Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Valerie Rezek"'
Autor:
Wenli Mu, Valerie Rezek, Heather Martin, Mayra A. Carrillo, Shallu Tomer, Philip Hamid, Miguel A. Lizarraga, Tristan D. Tibbe, Otto O. Yang, Beth D. Jamieson, Scott G. Kitchen, Anjie Zhen
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
A hallmark of HIV-1 infection is chronic inflammation, even in patients treated with antiretroviral therapy (ART). Chronic inflammation drives HIV-1 pathogenesis, leading to loss of CD4+ T cells and exhaustion of antiviral immunity. Therefore, strate
Externí odkaz:
https://doaj.org/article/ccbac288cbda4f758e65fea1428803d6
Autor:
Shallu Tomer, Wenli Mu, Gajendra Suryawanshi, Hwee Ng, Li Wang, Wally Wennerberg, Valerie Rezek, Heather Martin, Irvin Chen, Scott Kitchen, Anjie Zhen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cannabis (Cannabis sativa) is a widely used drug in the United States and the frequency of cannabis use is particularly high among people living with HIV (PLWH). One key component of cannabis, the non-psychotropic (−)-cannabidiol (CBD) exerts a wid
Externí odkaz:
https://doaj.org/article/f92e90ed1c9249fcb83d60a6690acfbe
Autor:
Evan R. Abt, Khalid Rashid, Thuc M. Le, Suwen Li, Hailey R. Lee, Vincent Lok, Luyi Li, Amanda L. Creech, Amanda N. Labora, Hanna K. Mandl, Alex K. Lam, Arthur Cho, Valerie Rezek, Nanping Wu, Gabriel Abril-Rodriguez, Ethan W. Rosser, Steven D. Mittelman, Willy Hugo, Thomas Mehrling, Shanta Bantia, Antoni Ribas, Timothy R. Donahue, Gay M. Crooks, Ting-Ting Wu, Caius G. Radu
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is inc
Externí odkaz:
https://doaj.org/article/e438254920ee4e73ba0fa35c8e36bf84
Autor:
Maria Daskou, William Mu, Madhav Sharma, Hariclea Vasilopoulos, Rachel Heymans, Eleni Ritou, Valerie Rezek, Philip Hamid, Athanasios Kossyvakis, Shubhendu Sen Roy, Victor Grijalva, Arnab Chattopadhyay, Scott G. Kitchen, Alan M. Fogelman, Srinivasa T. Reddy, Theodoros Kelesidis
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1 (2022)
Novel therapeutic strategies are needed to attenuate increased systemic and gut inflammation that contribute to morbidity and mortality in chronic HIV infection despite potent antiretroviral therapy (ART). The goal of this study is to use preclinical
Externí odkaz:
https://doaj.org/article/86c8fa7801b54de1b999098a4c5d396c
Autor:
Anjie Zhen, Mayra A Carrillo, Wenli Mu, Valerie Rezek, Heather Martin, Philip Hamid, Irvin S Y Chen, Otto O Yang, Jerome A Zack, Scott G Kitchen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009895 (2021)
[This corrects the article DOI: 10.1371/journal.ppat.1009404.].
Externí odkaz:
https://doaj.org/article/918d89716afc466986f990abb5a59a66
Autor:
Anjie Zhen, Mayra A Carrillo, Wenli Mu, Valerie Rezek, Heather Martin, Philip Hamid, Irvin S Y Chen, Otto O Yang, Jerome A Zack, Scott G Kitchen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009404 (2021)
Due to the durability and persistence of reservoirs of HIV-1-infected cells, combination antiretroviral therapy (ART) is insufficient in eradicating infection. Achieving HIV-1 cure or sustained remission without ART treatment will require the enhance
Externí odkaz:
https://doaj.org/article/faeeeee9e47a4f8c816035cdbb51a600
Autor:
Bryan P Burke, Bernard R Levin, Jane Zhang, Anna Sahakyan, Joshua Boyer, Maria V Carroll, Joanna Camba Colón, Naomi Keech, Valerie Rezek, Gregory Bristol, Erica Eggers, Ruth Cortado, Maureen P Boyd, Helen Impey, Saki Shimizu, Emily L Lowe, Gene-Errol E Ringpis, Sohn G Kim, Dimitrios N Vatakis, Louis R Breton, Jeffrey S Bartlett, Irvin S Y Chen, Scott G Kitchen, Dong Sung An, Geoff P Symonds
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
We described earlier a dual-combination anti-HIV type 1 (HIV-1) lentiviral vector (LVsh5/C46) that downregulates CCR5 expression of transduced cells via RNAi and inhibits HIV-1 fusion via cell surface expression of cell membrane-anchored C46 antivira
Externí odkaz:
https://doaj.org/article/3e5b33d836f143b2a0a873b4e9851286
Autor:
Scott G Kitchen, Bernard R Levin, Gregory Bristol, Valerie Rezek, Sohn Kim, Christian Aguilera-Sandoval, Arumugam Balamurugan, Otto O Yang, Jerome A Zack
Publikováno v:
PLoS Pathogens, Vol 8, Iss 4, p e1002649 (2012)
The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling viral replication in vivo, but ultimately fails in its ability to eradicate the virus. Our intent in these studies is to develop ways to enhance and restore
Externí odkaz:
https://doaj.org/article/7752c31cf1ae480caa5bf4859d5d0f09
Mitoquinone mesylate attenuates brain inflammation in humanized mouse model of chronic HIV infection
Autor:
Sandro Satta, Cristelle Hugo, Madhav Sharma, Valerie Rezek, Athanassios Kossyvakis, Shubhendu Sen Roy, Scott Kitchen, Theodoros Kelesidis
Publikováno v:
AIDS. 36:1609-1611
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8888160e4f6dfc90c1d23a0c2e90681
https://doi.org/10.1097/qad.0000000000003291
https://doi.org/10.1097/qad.0000000000003291
Autor:
Scott Kitchen, Miguel Lizarraga, Heather Martin, Valerie Rezek, Mayra A. Carrillo, Anjie Zhen, Wenli Mu
Publikováno v:
Journal of visualized experiments : JoVE. (188)
The human immunodeficiency virus (HIV-1) pandemic continues to spread unabated worldwide, and currently, there is no vaccine available against HIV. Although combinational antiretroviral therapy (cART) has been successful in suppressing viral replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d206b57338013376832b5def4c4e7fbc
https://pubmed.ncbi.nlm.nih.gov/36282697
https://pubmed.ncbi.nlm.nih.gov/36282697