Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Valerie O'Donnell"'
Autor:
Phillip M. Brailey, Lauren Evans, Juan Carlos López-Rodríguez, Anthony Sinadinos, Victoria Tyrrel, Gavin Kelly, Valerie O’Donnell, Peter Ghazal, Susan John, Patricia Barral
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Modulation of metabolic pathways is linked to regulation of immune cells including macrophages. Here the authors identify a role for CD1d in the metabolic rewiring of macrophages, which alters responsiveness to innate stimuli.
Externí odkaz:
https://doaj.org/article/7fbedabfbd094fb7873e3dad81a05d67
Autor:
Richard Skone, Daniel White, Bethan Phillips, Jennifer Evans, Robert Andrews, Benjamin Saunders, Kerry Hood, Mallinath Chakraborty, Sarah Edkins, Barbara Paquete, Sian Foulkes, Anna Barrow, Siske Struik, Valerie O'Donnell, Sara Ali, Patrícia R S Rodrigues, Angela Strang, Summia Zaher, Simran Sharma, Luke C Davies, Linda Moet, James E McLaren, Gareth L Watson, Peter Ghazal, Edward Parkinson, Sivakumar Oruganti, William John Watkins, Selyf Shapey, Rim al Samsam, Malcolm Gajraj, Michelle Jardine, Jong Eun Song, Lloyd Abood, Sarah Joanne Kotecha, Awen Evans, Iona Buchanan, Susan Bowes, Begum Ali, Maya Gore, Rhian Thomas-Turner, Federico Liberatore, Thomas Woolley
Publikováno v:
BMJ Open, Vol 13, Iss 3 (2023)
Introduction Early recognition and appropriate management of paediatric sepsis are known to improve outcomes. A previous system’s biology investigation of the systemic immune response in neonates to sepsis identified immune and metabolic markers th
Externí odkaz:
https://doaj.org/article/2d1c8f29b48f4539bf38b44ed3678f38
Autor:
Sarah N. Lauder, Victoria J Tyrrell, Keith Allen-Redpath, Maceler Aldrovandi, David Gray, Peter Collins, Simon A Jones, Philip R Taylor, Valerie O'Donnell
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
Background. The myeloid enzyme 12/15-lipoxygenase (LOX), which generates bioactive oxidized lipids, has been implicated in numerous inflammatory diseases, with several studies demonstrating an improvement in pathology in mice lacking the enzyme. Howe
Externí odkaz:
https://doaj.org/article/f5090539914842ae958ac2f738de381f
Autor:
Saranya Ravi, Balu Chacko, Hirotaka Sawada, Philip A Kramer, Michelle S Johnson, Gloria A Benavides, Valerie O'Donnell, Marisa B Marques, Victor M Darley-Usmar
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123597 (2015)
Platelet thrombus formation includes several integrated processes involving aggregation, secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which metabolic fuels are required to support these events. We hypoth
Externí odkaz:
https://doaj.org/article/ab466e185cc64b3b8f68f2bb25048a1e
Autor:
Borchert, Mariana Soria-Tiedemann, Geert Michel, Iris Urban, Maceler Aldrovandi, Valerie O’Donnell, Sabine Stehling, Hartmut Kuhn, Astrid
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9907
Glutathione peroxidase 4 (Gpx4) and arachidonic acid 15 lipoxygenase (Alox15) are counterplayers in oxidative lipid metabolism and both enzymes have been implicated in spermatogenesis. However, the roles of the two proteins in acrosomal exocytosis ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::247900aab8376588d5fb0920fc17745b
Autor:
Sivakumar Oruganti, Patrícia R S Rodrigues, Daniel White, William John Watkins, Selyf Shapey, Anna Barrow, Rim al Samsam, Sara Ali, Malcolm Gajraj, Richard Skone, Michelle Jardine, Jennifer Evans, Siske Struik, Jong Eun Song, Lloyd Abood, Barbara Paquete, Sian Foulkes, Benjamin Saunders, Angela Strang, Sarah Joanne Kotecha, Bethan Phillips, Awen Evans, Iona Buchanan, Susan Bowes, Begum Ali, Maya Gore, Rhian Thomas-Turner, Robert Andrews, Summia Zaher, Simran Sharma, Mallinath Chakraborty, Edward Parkinson, Federico Liberatore, Thomas Woolley, Sarah Edkins, Luke C Davies, Linda Moet, James E McLaren, Gareth L Watson, Valerie O'Donnell, Kerry Hood, Peter Ghazal
Publikováno v:
BMJ Open. 13:e067002
IntroductionEarly recognition and appropriate management of paediatric sepsis are known to improve outcomes. A previous system’s biology investigation of the systemic immune response in neonates to sepsis identified immune and metabolic markers tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07d1e14c9f4a76ad61d2a9b01f613420
https://doi.org/10.1136/bmjopen-2022-067002
https://doi.org/10.1136/bmjopen-2022-067002
Publikováno v:
Free Radical Biology and Medicine. 192:16-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06652c954d475753334847d90378a753
https://doi.org/10.1016/j.freeradbiomed.2022.10.009
https://doi.org/10.1016/j.freeradbiomed.2022.10.009
Publikováno v:
Poster presentations.
Background Communication between hospital and primary care at discharge is vital to ensure patients feel supported and prevent crisis readmissions. The hospital palliative care team (PCT) have developed comprehensive training for all doctors and prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a194da4d886bf522ed3669df886cc27
https://doi.org/10.1136/bmjspcare-2019-asp.148
https://doi.org/10.1136/bmjspcare-2019-asp.148
Publikováno v:
Palliative Medicine. 16:369-374
The management of ‘death rattle' was reviewed by a task group on behalf of the Association for Palliative Medicine's Science Committee. Evidence was searched for the effectiveness of various anti-muscarinic drugs in drying oropharyngeal and bronchi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703239dea62f6dafc9c28f0326dd8688
https://doi.org/10.1191/0269216302pm584oa
https://doi.org/10.1191/0269216302pm584oa
Autor:
Valerie O’Donnell
Publikováno v:
International Journal of Palliative Nursing. 4:199-203
Audible respiratory tract secretions in the dying patient are often referred to as the ‘death rattle’. This reflects the distressing nature of this symptom. The management of respiratory tract secretions in the dying patient is a challenge for al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::226862d07a90f7b8f812ce9e6f702bb5
https://doi.org/10.12968/ijpn.1998.4.4.9110
https://doi.org/10.12968/ijpn.1998.4.4.9110