Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Valerie M, Crowley"'
Autor:
Rosauro Varo, Valerie M. Crowley, Humberto Mucasse, Antonio Sitoe, Justina Bramugy, Lena Serghides, Andrea M. Weckman, Clara Erice, Rubao Bila, Pio Vitorino, Campos Mucasse, Marta Valente, Sara Ajanovic, Núria Balanza, Kathleen Zhong, Yiovanna Derpsch, Melissa Gladstone, Alfredo Mayor, Quique Bassat, Kevin C. Kain
Publikováno v:
International Journal of Infectious Diseases, Vol 139, Iss , Pp 34-40 (2024)
Objectives: We tested the hypothesis that adjunctive rosiglitazone treatment would reduce levels of circulating angiopoietin-2 (Angpt-2) and improve outcomes of Mozambican children with severe malaria. Methods: A randomized, double-blind, placebo-con
Externí odkaz:
https://doaj.org/article/35a487633f2b42adae155c4ba0365d55
Autor:
Andrea M. Weckman, Sarah Anne J. Guagliardo, Valerie M. Crowley, Lucia Moro, Chiara Piubelli, Tamara Ursini, Sabrina H. van Ierssel, Federico G. Gobbi, Hannah Emetulu, Aisha Rizwan, Kristina M. Angelo, Carmelo Licitra, Bradley A. Connor, Sapha Barkati, Michelle Ngai, Kathleen Zhong, Ralph Huits, Davidson H. Hamer, Michael Libman, Kevin C. Kain
Publikováno v:
Viruses, Vol 16, Iss 10, p 1615 (2024)
Background: The effect of the COVID-19 pandemic on healthcare systems emphasized the need for rapid and effective triage tools to identify patients at risk of severe or fatal infection. Measuring host response markers of inflammation and endothelial
Externí odkaz:
https://doaj.org/article/0bb3001d7a2e4d79be9b20871917733c
Autor:
Timothy James Russell, Erandi K De Silva, Valerie M Crowley, Kathryn Shaw-Saliba, Namita Dube, Gabrielle Josling, Charisse Flerida A Pasaje, Irene Kouskoumvekaki, Gianni Panagiotou, Jacquin C Niles, Marcelo Jacobs-Lorena, C Denise Okafor, Francisco-Javier Gamo, Manuel Llinás
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010887 (2022)
Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial dru
Externí odkaz:
https://doaj.org/article/32dbbe0804b44aea83886f60da9addc8
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Severe malaria (SM) is a leading cause of global morbidity and mortality, particularly in children in sub-Saharan Africa. However, existing malaria diagnostic tests do not reliably identify children at risk of severe and fatal outcomes. Dysregulated
Externí odkaz:
https://doaj.org/article/3d35ea9ac6e342118e8a384053331f4b
Autor:
Vanessa Tran, Andrea M. Weckman, Valerie M. Crowley, Lindsay S. Cahill, Kathleen Zhong, Ana Cabrera, Robyn E. Elphinstone, Victoria Pearce, Mwayiwawo Madanitsa, Linda Kalilani-Phiri, Victor Mwapasa, Carole Khairallah, Andrea L. Conroy, Feiko O. ter Kuile, John G. Sled, Kevin C. Kain
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103683- (2021)
Background: Malaria during pregnancy is a major contributor to the global burden of adverse birth outcomes including fetal growth restriction, preterm birth, and fetal loss. Recent evidence supports a role for angiogenic dysregulation and perturbatio
Externí odkaz:
https://doaj.org/article/70589bcf3d034d399a3578776efe1f17
Autor:
Oleg Dmytrenko, Gina C. Neumann, Thomson Hallmark, Dylan J. Keiser, Valerie M. Crowley, Elena Vialetto, Ioannis Mougiakos, Katharina G. Wandera, Hannah Domgaard, Johannes Weber, Thomas Gaudin, Josie Metcalf, Benjamin N. Gray, Matthew B. Begemann, Ryan N. Jackson, Chase L. Beisel
Publikováno v:
Nature. 613:588-594
Bacterial abortive-infection systems limit the spread of foreign invaders by shutting down or killing infected cells before the invaders can replicate1,2. Several RNA-targeting CRISPR–Cas systems (that is, types III and VI) cause abortive-infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44265aa9ba3371232e3ac72b3f09f891
https://doi.org/10.1038/s41586-022-05559-3
https://doi.org/10.1038/s41586-022-05559-3
Autor:
Rosauro Varo, Valerie M. Crowley, Antonio Sitoe, Lola Madrid, Lena Serghides, Kevin C. Kain, Quique Bassat
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-18 (2018)
Abstract Background Despite recent efforts and successes in reducing the malaria burden globally, this infection still accounts for an estimated 212 million clinical cases, 2 million severe malaria cases, and approximately 429,000 deaths annually. Ev
Externí odkaz:
https://doaj.org/article/43b697e14bef4c9d9cbaadc636043e40
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-11 (2017)
Abstract Background Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection associated with high mortality and neurocognitive impairment in survivors. New anti-malarials and host-based adjunctive therapy may improve clinical
Externí odkaz:
https://doaj.org/article/5a7c636fffe2429daa2ac79ec7d835b9
Autor:
Rosauro Varo, Valerie M. Crowley, Antonio Sitoe, Lola Madrid, Lena Serghides, Rubao Bila, Helio Mucavele, Alfredo Mayor, Quique Bassat, Kevin C. Kain
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-8 (2017)
Abstract Background Despite the widespread use and availability of rapidly acting anti-malarials, the fatality rate of severe malaria in sub-Saharan Africa remains high. Adjunctive therapies that target the host response to malaria infection may furt
Externí odkaz:
https://doaj.org/article/22664b9c57514e5b95e305f37e421e02
Autor:
Jimmy Poulin, Nicholas J. Provart, Valerie M. Crowley, Daniel C. Johnson, Dea Shahinas, Michael Kanaris, Geoffrey Fucile, Dinesh Christendat
Publikováno v:
The Plant Journal. 109:789-803
The shikimate pathway plays a central role in the biosynthesis of aromatic amino acids and specialized metabolites in plants. The first enzyme, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAHPS) serves as a key regulatory point for the path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f716d8fd9d9357c21d23a02fdf4642cd
https://doi.org/10.1111/tpj.15590
https://doi.org/10.1111/tpj.15590