Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Valerio Consalvi"'
Autor:
Maria Petrosino, Leonore Novak, Alessandra Pasquo, Paola Turina, Emidio Capriotti, Velia Minicozzi, Valerio Consalvi, Roberta Chiaraluce
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-23 (2023)
Abstract Mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3), also called extracellular regulated kinases (ERK2 and ERK1), are serine/threonine kinase activated downstream by the Ras/Raf/MEK/ERK signal transduction cascade that regulates a va
Externí odkaz:
https://doaj.org/article/629e896713a64b7e8fe68e4a682f963a
Autor:
Tiziana Sanavia, Paola Turina, Silvia Morante, Valerio Consalvi, Arthur M. Lesk, Constantina Bakolitsa, Daniele Dell'Orco
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/c72a524a5e7f42f485febcbd61f0b19a
Autor:
Tecla Ciociola, Laura Giovati, Tiziano De Simone, Greta Bergamaschi, Alessandro Gori, Valerio Consalvi, Stefania Conti, Alberto Vitali
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 472 (2023)
Antimicrobial resistance is a major public health concern worldwide. Albeit to a lesser extent than bacteria, fungi are also becoming increasingly resistant to antifungal drugs. Moreover, due to the small number of antifungal classes, therapy options
Externí odkaz:
https://doaj.org/article/743c7a4a71804ef58e96b37731350c60
Autor:
Maria Petrosino, Leonore Novak, Alessandra Pasquo, Roberta Chiaraluce, Paola Turina, Emidio Capriotti, Valerio Consalvi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5416 (2021)
Large scale genome sequencing allowed the identification of a massive number of genetic variations, whose impact on human health is still unknown. In this review we analyze, by an in silico-based strategy, the impact of missense variants on cancer-re
Externí odkaz:
https://doaj.org/article/5a0b3dd509aa49b68568b223c8072a6f
Autor:
Leonore Novak, Maria Petrosino, Daniele Santorelli, Roberta Chiaraluce, Valerio Consalvi, Alessandra Pasquo, Carlo Travaglini-Allocatelli
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5953 (2021)
Bromodomains (BRDs) are small protein interaction modules of about 110 amino acids that selectively recognize acetylated lysine in histones and other proteins. These domains have been identified in a variety of multi-domain proteins involved in trans
Externí odkaz:
https://doaj.org/article/928f6a43d5b34ed1a594a86fde683c64
Autor:
Maria Petrosino, Daniela Bonetti, Alessandra Pasquo, Laura Lori, Roberta Chiaraluce, Valerio Consalvi, Carlo Travaglini-Allocatelli
Publikováno v:
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 99-104 (2017)
Bromodomains (BRDs) are small protein domains often present in large multidomain proteins involved in transcriptional regulation in eukaryotic cells. They currently represent valuable targets for the development of inhibitors of aberrant transcriptio
Externí odkaz:
https://doaj.org/article/7301862b8af74c558bcd25801b07fa67
Autor:
Annarita Fiorillo, Maria Petrosino, Andrea Ilari, Alessandra Pasquo, Alessandra Cipollone, Maristella Maggi, Roberta Chiaraluce, Valerio Consalvi
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199191 (2018)
Cancer cells are able to survive in difficult conditions, reprogramming their metabolism according to their requirements. Under hypoxic conditions they shift from oxidative phosphorylation to aerobic glycolysis, a behavior known as Warburg effect. In
Externí odkaz:
https://doaj.org/article/aea6a3fc775d4c81a31610ead4b83318
Autor:
Laura Lori, Alessandra Pasquo, Clorinda Lori, Maria Petrosino, Roberta Chiaraluce, Cynthia Tallant, Stefan Knapp, Valerio Consalvi
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159180 (2016)
Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequ
Externí odkaz:
https://doaj.org/article/5e875bb8a65640469c42b71ff9d1f5c7
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 2, Pp 1314-1326 (2012)
Serine hydroxymethyltransferase from the psychrophilic microorganism Psychromonas ingrahamii was expressed in Escherichia coli and purified as a His-tag fusion protein. The enzyme was characterized with respect to its spectroscopic, catalytic, and th
Externí odkaz:
https://doaj.org/article/b81c8f58088a4adab9bcc9a6257ecfa7
Autor:
Anna Scotto D’Abusco, Rita Casadio, Gianluca Tasco, Laura Giangiacomo, Anna Giartosio, Valentina Calamia, Stefania Di Marco, Roberta Chiaraluce, Valerio Consalvi, Roberto Scandurra, Laura Politi
Publikováno v:
Archaea, Vol 1, Iss 6, Pp 411-423 (2005)
The recombinant amidase from the hyperthermophylic archaeon Sulfolobus solfataricus (SSAM) a signature amidase, was cloned, purified and characterized. The enzyme is active on a large number of aliphatic and aromatic amides over the temperature range
Externí odkaz:
https://doaj.org/article/aa02c13a3f2c407f98f2e4c4447655ab