Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation.

Autor: Emma M Quinn, Ciara Coleman, Ben Molloy, Patricia Dominguez Castro, Paul Cormican, Valerie Trimble, Nasir Mahmud, Ross McManus

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140049 (2015)

Genetic studies have to date identified 43 genome wide significant coeliac disease susceptibility (CD) loci comprising over 70 candidate genes. However, how altered regulation of such disease associated genes contributes to CD pathogenesis remains to

Externí odkaz: https://doaj.org/article/890b5762f48f49e89869b9ce4cd4095e

Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci

Autor: Gary Donohoe, Gosia Trynka, Cisca Wijmenga, Anthony W. Ryan, Nicholas P. Kennedy, Derek W. Morris, Dermot Kelleher, Nasir Mahmud, Colm O'Morain, Clifford Kiat, Ciara Coleman, Emma M. Quinn, Ross McManus, Padraic MacMathuna, Valerie Trimble, Judith Conroy, Sean Ennis, Aiden Corvin, Richard Anney, Valerie Byrnes

Publikováno v: European Journal of Human Genetics, 24, 291-297. Nature Publishing Group
European Journal of Human Genetics

Coeliac disease (CD) is a chronic immune-mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Specific HLA-DQA1 and HLA-DQB1 alleles are established coeliac susceptibility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6a740c2313e220ce0941e7deaafe2c
https://research.rug.nl/en/publications/e9e81744-0135-467c-a996-20137842c659

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappa B signalling

Autor: Donatella Barisani, Chris J. J. Mulder, Graham A. Heap, M.L. Mearin, Jihane Romanos, Cisca Wijmenga, Fiona M. Stevens, Gosia Trynka, Marcel Bruinenberg, David S Sanders, Graham Turner, Peter D. Howdle, Valerie Trimble, D A van Heel, Lude Franke, Wieke H. M. Verbeek, Dermot Kelleher, Alexandra Zhernakova, C. G. F. de Kovel, Karen A. Hunt, Geoffrey Holmes, Ross McManus, Julian R.F. Walters, Anthony W. Ryan, Maria Teresa Bardella, Mathieu Platteel

Publikováno v: Gut, 58(8), 1078-1083. BMJ PUBLISHING GROUP
Gut, 58(8), 1078-1083. BMJ Publishing Group
Trynka, G, Zhernakova, A, Romanos, J, Franke, L, Hunt, K A, Turner, G A, Bruinenberg, M, Heap, G A, Platteel, M, Ryan, A, de Kovel, C, Holmes, G K, Howdle, P D, Walters, J R, Sanders, D S, Mulder, C J J, Mearin, M L, Verbeek, W H M, Trimble, V, Stevens, F M, Kelleher, D, Barisani, D, Bardella, M T, McManus, R, van Heel, D A & Wijmenga, C 2009, ' Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling ', Gut, vol. 58, no. 8, pp. 1078-1083 . https://doi.org/10.1136/gut.2008.169052

Objective: Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci, we selected 458 single nucleotide p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0a9a47ea484a5fd189881669ead05c
https://research.rug.nl/en/publications/b6294c0a-13e6-4178-902b-0f5cb27ab25d

Newly identified genetic risk variants for celiac disease related to the immune response

Autor: Ross McManus, Julian R.F. Walters, M. Luisa Mearin, Daniel J. Pennington, Fiona M. Stevens, Martin C. Wapenaar, Davinder Panesar, Graham A. Heap, Chris J. J. Mulder, Peter D. Howdle, Dermot Kelleher, Alexandra Zhernakova, Geoffrey Holmes, Raymond J. Playford, Gosia Trynka, Rhian Gwilliam, David A. van Heel, Wieke H. M. Verbeek, William M. McLaren, Karen A. Hunt, Wendy L. McArdle, Panos Deloukas, Lotte C. Dinesen, Ralph McGinnis, Graham Turner, Cisca Wijmenga, Lude Franke, Colm O'Morain, Fumihiko Takeuchi, Marcel Bruinenberg, David S Sanders, David P. Strachan, Nicholas P. Kennedy, Anthony W. Ryan, Charles A. Mein, Jihane Romanos, Valerie Trimble

Publikováno v: Hunt, K A, Zhernakova, A, Turner, G, Heap, G A, Franke, L, Bruinenberg, M, Romanos, J, Dinesen, L C, Ryan, A W, Panesar, D, Gwilliam, R, Takeuchi, F, McLaren, W M, Holmes, G K, Howdle, P D, Walters, J R, Sanders, D S, Playford, R J, Trynka, G, Mulder, C J J, Mearin, M L, Verbeek, W H M, Trimble, V, Stevens, F M, O'Morain, C, Kennedy, N P, Kelleher, D, Pennington, D J, Strachan, D P, McArdle, W L, Mein, C A, Wapenaar, MC, Deloukas, P, McGinnis, R, McManus, R, Wijmenga, C & van Heel, D A 2008, ' Newly identified genetic risk variants for celiac disease related to the immune response ', Nature Genetics, vol. 40, no. 4, pp. 395-402 . https://doi.org/10.1038/ng.102
Nature Genetics, 40(4), 395-402. Nature Publishing Group

PUBLISHED
* Joint Senior Authors
We acknowledge funding from Coeliac UK (to DAvH); the Coeliac Disease Consortium (an innovative cluster approved by the Netherlands Genomics Initiative and partly funded by the Dutch Government, grant BSIK03

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f859d1a23a98a236f242c8c5dea96a
https://doi.org/10.1038/ng.102

Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study

Autor: Graham Turner, Brian J. Egan, Nicholas P. Kennedy, Eimear Close, Anthony W. Ryan, Colm O'Morain, Ross McManus, Kunal D Patel, Conleth Feighery, Garrett Lawlor, Karen Brophy, Valerie Trimble, Dermot Kelleher, Fiona M. Stevens, Mohamed Abuzakouk, Padraic MacMathuna

Publikováno v: BMC Medical Genetics
BMC Medical Genetics, Vol 11, Iss 1, p 76 (2010)

Background Recent whole genome analysis and follow-up studies have identified many new risk variants for coeliac disease (CD, gluten intolerance). The majority of newly associated regions encode candidate genes with a clear functional role in T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c0b31b39853f894f7a19c0a99798f7
https://doi.org/10.1186/1471-2350-11-76