Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Valerio Bianchi"'
Autor:
Bas Castelijns, Mirna L. Baak, Ilia S. Timpanaro, Caroline R. M. Wiggers, Marit W. Vermunt, Peng Shang, Ivanela Kondova, Geert Geeven, Valerio Bianchi, Wouter de Laat, Niels Geijsen, Menno P. Creyghton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The understanding of the changes regulating gene expression relevant for the emergence of the human brain and its susceptibility to disease is limited. Here, the authors identified a set of regulatory elements that evolved in hominins affecting oligo
Externí odkaz:
https://doaj.org/article/82266434e4204259b6a7fa449dc212bd
Autor:
Joyce C. K. Man, Rajiv A. Mohan, Malou van den Boogaard, Catharina R. E. Hilvering, Catherine Jenkins, Vincent Wakker, Valerio Bianchi, Wouter de Laat, Phil Barnett, Bastiaan J. Boukens, Vincent M. Christoffels
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Mutations associated with SCN5A, which encodes the major cardiac sodium channel, influence impulse conduction and are associated with arrhythmia disorders. Here, the authors identify an evolutionary conserved, super enhancer-like, regulatory cluster
Externí odkaz:
https://doaj.org/article/cb64f996f52046f4a1729c8c928335c9
Autor:
Xinan H Yang, Rangarajan D Nadadur, Catharina RE Hilvering, Valerio Bianchi, Michael Werner, Stefan R Mazurek, Margaret Gadek, Kaitlyn M Shen, Joseph Aaron Goldman, Leonid Tyan, Jenna Bekeny, Johnathon M Hall, Nutishia Lee, Carlos Perez-Cervantes, Ozanna Burnicka-Turek, Kenneth D Poss, Christopher R Weber, Wouter de Laat, Alexander J Ruthenburg, Ivan P Moskowitz
Publikováno v:
eLife, Vol 6 (2017)
The noncoding genome is pervasively transcribed. Noncoding RNAs (ncRNAs) generated from enhancers have been proposed as a general facet of enhancer function and some have been shown to be required for enhancer activity. Here we examine the transcript
Externí odkaz:
https://doaj.org/article/483cf25f032e4eb3bd37b9b1b0cee643
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
MycVD induces proliferation to a similar extend as MycWT but is impaired in cellular transformation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a5dc71a4a60e365841b123aad69483
https://doi.org/10.1158/0008-5472.22411665
https://doi.org/10.1158/0008-5472.22411665
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38feb1aa6ffa33436fa76ac071ae6bf8
https://doi.org/10.1158/0008-5472.22411650
https://doi.org/10.1158/0008-5472.22411650
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
MycVD-sensitive genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0928aa0812ebd595332856a69dd4d82d
https://doi.org/10.1158/0008-5472.22411641.v1
https://doi.org/10.1158/0008-5472.22411641.v1
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
Legend for Supplementary Figures S1-S6 and Supplementary Table S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ff26cb043780fc143cdd341ecb841f
https://doi.org/10.1158/0008-5472.22411653
https://doi.org/10.1158/0008-5472.22411653
Data from Identification of MYC-Dependent Transcriptional Programs in Oncogene-Addicted Liver Tumors
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
Tumors driven by activation of the transcription factor MYC generally show oncogene addiction. However, the gene expression programs that depend upon sustained MYC activity remain unknown. In this study, we employed a mouse model of liver carcinoma d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f64b4c3bfd8c50d38726216ba301076
https://doi.org/10.1158/0008-5472.c.6508269.v1
https://doi.org/10.1158/0008-5472.c.6508269.v1
Autor:
Zachary A. Kadow, Nathan R. Tucker, Wouter de Laat, Antoinette F. van Ouwerkerk, Paulus Kirchhof, Valerio Bianchi, Fernanda M Bosada, Vincent M. Christoffels, James F. Martin, Rangarajan D. Nadadur, Larissa Fabritz, Jasmeet S. Reyat, Ivan P. Moskowitz, Amelia W. Hall, Sonja Lazarevic, Patrick T. Ellinor
Publikováno v:
Circulation research, 127(1), 34-50. Lippincott Williams and Wilkins
Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, an
Autor:
Wouter de Laat, Carolina Roselli, Geert Geeven, Honghuang Lin, Valerio Bianchi, Amelia W. Hall, Patrick T. Ellinor, Steven A. Lubitz, Kenneth Bedi, Nathan R. Tucker, Kenneth B. Margulies, Mark Chaffin
Publikováno v:
Circ Genom Precis Med
Circulation: Genomic and precision medicine, 13(6)
Circulation: Genomic and precision medicine, 13(6)
Background: Atrial fibrillation (AF) often arises from structural abnormalities in the left atria (LA). Annotation of the noncoding genome in human LA is limited, as are effects on gene expression and chromatin architecture. Many AF-associated geneti