Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Valerie Vivat Hannah"'
Autor:
Wibke E. Diederich, Robert Meinecke, Astrid Sitte, Lars Neumann, Valerie Vivat-Hannah, Cédric Atmanene, Helene Köster, Maren Kuhnert, Nedyalka Radeva, Dominique Roecklin, Timo Krotzky, Markus Zeeb, Andreas Heine, Jean‐Paul Renaud, Franziska Popp, Alexander Metz, J. Schiebel, Gerhard Klebe, Nina Schlinck
Publikováno v:
ChemMedChem. 10(9)
Fragment-based lead discovery is gaining momentum in drug development. Typically, a hierarchical cascade of several screening techniques is consulted to identify fragment hits which are then analyzed by crystallography. Because crystal structures wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b957724d456a4db52d08a4423c3c9d3
https://pubmed.ncbi.nlm.nih.gov/26259992
https://pubmed.ncbi.nlm.nih.gov/26259992
Publikováno v:
Drug Discovery Today. 7:1165-1174
Natural and synthetic retinoids are effective inhibitors of tumor cell growth in vitro and in vivo. However, the toxicity of natural derivatives of vitamin A limits their therapeutic use. Recently, synthetic compounds selective for the different reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b77c4e9f4710e0c8cac8846f4f3717
https://doi.org/10.1016/s1359-6446(02)02526-6
https://doi.org/10.1016/s1359-6446(02)02526-6
Autor:
Cédric Atmanene, Denis Zeyer, A Van Dorsselaer, Valerie Vivat Hannah, Sarah Sanglier-Cianférani
Publikováno v:
Future medicinal chemistry. 2(1)
The success of early drug-discovery programs depends on the adequate combination of complementary and orthogonal technologies allowing hit/lead compounds to be optimized and improve therapeutic activity. Among the available biophysical methods, nativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f56186924f58e3f27a9ebb421d950a
https://pubmed.ncbi.nlm.nih.gov/21426045
https://pubmed.ncbi.nlm.nih.gov/21426045
Autor:
Dominique Roecklin, Albane le Maire, Marina Grimaldi, Sonia Dagnino, Patrick Balaguer, Valerie Vivat-Hannah, William Bourguet
Publikováno v:
EMBO Reports
EMBO Reports, EMBO Press, 2009, 10 (4), pp.367-73. ⟨10.1038/embor.2009.8⟩
EMBO Reports, 2009, 10 (4), pp.367-73. ⟨10.1038/embor.2009.8⟩
EMBO Reports, EMBO Press, 2009, 10 (4), pp.367-73. ⟨10.1038/embor.2009.8⟩
EMBO Reports, 2009, 10 (4), pp.367-73. ⟨10.1038/embor.2009.8⟩
International audience; The nuclear receptor retinoid X receptor-alpha (RXR-alpha)-peroxisome proliferator-activated receptor-gamma (PPAR-gamma) heterodimer was recently reported to have a crucial function in mediating the deleterious effects of orga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6b49af0b58e450778e44a0d1eda5e4
https://www.hal.inserm.fr/inserm-00375675/document
https://www.hal.inserm.fr/inserm-00375675/document
Autor:
Valerie Vivat-Hannah, William Bourguet, Catherine A. Royer, Vivian Pogenberg, Pierre Germain, Hinrich Gronemeyer, Angel R. de Lera, Jean-François Guichou, Sabrina Kammerer, Efrén Pérez
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (2), pp.1625-33. ⟨10.1074/jbc.M409302200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (2), pp.1625-33. ⟨10.1074/jbc.M409302200⟩
International audience; Retinoid receptors (RARs and RXRs) are ligand-activated transcription factors that regulate the transcription of target genes by recruiting coregulator complexes at cognate promoters. To understand the effects of heterodimeriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3dd9a02f6031fa98a34f0e7b5276e0a
https://hal.archives-ouvertes.fr/hal-00187727
https://hal.archives-ouvertes.fr/hal-00187727
As a promiscuous dimerization partner the retinoid X receptor (RXR) can contribute to signaling by multiple nuclear receptors. However, the impact of RXR cosignaling and the possible existence of an RXR homodimer signaling pathway are largely unexplo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41df9e15f2f52bf5e1e2822e30048c45
https://europepmc.org/articles/PMC207639/
https://europepmc.org/articles/PMC207639/