158/1060679
Autor:
Laura Mattioli, Valerio Mammoli, Marina Perfumi, Alessandro Bonifazi, Federica Titomanlio, Mario Giannella, Eleonora Diamanti, Maria Pigini, Wilma Quaglia, Alessandro Piergentili, Al Hudson, Fabio Del Bello
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:2259-2265
Aim of the present study was to obtain novel α2-adrenoreceptor (α2-AR) antagonists, possibly endowed with subtype-selectivity. Therefore, inspired by the non subtype-selective α2-AR antagonist idazoxan, we designed 1,4-dioxane derivatives bearing