Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Valerie Sabourin"'
Autor:
Marco Biondini, Camille Lehuédé, Sébastien Tabariès, Matthew G. Annis, Alain Pacis, Eric H. Ma, Christine Tam, Brian E. Hsu, Yannick Audet-Delage, Afnan Abu-Thuraia, Charlotte Girondel, Valerie Sabourin, Stephanie P. Totten, Mariana de Sá Tavares Russo, Gaëlle Bridon, Daina Avizonis, Marie-Christine Guiot, Julie St-Pierre, Josie Ursini-Siegel, Russell Jones, Peter M. Siegel
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103276- (2024)
Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet little is known regarding how cancer cells modify their acquired metabolic programs in response to different metastatic microenvironments. We have previously
Externí odkaz:
https://doaj.org/article/9541bdda466b464aac43f308bd0b1d8e
Autor:
Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline R. Ha, Elena Voorand, Matthew G. Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel La Selva, Sébastien Tabariès, Brian E. Hsu, Matthew J. Siegel, Matthew Dankner, Eduardo Cepeda Canedo, Mathieu Lajoie, Ian R. Watson, Claire M. Brown, Peter M. Siegel, Josie Ursini-Siegel
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Abstract Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate
Externí odkaz:
https://doaj.org/article/3438a5e4c9ae4d46bf14a48ac898942d
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
Supplementary Figure Legends, Figures 1 - 7 from Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee845bd9026f86008b686e96ad6b99
https://doi.org/10.1158/1541-7786.22515571.v1
https://doi.org/10.1158/1541-7786.22515571.v1
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1b890a55ac69f6fffa4d137ea60e32
https://doi.org/10.1158/1541-7786.c.6541126
https://doi.org/10.1158/1541-7786.c.6541126
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
Supplementary Table 1: List of differentially expressed genes comprising the ShcA-PTBMUT-like gene signature (GEO GSE41718) used for Figure S7. Supplementary Table 2: Antibodies used for immunoblot analysis (referred to in the supplementary methods).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131531661948e8598188b2837b8798c6
https://doi.org/10.1158/1541-7786.22515565.v1
https://doi.org/10.1158/1541-7786.22515565.v1
Autor:
Josie Ursini-Siegel, William J. Muller, Claudia L. Kleinman, Young Kyuen Im, Eduardo Cepeda Cañedo, Steven Hébert, Valerie Sabourin, Harvey W. Smith, Ryuhjin Ahn, Jacqueline R. Ha
Experimental methods for Crispr/Cas9 genomic editing, BioID, immunoblot analysis, immunoprecipitation analysis, immunohistochemistry and bioinformatics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001c339cde24411ea5fb922f61d553f7
https://doi.org/10.1158/1541-7786.22515568
https://doi.org/10.1158/1541-7786.22515568
Autor:
Steven Hébert, Ryuhjin Ahn, Ivan Topisirovic, Matthew Dankner, Daina Avizonis, Kyle Lewis, Julie St-Pierre, Marie-Line Goulet, Josie Ursini-Siegel, Eduardo Cepeda Cañedo, Mark Basik, Alice Nguyen, Kevin Petrecca, Valerie Sabourin, Nancy Santos Martínez, Constanza Martinez, Benjamin Lebeau, Rongtuan Lin, Morag Park, Ouafa Najyb, Adriana Aguilar-Mahecha, Michael Witcher, Peter M. Siegel, Paul Savage, Catherine Chabot, Rachel La Selva, Young Kyuen Im, Claudia L. Kleinman, Hellen Kuasne, Stephanie Totten, Michael Pollak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Bioenergetic perturbations driving neoplastic growth increase the production of reactive oxygen species (ROS), requiring a compensatory increase in ROS scavengers to limit oxidative stress. Intervention strategies that simultaneously induce energetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efb52addcc93ac7072fb39e5c81282a
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
Autor:
Mathieu Lajoie, Ryuhjin Ahn, Jesse Hudson, Ian R. Watson, Sébastien Tabariès, Peter M. Siegel, Eduardo Cepeda Cañedo, Rachel La Selva, Claire M. Brown, Julien Senecal, Valerie Sabourin, Josie Ursini-Siegel, Matthew J. Siegel, Elena Voorand, Brian E. Hsu, Matthew Dankner, Alex Kiepas, Kyle Lewis, Jacqueline R. Ha, Matthew G. Annis
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f1f183a688a8be5016364492f4c75
https://doi.org/10.1186/s13058-020-1245-6
https://doi.org/10.1186/s13058-020-1245-6
Autor:
John Heath, Stephanie Totten, Young Kyuen Im, Valerie Sabourin, Kathryn Hunt, Josie Ursini-Siegel
Publikováno v:
Cancer Immunology Research. 10:P014-P014
The tumor microenvironment (TME) is a complex arms race composed of host stroma and rapidly adapting cancer cells. This symbiosis is further complicated when dissecting the influence of inflammation, due to its multifaceted function within the TME as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2804972230eb50ef35226e2d58bbb83e
https://doi.org/10.1158/2326-6074.tumimm21-p014
https://doi.org/10.1158/2326-6074.tumimm21-p014
Autor:
Harvey W. Smith, Valerie Sabourin, Jacqueline R. Ha, Josie Ursini-Siegel, Claudia L. Kleinman, Ryuhjin Ahn, Steven Hébert, Young Kyuen Im, Eduardo Cepeda Cañedo, William J. Muller
Publikováno v:
Molecular Cancer Research. 16:894-908
The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f58132846de8d86b4f2c68f476962b
https://doi.org/10.1158/1541-7786.mcr-17-0623
https://doi.org/10.1158/1541-7786.mcr-17-0623