Association studies of calcium-sensing receptor (CaSR) polymorphisms with serum concentrations of glucose and phosphate, and vascular calcification in renal transplant recipients.

Autor: Valerie N Babinsky, Fadil M Hannan, Sonia C Youhanna, Céline Maréchal, Michel Jadoul, Olivier Devuyst, Rajesh V Thakker

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119459 (2015)

Cardiovascular disease is the major cause of death in renal transplant recipients (RTRs) and linked to arterial calcification. The calcium-sensing receptor (CaSR), a G-protein coupled receptor, plays a pivotal role in extracellular calcium homeostasi

Externí odkaz: https://doaj.org/article/4a2f7aa74c8a4e81838c4a23fcf5adf3

15-LB: Prediction of Chronic Kidney Disease (CKD) in People with Diabetes

Autor: Valerie N. Babinsky, Helena König, Nader Afshar, Christian Ringemann, Tony Huschto, Magí Andorrà, John T. Odegard, Siva Chittajallu, Inderjit Singh, Heather Mikulski

Publikováno v: Diabetes. 70

Background: People with diabetes in general have a higher risk of developing Chronic Kidney Disease (CKD). The early detection of CKD in people with diabetes helps their health care providers to adjust their therapy to slow down the disease progressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbce537236b813886590d42d45441c9c
https://doi.org/10.2337/db21-15-lb

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling

Autor: Tomas Malinauskas, Caroline M Gorvin, Fadil M. Hannan, Rajesh V. Thakker, Valerie N. Babinsky, Aylin C. Hanyaloglu, E Y Jones, Christian Siebold, Anders J Schou, P H Nissen

Publikováno v: Gorvin, C M, Babinsky, V N, Malinauskas, T, Nissen, P H, Schou, A J, Hanyaloglu, A C, Siebold, C, Jones, E Y, Hannan, F M & Thakker, R V 2018, ' A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling ', Science Signaling, vol. 11, no. 518, eaan3714 . https://doi.org/10.1126/scisignal.aan3714
Science Signaling
SCIENCE SIGNALING

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through Gq/11 and Gi/o to stimulate cytosolic calcium (Ca2+ i) and mitogen-activated protein kinase (MAPK) signaling to control extracellular calcium homeostasis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f6115ff26a7d8f649a7954fa0014cd
https://doi.org/10.1126/scisignal.aan3714

The calcilytic SHP635 rectifies hypocalcaemia and reduced parathyroid hormone concentrations in a mouse model for autosomal dominant hypocalcaemia type 1 (ADH1)

Autor: Edward F Nemeth, Roger D. Cox, Michelle Stewart, Caroline M Gorvin, Rajesh Thakker, Sara Wells, Tertius Hough, Elizabeth Joynson, Valerie N. Babinsky, Fadil Hannan

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d475dacfb199ac4e0011402ff0e4eae
https://doi.org/10.1530/endoabs.44.p44

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders

Autor: Nigel Rust, Fadil M. Hannan, Rajesh V. Thakker, M. Andrew Nesbit, Caroline M Gorvin, Allen M. Spiegel, Valerie N. Babinsky, Sarah A. Howles, Jianxin Hu, Aylin C. Hanyaloglu

Publikováno v: Journal of Biological Chemistry
The Journal of Biological Chemistry

Germline loss- and gain-of-function mutations of G-protein α-11 (Gα11), which couples the calcium-sensing receptor (CaSR) to intracellular calcium (Ca(2+) i) signaling, lead to familial hypocalciuric hypercalcemia type 2 (FHH2) and autosomal domina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab95fe6248991a7835f10522f5d98ff8